Effect of combination therapy of radiation and local administration of OK-432 on a murine fibrosarcoma

Mukai, Minoru; Andō, Kōichi; Koike, Sachiko; Nagao, Kōichi

doi:10.1016/0360-3016(89)90379-9

Cited by 9 publications

(2 citation statements)

References 6 publications

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“…Combination therapies of an intratumoral injection of OK-432 and local treatment with irradiation or hyperthermia were reported to be effective [18,[28][29][30][31]. In these cases, OK-432 was most effective when it was injected just after or before treatment with local irradiation or local hyperthermia.…”

Section: Discussionmentioning

confidence: 94%

Effect of combination treatment of 15 cGy total body irradiation and OK-432 on spontaneous lung metastasis and mitogenic response of splenocytes in mice

Hosoi

Ishii

Yamada

et al. 1997

Radiat. Oncol. Investig.

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We investigated whether the combination treatment of 15 cGy total body irradiation (TBI) and a streptococcal preparation, OK‐432, synergistically suppresses spontaneous lung metastasis and augments phytohemagglutinin (PHA) and concanavalin A (Con A) responses of splenocytes in WHT/Ht mice. TBI with 15 cGy was carried out 20 days after subcutaneous injection of squamous cell carcinoma cells into a hind leg. Lung colony number was counted 40 days after tumor injection. For PHA and Con A responses, mice were killed 4 hr after 15 cGy TBI. The combination treatment of 15 cGy TBI and OK‐432 was most effective when OK‐432 was administered 2 days before 15 cGy TBI. The combination treatment decreased the lung colony number to 29.9% of the control number. OK‐432 slightly increased the PHA and Con A responses, and 15 cGy TBI did not increase them. However, when these two were combined, the PHA and Con A responses were significantly increased to 393% and 278% of the control levels, respectively. It was suggested that TBI and OK‐432 acted synergistically in suppressing the lung metastasis and mitogenic response of splenocytes. Radiat. Oncol. Invest. 5:283–288, 1997. © 1997 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 94%

Effect of combination treatment of 15 cGy total body irradiation and OK-432 on spontaneous lung metastasis and mitogenic response of splenocytes in mice

Hosoi

Ishii

Yamada

et al. 1997

Radiat. Oncol. Investig.

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“…1 We have been using a combination therapy of radiation and local administration of OK-432 in patients with esophageal cancer since 1987. Recently, we reported the results of a combination therapy study 2 that showed local esophageal cancer control and 5-year survival rates that were almost 2 times higher than the reported data.…”

Section: Introductionmentioning

confidence: 99%

Multidisciplinary treatment with OK-432 for tracheal or bronchial invasion by post-surgical esophageal cancer recurrences

Mukai¹,

Morita²,

Tsujii³

1996

Int J Clin Oncol

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Three patients with recurrent tumors invading the trachea or main bronchus after esophageal cancer surgery, underwent a multidisciplinary treatment using radiation and local administration of OK-432 with or without chemotherapy. Three patients were irradiated at a daily dose of 1.8 Gy, 5 fractions per week. The total dose of radiation ranged from 52.2 to 64.8 Gy. A dose of 1 mg or 0.5 mg of OK-432, dissolved in 3 mL of 0.5% xylocaine was administered submucosal[y at proximal sites of the tumor via a bronchofiberscope. Two of the patients also received a second injection of OK-432 2 weeks after the first dose. A complete response was obtained in 2 of the patients and a partial response occurred in the remaining patient. The patients with a complete response have been in good condition without any sign of recurrence for more than 2 and 6 years, respectively. Dyspnea was effectively cured in all 3 patients.

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Roles of langerhans' cells and T-lymphocytes infiltrating cancer tissues in patients treated by radiation therapy for cervical cancer

Nakano¹,

Oka²,

Takahashi³

et al. 1992

Cancer

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Correlations between infiltration of immunologic cells in tumor tissues and prognosis of radiation therapy were investigated for 275 patients with cervical cancer who were treated with radiation therapy alone, including 216 patients with Stage 111 squamous cell carcinomas and 59 with adenocarcinomas of all stages. Langerhans' cell (LC) and T‐cell were stained immunohistochemically on the specimens excised from the cervical cancer. In squamous cell carcinoma, 5‐year survival rates for patients with LC infiltration were significantly better than those without LC (78% versus 60%; P < 0.01). The 5‐year survival rate of patients with T‐cell infiltration also was significantly better than that of patients without such infiltration (83% versus 61%; P < 0.05). Similar trends were observed in patients with adenocarcinoma; 5‐year survival rates for patients with LC infiltration and those without LC infiltration were 49% and 25%, respectively (P < 0.025). The survival rates for patients with T‐cell infiltration and those without were 50% and 33%, respectively (P < 0.1). An analysis of patterns of failure of radiation therapy demonstrated that the favorable prognosis in LC infiltration was attributable mainly to improvement of local control rates, but that in T‐cell infiltration was not. T‐cells infiltrated into tumor specifically in the patients with LC infiltration in both cell types. The authors suggest that the host anti‐cancer immune response of individual patients may be remarkably different at the first step of antigen recognition by LC. The LC may induce T‐cell‐mediated antitumor response and improve local response in radiation therapy.

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Effect of combination therapy of radiation and local administration of OK-432 on a murine fibrosarcoma

Cited by 9 publications

References 6 publications

Effect of combination treatment of 15 cGy total body irradiation and OK-432 on spontaneous lung metastasis and mitogenic response of splenocytes in mice

Effect of combination treatment of 15 cGy total body irradiation and OK-432 on spontaneous lung metastasis and mitogenic response of splenocytes in mice

Multidisciplinary treatment with OK-432 for tracheal or bronchial invasion by post-surgical esophageal cancer recurrences

Roles of langerhans' cells and T-lymphocytes infiltrating cancer tissues in patients treated by radiation therapy for cervical cancer

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