Effect of combined oral contraceptive (Duofem) on platelet indices in female wistar rats

Toryila, Joseph; Amadi, K; S.A, Odeh; U.G, Egesie; A.B, Adelaiye; Mohammed, A; L.N, Achie; Denen, Atsukwei

doi:10.14419/ijbr.v2i1.1417

Cited by 1 publication

(2 citation statements)

References 5 publications

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“…Regarding hematological parameters, different results were observed by several researchers. Toryila et al 43 have reported a reduction in Hb, RBC, WBC among women using COCP compared to the controls. Jamil et al 22 showed Hb levels are normal in the OCP.…”

Section: Discussionmentioning

confidence: 96%

“…However, it was observed a significant change in Hb, WBC, and B12 after 3 years of using OCP. Similarly, Toryila et al 43 reported that long-term use of COCP might lead to more complications than short-time use. However, the long-term users of the OCP on RBC has shown no significant difference (p≥ 0.05) compared to the mean value of non-users of OCs (control group).…”

Section: Discussionmentioning

confidence: 97%

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Effect of Oral Contraceptive Pills on Oxidative Stress in Saudi women

Osman

Al-Mutairi

2021

J. Contemp. Med. Sci.

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Objective: The aim of this study was to evaluate the effect of oral contraceptive pills on oxidative stress in Saudi women. Methods: A total of fifty-five Saudi women were divided into two groups: users of oral contraceptive pills (OCP, N=30) for at least one year and non-users (NOCP, N=25). The demographic data were obtained through face-to-face interviews performed by the researcher. Blood specimen from both groups were drawn after 8 hours of fasting to estimate serum Total antioxidant (TAOC), Nitric oxide (NO), C-reactive protein (CRP), vitamins (E, B6, B12) and some hematological parameters: hemoglobin (Hb), Red blood cell (RBC), White blood cell (WBC). Results: The results showed a significant decreased in serum TAOC, NO, vitamins E and B6 accompanied with high significant increase in CRP level while no significant changes B12, HB, RBC and WBC were observed in the OCP users as compared to the control group. Conclusion: The results of this study indicated that the use of OCP resulted in low levels of the total antioxidant, nitric oxide, vitamin E, and B6 with a significant increase in CRP. Women who used OCP may be more susceptible to oxidative stress by enhanced depletion of antioxidants.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%