Effect of Combination of Preoperative Ibuprofen/Acetaminophen on the Success of the Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis

Simpson, Michael G.; Drum, Melissa; Nusstein, John; Reader, Al; Beck, Mike

doi:10.1016/j.joen.2011.02.015

Cited by 73 publications

(81 citation statements)

References 32 publications

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“…Acetaminophen inhibits prostaglandin synthesis, and interacts with both cannabinoid and serotoninergic pathways. So, acetaminophen has been considered to have some additional analgesic effect when used in combination with ibuprofen.Acetaminophen has been considered to have some additional analgesic effect on ibuprofen so this might increase the success rate of ibuprofen when used in combination with ibuprofen 10 . However, nonsteroidal anti-inflammatory drugs suffer from major pharmacodynamic limitations i.e.…”

Section: Introductionmentioning

confidence: 99%

A comparative clinical study to evaluate the effectof premedication with Ibuprofen, Tramadol and combination of Ibuprofen and Acetaminophen on success of Inferior Alveolar Nerve Block in patients with Asymptomatic Irreversible Pulpitis.

Mahajan

Singh

Kaur

et al. 2017

Bangladesh J Med Sci

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Introduction: Aim of this study was to evaluate the effective of premedication and to determine the difference between non steroidal anti-inflammatory drugs and centrally acting opioids like tramadol on success rate of inferior alveolar nerve block in patients with asymptomatic irreversible pulpitis. Methods: This double blind clinical study was conducted on 60 patients with asymptomatic irreversible pulpitis in first or second mandibular molar with normal periapical radiographic findings. Three medications i.e., ibuprofen (600mg), tramadol (50 mg) and combination of ibuprofen (400 mg) + acetaminophen (325) were compared and lactose powder capsules were taken as placebo. All patients received IANB and teeth were examined with a cold pulp test using endofrost. Then, endodontic access cavity preparation was initiated. In case of pain during treatment, patients were asked to rate their pain on the visual analog scale. Results: The tramadol group showed significantly higher success rates but ibuprofen and combination of ibuprofen and acetaminophen groups were not significant with placebo (p>05). No Significant differences were there regarding sex of the patients. Conclusion: Premedication with tramadol increased the success rate of IANB.

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Section: Introductionmentioning

confidence: 99%

A comparative clinical study to evaluate the effectof premedication with Ibuprofen, Tramadol and combination of Ibuprofen and Acetaminophen on success of Inferior Alveolar Nerve Block in patients with Asymptomatic Irreversible Pulpitis.

Mahajan

Singh

Kaur

et al. 2017

Bangladesh J Med Sci

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“…It is in agreement with other studies. 1,14 During the statistical analysis, there was a significant reduction in pain incidence in patients received prophylactic intra-oral infiltration dexamethasone infiltration and oral Ibuprufen versus the only oral administration of nonsteroidal antiinflammatory drug (ibuprufen).…”

Section: Discussionmentioning

confidence: 99%

“…In the field of endodontics, the pain is relieved by chemo-mechanical preparation for the effective cleaning of causative organisms and obturation of the root canals that prevents and discourages the re-entry of infected flora into the root canal system. 1,2 In cases of irreversible pulpitis or pulp necrosis, the treatment of choice is root canal treatment. Irreversible pulpitis is characterized by the presence of severe pain that can be throbbing or stabbing.…”

Section: Introductionmentioning

confidence: 99%

Frequency of post obturation pain by using ibuprofen and ibuprofen/dexamethasone infiltration in single visit root canal treatment cases

Rana

Rana²,

Akhtar³

et al. 2018

Int J Clin Trials

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Background: Pain after root canal treatment is a challenging problem for the operative dentists over the last few years. The development of pain is dependent on the intensity of tissue damage. Inflammation is characterized by a series of vascular events in response to tissue injury. The release of mediators is responsible for much of the pain. The rationale of this study is to use NSAIDs alone or in combination with dexamethasone to reduce post treatment swelling and pain following endodontic therapy. The objective of the study was to compare the frequency of post obturation pain by using ibuprofen or ibuprofen/ dexamethasone infiltration in single visit endodontic cases.Methods: This study was carried out in the Operative Dentistry, Department (AFID), Rawalpindi, Pakistan from December 2015 to May 2016 after approval from the Institutional Ethical Review Board. After an informed consent, 128 patients fulfilling inclusion criteria were divided in to two equal groups. In Group A, after root canal treatment, an additional single shot local infiltration of 0.5 mg dexamethasone was given in periapical area. Both the patient groups were prescribed ibuprofen 400 mg three times a day. Patient’s pain response was recorded after 24 hours of treatment, using visual analogue scale. Data was analyzed using SPSS version 17.Results: After 24 hours, 6 (9.4%) patients showed the pain in group A while 16 (25.0%) patients complained of pain in group B. Conclusions: The results of this study showed, group A showed less postoperative pain as compared to group B where only ibuprofen was given.

