Effect of Combination Pretreatment of Polyethylene Glycol Solution and Magnesium Hydroxide for Colonoscopy

Shin, Eun Jung; Park, Seun Ja; Kim, Kyu Jong; Moon, Won; Park, Moo In; Lim, Dong Han; Park, Eun Ho; Lee, Jee Suk

doi:10.4166/kjg.2010.55.4.232

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…Studies have shown that some drugs, such as magnesium hydroxide 24 and bisacodyl, could be helpful for bowel preparation in patients with constipation, especially those with slow CTT. 25 26 Therefore, we suggest that these medications could be helpful for bowel preparation in patients with slow CTT.…”

Section: Discussionmentioning

confidence: 99%

Colon Transit Time May Predict Inadequate Bowel Preparation in Patients With Chronic Constipation

et al. 2015

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Background/AimsWe evaluated whether colonic transit time (CTT) can predict the degree of bowel preparation in patients with chronic constipation undergoing scheduled colonoscopy in order to assist in the development of better bowel preparation strategies for these patients.MethodsWe analyzed the records of 160 patients with chronic constipation from March 2007 to November 2012. We enrolled patients who had undergone a CTT test followed by colonoscopy. We defined patients with a CTT ≥30 hours as the slow transit time (STT) group, and patients with a CTT <30 hours as the normal transit time (NTT) group. Boston Bowel Preparation Scale (BBPS) scores were compared between the STT and NTT groups.ResultsOf 160 patients with chronic constipation, 82 (51%) were included in the STT group and 78 (49%) were included in the NTT group. Patients with a BBPS score of <6 were more prevalent in the STT group than in the NTT group (31.7% vs. 10.3%, P=0.001). Multivariate analysis showed that slow CTT was an independent predictor of inadequate bowel preparation (odds ratio, 0.261; 95% confidence interval, 0.107-0.634; P=0.003). The best CTT cut-off value for predicting inadequate bowel preparation in patients with chronic constipation was 37 hours, as determined by receiver operator characteristic (ROC) curve analysis (area under the ROC curve: 0.676, specificity: 0.735, sensitivity: 0.643).ConclusionsPatients with chronic constipation and a CTT >30 hours were at risk for inadequate bowel preparation. CTT measured prior to colonoscopy could be useful for developing individualized strategies for bowel preparation in patients with slow CTT, as these patients are likely to have inadequate bowel preparation.

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Section: Discussionmentioning

confidence: 99%

Colon Transit Time May Predict Inadequate Bowel Preparation in Patients With Chronic Constipation

et al. 2015

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“…103 Polyethylene glycol (PEG) solution plus magnesium hydroxide induced more significantly effective colonic preparation in constipated patients, compared with PEG solution alone. 104 In conclusion, few studies have examined the effect of magnesium hydroxide, but many clinicians believe that it improves stool frequency and consistency in patients with normal renal function.…”

Section: Statement: Magnesium Salts Improve Stool Frequency and Consimentioning

confidence: 99%

Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition

Shin

Jung

Lee

et al. 2016

J Neurogastroenterol Motil

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The Korean Society of Neurogastroenterology and Motility first published guidelines for chronic constipation in 2005 and was updated in 2011. Although the guidelines were updated using evidence-based process, they lacked multidisciplinary participation and did not include a diagnostic approach for chronic constipation. This article includes guidelines for diagnosis and treatment of chronic constipation to realistically fit the situation in Korea and to be applicable to clinical practice. The guideline development was based upon the adaptation method because research evidence was limited in Korea, and an organized multidisciplinary group carried out systematical literature review and series of evidence-based evaluations. Six guidelines were selected using the Appraisal of Guidelines for Research & Evaluation (AGREE) II process. A total 37 recommendations were adopted, including 4 concerning the definition and risk factors of chronic constipation, 8 regarding diagnoses, and 25 regarding treatments. The guidelines are intended to help primary physicians and general health professionals in clinical practice in Korea, to provide the principles of medical treatment to medical students, residents, and other healthcare professionals, and to help patients for choosing medical services based on the information. These guidelines will be updated and revised periodically to reflect new diagnostic and therapeutic methods.

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“…Combining magnesium hydroxide with another laxative may improve these side effects by reducing the dose of both laxatives. Shin et al (2010) found that the combined administration of magnesium hydroxide and PEG increased bowel clearance compared with PEG treatment alone during colonoscopy in patients with constipation. Similarly, the combination of magnesium hydroxide and lactulose significantly improved stool parameters and increased total SCFA production, including acetic acid, compared with lactulose alone ( Fig.…”

Section: Discussionmentioning

confidence: 96%

Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice

Park,

Lee,

Hong

et al. 2023

Prev. Nutr. Food Sci.

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We evaluated the efficacy of mixtures of lactulose with probiotic strains to ameliorate constipation and to identify suitable probiotic strains. Constipation was induced in Institute of Cancer Research mice (6-week-old, male) by the administering loperamide (5 mg/kg, twice a day) orally for 5 days, whereas the control group was not treated. To evaluate the laxative effects of the lactulose-probiotic and lactulose-magnesium hydroxide mixtures, fecal parameters, the gastrointestinal (GI) transit ratio, and fecal short-chain fatty acid (SCFA) content were analyzed. The administration of lactulose and Bacillus licheniformis or Saccharomyces boulardii significantly improved stool number and water content, which were reduced by loperamide. The GI transit ratio was significantly increased compared with that of the control group. The combined administration of lactulose and probiotics ( B. licheniformis or S. boulardii ) increased total SCFA content, including that of acetate, more effectively compared with lactulose alone. Similarly, coadministration of lactulose and magnesium hydroxide improved the loperamide-induced changes in fecal parameters and GI transit as well as increased total SCFA content. Overall, the combination of lactulose and probiotics relieves the symptoms of constipation by increasing SCFA content and is more effective compared with lactulose alone.

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Effect of Combination Pretreatment of Polyethylene Glycol Solution and Magnesium Hydroxide for Colonoscopy

Abstract: Bowel preparation with magnesium hydroxide and 4 liters of PEG solution might reduce solid stool in constipation group, but could not improve preparation quality.

Cited by 7 publications

References 18 publications

Colon Transit Time May Predict Inadequate Bowel Preparation in Patients With Chronic Constipation

Colon Transit Time May Predict Inadequate Bowel Preparation in Patients With Chronic Constipation

Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition

Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice

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