Effect of Combined Transient Androgen Deprivation and Irradiation Following Radical Prostatectomy for Prostatic Cancer

Predictive factors of radiation therapy for patients with prostate specific antigen recurrence after radical prostatectomy

“…as salvage therapy for patients who have a local recurrence confirmed on biopsy or on PSA velocity, or as adjuvant therapy for patients with adverse pathology. In studies with a long follow-up the 3-year biochemical progression-free survival is 24-67% (51% in the present study) and the 5-year biochemical progression-free survival 10-88% (Table 4) [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

“…Taken together, these studies indicate that whereas pelvic RT after RP can control local disease, the survival outcome is dominated by the probability of developing metastatic disease. The association of hormonal therapy and RT was proposed to most of our patients because they had a high risk of recurrence, and because this association was suggested by several published studies [5,8,9,12]. Only a few studies have investigated the predictive factors for local recurrence after RP (Table 4).…”

“…Because some factors could be interdependent, multivariate analysis was used to determine which variable retained significance (Table 3) [4][5][6][7][8][9]. This analysis showed that only Gleason score ( P = 0.0395) and nadir serum PSA after RT ( P = 0.028) were independent predictive factors of salvage/adjuvant RT.…”

“…For patients with presumed local recurrence or persistent prostate cancer based on PSA velocity or adverse pathology, radiation therapy (RT) as an adjuvant or a salvage treatment has been reported as a therapeutic option, with several studies publishing the outcome [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. However, only a few studies tried to identify the predictive factors of biochemical progression in patients with PSA recurrence after RP and treated with RT [4][5][6][7][8][9].…”

“…However, only a few studies tried to identify the predictive factors of biochemical progression in patients with PSA recurrence after RP and treated with RT [4][5][6][7][8][9]. We reviewed retrospectively our experience of salvage RT after RP and tried to define the best candidates for this therapeutic option, based on our experience and a literature review.…”