Effect of Combination Lipid-Modifying Therapy on the Triglyceride Lowering Effect of Fish Oil

Aligeti, Venkata R.; Gandhi, Malay; Elam, Marshall B.; Braden, Ron; Rezk, A.

doi:10.1097/maj.0b013e3180312ebf

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…In addition to their effects on plasma triglycerides, studies have investigated the impact of fish oils on other lipid parameters including LDL-cholesterol and HDL-cholesterol. In this category, variable effects have been observed; some have reported modest increases in LDL (Harris 1997) while others have reported no significant changes in either LDL or HDL in response to fish oil administration (Aligeti et al, 2007). The inconsistency in the literature may be related to the dose of fish oils used as well as the ApoE genotype (discussed above).…”

Section: Effect Of Fish Oils On Lipoproteinsmentioning

confidence: 99%

Fish Oil and the Management of Hypertriglyceridemia

Mattar

Obeid

2009

Nutr Health

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Hypertriglyceridemia, regarded as one of the independent clinical markers of metabolic syndrome, is a frequently observed disorder that has been shown to be common in the Arab region. Epidemiologic and clinical trials demonstrated that omega-3 fatty acids have the potential to reduce the incidence of cardiovascular disease (CVD); one of the mechanisms by which this effect is achieved is through reducing plasma triglyceride levels. There is strong scientific evidence from human trials that omega-3 fatty acids from either fish or fish oil supplements significantly reduce blood triglyceride levels and these benefits appear to be dose-dependent. The active ingredients of fish oils include the long chain fatty acids EPA and DHA. The ideal amount of omega-3 fatty acid that should be incorporated into the diet without provoking detrimental effects on other lipid components such as decreasing HDL-C and/or increasing LDL-C has not yet been elucidated. Presently, a prescription form of omega-3 fatty acid has been approved by the United States Food and Drug Administration (USFDA) as an adjunct to the diet for the treatment of very high triglyceride levels (> or = 500 mg/dl) in adults. Patients with hypertriglyceridemia have been shown to respond well to the use of omega-3 fatty acids even when used in conjunction with statins where greater improvements in the lipid profile were found as compared to treatment with statins alone. A determinant of the responsiveness to fish oil could be attributed to the ApoE genotype of individuals.

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Section: Effect Of Fish Oils On Lipoproteinsmentioning

confidence: 99%

Fish Oil and the Management of Hypertriglyceridemia

Mattar

Obeid

2009

Nutr Health

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“…drugs, including statins (106) . They found that adding fish oil to a statin alone or to multiple lipid-lowering drugs (combination of niacin, statin and/or fibrates) did not alter the TAG-lowering effects of fish oil and effects are therefore additive.…”

Section: Effects Of Combination Therapy With N-3 Pufa and Statinsmentioning

confidence: 99%

Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

et al. 2010

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Functional foods and dietary supplements might have a role in supporting drug therapy. These products may (1) have an additive effect to the effect that a drug has in reducing risk factors associated with certain conditions, (2) contribute to improve risk factors associated with the condition, other than the risk factor that the drug is dealing with, or (3) reduce drug-associated side effects, for example, by restoring depleted compounds or by reducing the necessary dose of the drug. Possible advantages compared with a multidrug therapy are lower drug costs, fewer side effects and increased adherence. In the present review we have focused on the support of statin therapy using functional foods or dietary supplements containing plant sterols and/or stanols, soluble dietary fibre, n-3 PUFA or coenzyme Q 10 . We conclude that there is substantial evidence that adding plant sterols and/or stanols to statin therapy further reduces total and LDL-cholesterol by roughly 6 and 10 %, respectively. Adding n-3 PUFA to statin therapy leads to a significant reduction in plasma TAG of at least 15 %. Data are insufficient and not conclusive to recommend the use of soluble fibre or coenzyme Q 10 in patients on statin therapy and more randomised controlled trials towards these combinations are warranted. Aside from the possible beneficial effects from functional foods or dietary supplements on drug therapy, it is important to examine possible (negative) effects from the combination in the long term, for example, in post-marketing surveillance studies. Moreover, it is important to monitor whether the functional foods and dietary supplements are taken in the recommended amounts to induce significant effects. Combination therapy: Dyslipidaemia: Statins: Functional foodsThe world market for functional foods (FF) and dietary supplements (DS) is expanding rapidly. In 2010 FF are expected to represent 5 % of the total global food market (1) and the market for DS is estimated at more than $60 billion worldwide (2) . In general, the target population of FF or DS is healthy individuals with slightly elevated risk factors or some physical discomfort. However, due to the fast growing market of FF or DS and the accompanying strong advertising and marketing, also patients on medication may be stimulated to use FF or DS. This may have several consequences for the quality of drug treatment as stated by de Jong et al. with the example of the combined intake of plant sterols and/or stanols and statins (3) . Whereas they addressed the additive effect of plant sterols and/or stanols on reducing LDL-cholesterol values in patients on statin treatment, their main focus was the possible negative aspects of the combination, such as unfavourable effects on patient adherence with drug treatment and increasing the potential for food-drug interactions.In the present review we will focus on the possible beneficial effects that FF or DS may have on drug therapy. Because of the large number of subjects treated suboptimally with statins (hydroxymethylglutaryl Co...

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“…The American Food and Drug Administration has approved -3 FAs for the treatment of SHTG [15] . Furthermore it is known that fish oil capsules can safely be combined with other medications in the treatment of SHTG [16] .…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Severe Hypertriglyceridemia with a Formula Diet Rich in Omega–3 Fatty Acids and Medium-Chain Triglycerides

Hauenschild

Bretzel²,

Schnell-Kretschmer³

et al. 2010

Ann Nutr Metab

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Background: Patients with highly increased plasma triglyceride levels are at risk of developing serious complications such as pancreatitis, coronary heart disease and stroke. Therefore it is important to rapidly decrease plasma triglyceride levels. A sufficient control of triglyceride levels with drugs like fibrates, statins or nicotinic acid can usually only be attained after a couple of weeks. Plasma exchange appears to be a fast but expensive method to reduce triglyceride levels. In this study we describe the use of a new ω–3 fatty acid and medium-chain triglyceride-rich formula diet as a therapeutic concept to reduce plasma triglyceride levels fast and effectively. Methods: Thirty-two patients with severe hypertriglyceridemia were treated with the especially composed formula diet for a period of 7 days. Results: Within this period of time, plasma triglycerides decreased from 1,601 (402–4,555) to 554 (142–2,382) mg/dl (p < 0.05). Total cholesterol levels were reduced from 417 (211–841) to 287 (165–457) mg/dl (p < 0.001). Fasting glucose and uric acid levels also slightly decreased (–8%; –12%). The formula diet as a 1-week treatment was well tolerated and accepted by the patients. Conclusion: This diet was successfully used as an acute treatment in severe hypertriglyceridemia and showed effectiveness in rapidly and safely lowering plasma triglyceride levels.

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Effect of Combination Lipid-Modifying Therapy on the Triglyceride Lowering Effect of Fish Oil

Cited by 5 publications

References 15 publications

Fish Oil and the Management of Hypertriglyceridemia

Fish Oil and the Management of Hypertriglyceridemia

Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

Successful Treatment of Severe Hypertriglyceridemia with a Formula Diet Rich in Omega–3 Fatty Acids and Medium-Chain Triglycerides

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