Effect of Combined Therapy of Danaparoid Sodium and Tranexamic Acid on Chronic Disseminated Intravascular Coagulation Associated With Abdominal Aortic Aneurysm

Emergency surgery: the big three – abdominal aortic aneurysm, laparotomy and hip fracture

“…Perioperative point-of-care testing of acid-base balance, haemoglobin concentration and coagulation status (thrombelastography) facilitate appropriate clinical decisions about fluid therapy and administration of blood products. Tranexamic acid may be of use in the treatment of fibrinolysis-dominant disseminated intravascular coagulopathy associated with AAA [27].…”

<i>Helicobacter pylori</i> Eradication Therapy for Thrombocytopenia after Surgery for Abdominal Aortic Aneurysm with Disseminated Intravascular Coagulation

“…Preoperative DIC is a severe complication; however, the therapeutic strategy in AAA with DIC remains controversial. 3,4) Since Fine et al 1) reported a case of consumptive coagulopathy of a dissected aneurysm in 1967, there have been many reports on AAA-associated coagulopathy. [2][3][4] Some reports indicate surgery for AAA enables correction of thrombocytopenia.…”

“…3,4) Since Fine et al 1) reported a case of consumptive coagulopathy of a dissected aneurysm in 1967, there have been many reports on AAA-associated coagulopathy. [2][3][4] Some reports indicate surgery for AAA enables correction of thrombocytopenia. Oba et al 3) opinioned that surgeons should not expend an undue amount of time to correct DIC preoperatively.…”

“…1,2) However, the strategy for preoperative intravenous conservative treatment is controversial. 3,4) We report a case of a large AAA (maximum diameter: 90 mm) with thrombocytopenia who underwent emergency laparotomy for abdominal aorta replacement thrombocytopenic cases such as DIC, pernicious anemia, thrombotic thrombocytopenic purpura, systemic lupus erythematosus, aortic aneurysms, and drug-induced thrombocytopenia. The patient recovered and was discharged after 1 month with an advice to undergo routine follow-up at the outpatient clinic.…”

Use of Rivaroxaban for the Effective Management of Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm

“…Previous studies have demonstrated that the effective adjunctive treatments for chronic DIC due to aortic aneurysm were: continuous heparin infusion (11), subcutaneous injection of low molecular weight heparin (6,(12)(13)(14), the intravenous injection of danaparoid with the oral administration of tranexamic acid (15), and thrombomodulin (16,17) with or without platelet and FFP transfusion for the acute phase of exacerbation of chronic DIC. However, the intravenous or subcutaneous administration of these medicines for the prevention of an exacerbation of chronic DIC in outpatients for an extended period of time is difficult.…”