Effect of combined adoptive immunotherapy and radiotherapy on tumor growth

Sumareva, R.; Ukrainsky, G.; Kiremidjian-Schumacher, L.; Roy, Marie‐Josée; Wishe, H. I.; Steinfeld, Aldo; Cooper, Jay S.

doi:10.1002/(sici)1520-6823(1999)7:1<22::aid-roi3>3.0.co;2-6

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…The combination of MV-infected CIK cells with XRT significantly prolonged the survival of mice with subcutaneous or disseminated human myeloma compared to CIK/MV. Recent studies using irradiation and adoptive immunotherapy showed that irradiation of malignant tumor cells enhanced killer cell-mediated cytotoxicity [64, 65]. The NKG2D ligands MICA and MICB are known to be induced by ionizing radiation [66] which may enhance trafficking of the CIK cells to tumors and/or killing by CIK cells.…”

Section: Discussionmentioning

confidence: 99%

Enhancing cytokine-induced killer cell therapy of multiple myeloma

Liu

Suksanpaisan

Chen

et al. 2013

Experimental Hematology

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Cytokine induced killer (CIK) cells are in clinical testing against various tumor types including multiple myeloma. Here, we show that CIK cells have activity against subcutaneous and disseminated models of human myeloma (KAS-6/1) which can be enhanced by infecting the CIK cells with an oncolytic measles virus (MV) or by pre-treating the myeloma cells with ionizing radiation (XRT). KAS-6/1 cells were killed by co-culture with CIK or MV-infected CIK (CIK/MV) cells and addition of an anti-NKG2D antibody inhibited cytolysis by 50%. Human bone marrow stromal cells can however reduce CIK and CIK/MV mediated killing of myeloma cells (RPMI 8226, JJN-3 and MM1). In vivo, CIK and CIK/MV prolonged the survival of mice with systemic myeloma, although CIK/MV showed enhanced antitumor activity compared to CIK. Irradiation of the KAS-6/1 cells induced mRNA and protein expression of NKG2D ligands, MICA and MICB, in a dose dependent manner and enhanced delivery of CIK/MV to the irradiated tumors. In both subcutaneous and disseminated myeloma models, XRT at 2 Gy resulted in superior prolongation of the survival of mice given CIK/MV therapy compared to CIK/MV with no XRT. This study demonstrates the potential of CIK against myeloma and that combination of virotherapy with radiation could be used to further enhance therapeutic outcome using CIK cells.

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Section: Discussionmentioning

confidence: 99%

Enhancing cytokine-induced killer cell therapy of multiple myeloma

Liu

Suksanpaisan

Chen

et al. 2013

Experimental Hematology

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“…The orthotopic model can provide an experimental environment more similar to the original tumor environment than the ectopic model (28). Besides, more aggressive behaviors of regional and distant metastasis were discovered in the orthotopic models (114,115). However, the growth of intra-oral tumors in the orthotopic model will not only cause pain but also hinder the diet of mice, which is against humanitarianism.…”

Section: Characteristics Of Xenograft Oscc Mouse Modelsmentioning

confidence: 99%

Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma

Dong

Yang

et al. 2020

Front. Oncol.

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Preclinical animal models of oral squamous cell carcinoma (OSCC) have been extensively studied in recent years. Investigating the pathogenesis and potential therapeutic strategies of OSCC is required to further progress in this field, and a suitable research animal model that reflects the intricacies of cancer biology is crucial. Of the animal models established for the study of cancers, mouse tumor-bearing models are among the most popular and widely deployed for their high fertility, low cost, and molecular and physiological similarity to humans, as well as the ease of rearing experimental mice. Currently, the different methods of establishing OSCC mouse models can be divided into three categories: chemical carcinogen-induced, transplanted and genetically engineered mouse models. Each of these methods has unique advantages and limitations, and the appropriate application of these techniques in OSCC research deserves our attention. Therefore, this review comprehensively investigates and summarizes the tumorigenesis mechanisms, characteristics, establishment methods, and current applications of OSCC mouse models in published papers. The objective of this review is to provide foundations and considerations for choosing suitable model establishment methods to study the relevant pathogenesis, early diagnosis, and clinical treatment of OSCC.