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“…Oleson et al (2010) and Aggarwal et al (2009) failed to show a significant difference in the success rate of IANB when the anesthesia was accompanied by premedication with two different doses of ibuprofen (600 and 800 mg). Likewise, Simpson et al (2011) concluded that premedication with 800 mg ibuprofen +1000 mg acetaminophen has no significant effect in the success of IANB in patients with symptomatic irreversible pulpitis. Oleson et al (2010) further stated that while Ibuprofen can inhibit the production of new prostaglandins, early production of other inflammatory mediators and the effects of pre-activated nociceptors are likely responsible for the high failure rate of anesthesia even after taking the analgesic agent.…”

Section: Discussionmentioning

confidence: 99%

“…Several other researchers including Aggarwal et al (2009), Oleson et al (2010 and Simpson et al (2011) reported an insignificant improvement in the success of IANB accompanied by premedication with analgesics in treating irreversible pulpitis. Numerous analgesics are used for pain control in endodontics.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of premedication with ibuprofen, gelofen and acetaminophen in the depth of anesthesia in mandibular molars with irreversible pulpitis

Madani¹

2013

Afr. J. Pharm. Pharmacol.

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Pain control is one of the major aspects in dental practice. Dental pain can usually be controlled using different techniques such as local anesthesia and medications. Acetaminophen is a pain reliever and fever reducer. However, it shows no effect on inflammation. Therefore, non-steroidal anti-inflammatory drugs are currently used to control inflammation and pain. This study sought to compare the efficacy of premedication with ibuprofen, gelofen and acetaminophen in the depth of anesthesia in mandibular molars with irreversible pulpitis. In this double-blind randomized controlled trial, 60 patients with at least one mandibular molar with symptoms of irreversible pulpitis requiring root canal therapy were recruited. Another tooth in the same quadrant was selected as the control. Patients were randomly allocated to one of the following groups: ibuprofen 400 mg, gelophen 400 mg, acetaminophen 325 mg, and placebo 500 mg. The medications were taken 30 min prior to local anesthesia and the cold test and electric pulp test (EPT) were repeated for the test teeth and the control teeth after 10 min with the development symptoms of anesthesia. Access preparation was then initiated and the patients were asked to quantify the level of pain during exposure of the dentin and pulp using a visual analogue scale (VAS). Data was analyzed using analysis of variance (ANOVA), and repeated measure ANOVA, P < 0.05 were deemed significant. There were significant differences between the mean baseline VAS score, and the mean VAS score recorded at the time of dentin and pulp exposure however revealed a significant difference in the VAS score only at the time of dentin exposure among the study groups (P < 0.005). No significant difference was observed in the mean VAS score at the time of pulp exposure among groups (P = 0.076). The EPT was significantly higher after the test compared with the baseline (P = 0.421). Premedication with ibuprofen and gelofen have significant effect in the depth of anesthesia in mandibular molars with irreversible pulpitis, and significantly decreased VAS but placebo and acetaminophen are functionally alike and had no significant effect.

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Effect of Combination of Preoperative Ibuprofen/Acetaminophen on the Success of the Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis

Cited by 73 publications

References 32 publications

A comparative clinical study to evaluate the effectof premedication with Ibuprofen, Tramadol and combination of Ibuprofen and Acetaminophen on success of Inferior Alveolar Nerve Block in patients with Asymptomatic Irreversible Pulpitis.

A comparative clinical study to evaluate the effectof premedication with Ibuprofen, Tramadol and combination of Ibuprofen and Acetaminophen on success of Inferior Alveolar Nerve Block in patients with Asymptomatic Irreversible Pulpitis.

Frequency of post obturation pain by using ibuprofen and ibuprofen/dexamethasone infiltration in single visit root canal treatment cases

The efficacy of premedication with ibuprofen, gelofen and acetaminophen in the depth of anesthesia in mandibular molars with irreversible pulpitis

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