Effect of combined aerobic–resistance training and subsequent detraining on brain‐derived neurotrophic factor (BDNF) and depression in women with type 2 diabetes mellitus: A randomized controlled trial

Donyaei, Adel; Kiani, E.; Bahrololoum, Hassan; Moser, Othmar

doi:10.1111/dme.15188

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…It was noted that in the MDD subgroup metabolic parameters (BMI, weight, waist circumference, fasting glucose, IR, lipid profile) and symptom severity in domains of affectivity, negative symptoms, activity as well as quality of life significantly improved with the lifestyle intervention vs. control. Donyaei et al [ 34 ▪ ] assessed the effectiveness of 12-week aerobic-resistance training program on the metabolic parameters, BDNF and severity of depression in TMD2. Initial BDI indicated that both control and experimental groups showed severe levels of depression.…”

Section: Insulin-sensitizing Drugs (Off-label)/interventions In Major...mentioning

confidence: 99%

Consolidating evidence on the role of insulin resistance in major depressive disorder

Krupa,

Dudek,

Siwek

2023

Current Opinion in Psychiatry

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Purpose of review The circular interactions between type 2 diabetes (TMD2) and major depressive disorder (MDD) are well documented but the understanding of their mechanisms has only recently gained more clarity. Latest research indicates, that the association between TMD2 and MDD is largely mediated by insulin resistance (IR). Recent findings A metabolic subtype of MDD can be distinguished from other MDD subpopulations, that is characterized by predominantly atypical clinical presentation, IR and different responsiveness to antidepressant interventions. IR is a predictor of nonresponse to some antidepressants. The IR seems to be a state-marker of clinical or subclinical depression and the relationship between IR and MDD varies between sexes and ethnicities. Insulin has a direct impact on the monoaminergic systems known to underlie MDD symptoms: serotoninergic and dopaminergic, which are dysregulated in IR subjects. Several trials assessed the efficacy of insulin-sensitizing drugs in MDD with mixed results for metformin and more consistent evidence for pioglitazone and lifestyle intervention/physical activity. Summary Recently published data suggest a significant role of IR in the clinical presentation, pathophysiology and treatment response in MDD. Further research of IR in MDD and integration of existing data into clinical practice are needed.

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Section: Insulin-sensitizing Drugs (Off-label)/interventions In Major...mentioning

confidence: 99%

Consolidating evidence on the role of insulin resistance in major depressive disorder

Krupa,

Dudek,

Siwek

2023

Current Opinion in Psychiatry

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The Optimal Type and Dose of Exercise for Elevating Brain‐Derived Neurotrophic Factor Levels in Patients With Depression: A Systematic Review With Pairwise, Network, and Dose–Response Meta‐Analyses

Yuping,

Tianbi,

Wentao

et al. 2024

Depression and Anxiety

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Background: Reduced brain‐derived neurotrophic factor (BDNF) levels have been linked to increased depression risk. While physical exercise is known to alleviate depressive symptoms and elevate BDNF levels, the effects of different exercise modalities and doses, along with their dose–response relationships, remain unclear.Objective: This study aims to systematically evaluate the effects of various exercise types and doses on BDNF levels in patients with depression through pairwise meta‐analysis, network meta‐analysis (NMA), and dose–response NMA and to provide personalized exercise prescription recommendations.Methods: A comprehensive search identified randomized controlled trials (RCTs) examining exercise’s impact on BDNF levels in depression. Pairwise and NMA compared six exercise modalities: continuous aerobic exercise (CAE), resistance exercise (RE), combined aerobic and resistance exercise (AERE), yoga, Qigong, and mindfulness. Dose–response NMA was used to assess the relationships between exercise dose and BDNF levels.Results: Thirty‐six RCTs with 2515 participants were included. The pairwise meta‐analysis indicated that all exercise interventions significantly elevated BDNF levels in patients with depression, with AERE, RE, and yoga demonstrating the most substantial effects. NMA rankings suggested that AERE was the most effective intervention, followed by RE, yoga, Qigong, mindfulness, and CAE. Dose–response NMA revealed a positive nonlinear dose–response relationship between total exercise volume and BDNF levels, with an optimal effective dose identified at ~610 METs‐min/week. Beyond 1000 metabolic equivalent of tasks (METs)‐min/week, increases in BDNF levels appeared to plateau. Moreover, each exercise type had distinct dose–response patterns, with RE and AERE having relatively higher optimal effective dose ranges, while CAE, yoga, Qigong, and mindfulness exhibited lower optimal ranges.Conclusions: AERE, RE, and yoga are effective interventions for enhancing BDNF levels in patients with depression, with Qigong, mindfulness, and CAE being comparatively less effective. A positive nonlinear dose–response relationship between exercise volume and BDNF levels was observed. Further research is needed to refine dose–response relationships in this population.

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Physical activity and mental health: a systematic review and best-evidence synthesis of mediation and moderation studies

White,

Vella,

Biddle

et al. 2024

Int J Behav Nutr Phys Act

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Background While evidence consistently demonstrates that physical activity is beneficial to mental health, it remains relatively unknown how physical activity benefits mental health, and which factors influence the effect of physical activity on mental health. This understanding could vastly increase our capacity to design, recommend, and prescribe physical activity in more optimal ways. The purpose of this study was to systematically review and synthesise evidence of all mediators and moderators of the relationship between physical activity and mental health. Methods Systematic searches of four databases (i.e., Scopus, PsycINFO, PubMed, and SPORTDiscus) identified 11,633 initial studies. Empirical studies that quantitatively assessed physical activity, or conducted a physical activity intervention, measured a mental health outcome, and tested one or more mediator or moderator of the relationship between physical activity and mental health were included. A total of 247 met the inclusion criteria; 173 studies examined mediation and 82 examined moderation. Results Results of the best-evidence synthesis revealed strong evidence for 12 mediators including affect, mental health and wellbeing, self-esteem, self-efficacy, physical self-worth, body image satisfaction, resilience, social support, social connection, physical health, pain, and fatigue. Moderate evidence was identified for a further 15 mediators and eight moderators. Conclusions Findings should inform the design of future physical activity interventions to ensure optimal effects on mental health related outcomes. Additionally, if health professionals were to take these mediators and moderators into consideration when prescribing or recommending physical activity, physical activity would likely have a greater impact on population mental health.

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Effect of combined aerobic–resistance training and subsequent detraining on brain‐derived neurotrophic factor (BDNF) and depression in women with type 2 diabetes mellitus: A randomized controlled trial

Cited by 4 publications

References 24 publications

Consolidating evidence on the role of insulin resistance in major depressive disorder

Consolidating evidence on the role of insulin resistance in major depressive disorder

The Optimal Type and Dose of Exercise for Elevating Brain‐Derived Neurotrophic Factor Levels in Patients With Depression: A Systematic Review With Pairwise, Network, and Dose–Response Meta‐Analyses

Physical activity and mental health: a systematic review and best-evidence synthesis of mediation and moderation studies

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