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“…124 Sumareva et al employed the subcutaneous injection of DBA/2 mice with KLN 205 cells, a HNSCC cell line of DBA/2 mouse origin, to illustrate the effectiveness of sustained peritumoral treatment with IL-2 combined with radiation therapy. 125 Thomas et al used 4-NQO to transform oral keratinocytes derived from BALB/c mice to produce tumorigenic cell lines that have been subcutaneously injected into immunocompetent BALB/c mice. 121,122 The model consists of 5 clonal cell lines and 5 matched progeny cell lines derived from tumors that formed from these clones in severe immunedeficient (SCID) mice.…”

Section: Subcutaneous Transplantation Modelsmentioning

confidence: 99%

Animal models for the study of squamous cell carcinoma of the upper aerodigestive tract: A historical perspective with review of their utility and limitations. Part A. Chemically‐induced de novo cancer, syngeneic animal models of HNSCC, animal models of transplanted xenogeneic human tumors

Smith

Thomas

2005

Intl Journal of Cancer

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Understanding the complex histological, genetic and molecular changes that lead to malignant transformation of squamous epithelia of the head and neck will likely guide the development of methods for improved diagnosis, monitoring and treatment of head and neck squamous cell carcinoma (HNSCC). The development and use of animal models that closely mimic the histopathology and molecular pathogenesis of HNSCC in humans would greatly expand the research possibilities and provide a means of testing potential therapeutic agents. However, many available animal models of HNSCC fall short of this objective. In order for investigators to select the appropriate model to answer scientific questions, it is important to understand the benefits and limitations of available animal models for the study of HNSCC. The purpose of this work is to give an overview of the most pertinent animal models of HNSCC, and to discuss future directions of research in this field. ' 2005 Wiley-Liss, Inc.Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. Approximately half of all patients with HNSCC have advanced stage disease at the time of diagnosis, with an expected 5-year survival rate between 10 and 40%.1 Despite treatments that may consist of mutilating surgery, radiotherapy and/or chemotherapy, overall long-term survival remains low due to uncontrollable persistent or recurrent disease. The survival rate of patients with locoregional and distant recurrences has highlighted the need for new approaches for diagnosis and treatment. To this end, a better understanding of the genetic, molecular and immunoregulatory processes leading to neoplastic transformation and progression of HNSCC is needed, so that novel and more effective diagnostic and therapeutic approaches can be designed.Although in vitro study systems are useful for studying the interactions between different cell populations in culture and are convenient and simple to use, they do not reproduce the complexity of HNSCC. For this reason, the development of new therapies will require clinically relevant animal models of HNSCC. Adequate animal models are necessary to test the translational potential of preventive and therapeutic agents, as well as to understand the biological mechanisms of epithelial carcinogenesis and progression. The ideal experimental animal tumor model for HNSCC must reproduce the characteristic features of the disease, including the complicated patterns of tumor-host interactions such as immune response, angiogenesis, invasion and metastasis. In the ideal model, clinical symptoms and laboratory abnormalities should be similar to the human disease and therapeutic agents should be as effective in both systems. The ideal model must also be easy to use, accessible to genetic and immunologic manipulations, reproducible and progress rapidly to allow timely investigations.Animal mod...

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Effect of combined adoptive immunotherapy and radiotherapy on tumor growth

Cited by 8 publications

References 18 publications

Enhancing cytokine-induced killer cell therapy of multiple myeloma

Enhancing cytokine-induced killer cell therapy of multiple myeloma

Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma

Animal models for the study of squamous cell carcinoma of the upper aerodigestive tract: A historical perspective with review of their utility and limitations. Part A. Chemically‐induced de novo cancer, syngeneic animal models of HNSCC, animal models of transplanted xenogeneic human tumors

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