Effect of combined implants of oestradiol and testosterone on libido in postmenopausal women

Appleby, Louis; Montgomery, Julia

doi:10.1136/bmj.294.6584.1417-c

Cited by 2 publications

(2 citation statements)

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“…Although some studies show that the menopause worsens women's lipid profiles, the use of estradiol (E) combined with progesterone has shown worsening of the lipid profile with increase of LDL-cholesterol and cardiovascular risk [12,13]. There is an actual trend to use testosterone (T) combined with E to cause a improvement of the hypoandrogenic symptoms with an important enhancement in the quality of life of these women [14][15][16][17].…”

Section: Introductionmentioning

confidence: 97%

Improvement of the lipid profile in post menopausal women who use estradiol and testosterone implants

Britto

Araújo

Barbosa

et al. 2012

Gynecological Endocrinology

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Section: Introductionmentioning

confidence: 97%

Improvement of the lipid profile in post menopausal women who use estradiol and testosterone implants

Britto

Araújo

Barbosa

et al. 2012

Gynecological Endocrinology

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show abstract

“…Whereas some studies show that menopause causes a worsening in the lipid profile of women, the use of E combined with progesterone has shown a worsening in the lipid profile with an increase in the LDL cholesterol (LDL) and Manuscript accepted for publication December 12, 2011 a in the cardiovascular risk [13,14]. There is an actual trend of using T combined with E in order to improve the hypo androgen symptoms with an important improvement in the quality of life of these women [15][16][17][18]. Studies have already shown that this combination offers endometrial protection, without the use of progestogens needed [19].…”

Section: Introductionmentioning

confidence: 99%

Use of Androgens in Postmenopausal Women

Britto

2011

J Endocrinol Metab

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During menopause, women may experience greater loss of bone mineral density, leading to a high risk of fractures. Estradiol has great importance in the maintenance of bone micro architecture and estradiol and testosterone combination have high effectiveness in preventing osteoporosis and fractures in post menopausal women. There is an actual trend of using testosterone combined with estradiol in order to improve the hypo androgen symptoms with an important improvement in the quality of life of these women. The behavior of the lipid profile in women using this combination is not well defined once the results of the studies already made are very controversial. This review article aims at evaluating the studies made in the last years that evaluated the impact of the use of androgens in post menopause women over a bone mineral density and the lipid profile. Searches of articles were made on Pubmed from 1980 to 2011. The searches were made with the use of the keywords 'testosterone' or 'androgens' and 'postmenopausal women' and 'bone density' and 'hormone replacement therapy'. In its second phase the 'testosterone' or 'androgens' and 'postmenopausal women' and 'lipoprotein' and 'hormone replacement'. A total of 67 articles were found. After reading their whole content, 09 original articles were included in this review, prospective that evaluated bone mineral density or the lipid profile in patients using hormone therapy in post menopause. The benefits of the use of androgens have been demonstrated in publications resulting from studies with a reduced number of patients, in non-probabilistic samples, and most of them observational. On the other hand, the results converge towards an improvement of the lipid profile and increase in the bone mineral density in the patients in post menopause. The greater limitation of these results lies on the difficulty on determining the isolated effects of the androgens once the studies showed results obtained through HT with estradiol and androgens. Clinical rehearsals in comparison between the use of isolated estradiol and estardiol + testosterone shall clarify the impact of this combination under the lipid profile and bone protection in postmenopausal patients.

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Effect of combined implants of oestradiol and testosterone on libido in postmenopausal women

Cited by 2 publications

References 4 publications

Improvement of the lipid profile in post menopausal women who use estradiol and testosterone implants

Improvement of the lipid profile in post menopausal women who use estradiol and testosterone implants

Use of Androgens in Postmenopausal Women

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