Effect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus: a propensity score-based analysis

Ohmura, Koichiro; Kato, Masaaki; Watanabe, Toshiyuki; Oku, Kenji; Bohgaki, Toshiyuki; Horita, Tetsuya; Yasuda, Shinsuke; Ito, Yoichi M.; Sato, Norihiro; Atsumi, Tatsuya

doi:10.1186/s13075-018-1589-9

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…Unfortunately, at the moment, the results for its supplementation in neurological disorders, in particular concerning data on vitamin supplementation and their progression or eventual real clinical benefits are inconclusive. As such, there is a strong need for randomized clinical trials on neurodegenerative patients and vitamin D supplementation, to optimize time, efficacy, and appropriate monitoring [ 240 , 241 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

IJMS

137

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It is widely known that vitamin D receptors have been found in neurons and glial cells, and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. Vitamin D helps the regulation of neurotrophin, neural differentiation, and maturation, through the control operation of growing factors synthesis (i.e., neural growth factor [NGF] and glial cell line-derived growth factor (GDNF), the trafficking of the septohippocampal pathway, and the control of the synthesis process of different neuromodulators (such as acetylcholine [Ach], dopamine [DA], and gamma-aminobutyric [GABA]). Based on these assumptions, we have written this review to summarize the potential role of vitamin D in neurological pathologies. This work could be titanic and the results might have been very fuzzy and even incoherent had we not conjectured to taper our first intentions and devoted our interests towards three mainstreams, demyelinating pathologies, vascular syndromes, and neurodegeneration. As a result of the lack of useful therapeutic options, apart from the disease-modifying strategies, the role of different risk factors should be investigated in neurology, as their correction may lead to the improvement of the cerebral conditions. We have explored the relationships between the gene-environmental influence and long-term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation.

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Section: Discussionmentioning

confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

IJMS

137

View full text Add to dashboard Cite

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“…Finally, increased bone metabolism itself can be responsible for the association between osteoporosis and atherosclerosis. Evidence from bisphosphonate studies has shown that the inhibition of osteoclast function with bisphosphonate has an anti-atherosclerotic effect in both the normal population and lupus patients [30,31]. Considering bisphosphonate accumulates mainly in bone by binding to hydroxyapatite crystals [32], the decreased bone metabolism by bisphosphonate and the consequent reduction of calcium-phosphate efflux or serum osteocalcin, an osteoblast-derived bone Gla (γ-carboxyglutamic acid-containing) protein, can attenuate the progression of atherosclerosis [33,34].…”

Section: Discussionmentioning

confidence: 99%

Radial BMD and serum CTX-I can predict the progression of carotid plaque in rheumatoid arthritis: a 3-year prospective cohort study

et al. 2021

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Objective Patients with rheumatoid arthritis (RA) are almost twice as likely to develop cardiovascular disease (CVD) as those without. However, traditional CVD risks have been shown to underperform in RA patients; thus, we aimed to identify new surrogate risk factors to better reflect their atherosclerotic burden. Methods A total of 380 RA patients with carotid atherosclerosis data were analyzed in this prospective cohort study. The primary outcome was carotid plaque progression over the 3-year follow-up period. Risk parameters assessed for the progression of carotid plaque were categorized as demographics, traditional CVD risks, RA-related risks, and bone parameters. Results The progression of carotid plaque was associated with the level of rheumatoid factor (p = 0.025), serum C-terminal telopeptide of type-I collagen (CTX-I) (p = 0.014), and femur and distal radius bone mass density (BMD) (p = 0.007 and 0.004, respectively), as well as traditional CVD risk factors. In multivariable analyses, the bone parameters of serum CTX-I and distal radius BMD proved to be independent predictors of the progression of carotid plaque along with hyperlipidemia, smoking, and baseline carotid plaque (all, p < 0.05). Adding both serum CTX-I and distal radius BMD increased the carotid plaque progression prediction model’s percentage of explained variance from 24 to 30%. Conclusion High serum CTX-I and lower radius BMD, reflecting high bone turnover, were independent risk factors for the progression of carotid plaque in RA patients, implicating the direct or indirect role of bone metabolism on the atherosclerotic burden.

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“…Finally, increased bone catabolism itself can be responsible for the association between osteoporosis and atherosclerosis. Evidence from bisphosphonate studies has shown that the inhibition of osteoclast function with bisphosphonate has an anti-atherosclerotic effect in both the normal population and lupus patients [30,31]. Considering bisphosphonate accumulates mainly in bone by binding to hydroxyapatite crystals [32], the decreased bone catabolism by bisphosphonate and the consequent reduction of calcium-phosphate e ux or serum osteocalcin, an osteoblast-derived bone Gla (γ-carboxyglutamic acid-containing) protein, can attenuate the progression of atherosclerosis [33,34].…”

Section: Discussionmentioning

confidence: 99%

Radial BMD and serum CTX-I can Predict the Progression of Carotid Plaque in Rheumatoid Arthritis: A 3-year Prospective Cohort Study

Han

Kim

Kang

et al. 2021

Preprint

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Objective. Patients with rheumatoid arthritis (RA) are almost twice as likely to develop cardiovascular disease (CVD) as those without. However, traditional CVD risks have been shown to underperform in RA patients; thus, we aimed to identify new surrogate risk factors to better reflect their atherosclerotic burden.Methods. A total of 380 RA patients with carotid atherosclerosis data were analyzed in this prospective cohort study. The primary outcome was carotid plaque progression over the 3-year follow-up period. Risk parameters assessed for the progression of carotid plaque were categorized as demographics, traditional CVD risks, RA-related risks, and bone parameters. Results. The progression of carotid plaque was associated with the level of rheumatoid factor (p = 0.025), serum C-terminal telopeptide of type-I collagen (CTX-I) (p = 0.014), and femur and distal radius bone mass density (BMD) (p = 0.007 and 0.004, respectively), as well as traditional CVD risk factors. In multivariable analyses, the bone parameters of serum CTX-I and distal radius BMD proved to be independent predictors of the progression of carotid plaque along with hyperlipidemia, smoking, and baseline carotid plaque (all, p < 0.05). Adding both serum CTX-I and distal radius BMD increased the carotid plaque progression prediction model’s percentage of explained variance from 24% to 30%.Conclusion. High serum CTX-I and lower radius BMD, reflecting high bone turnover, were independent risk factors for the progression of carotid plaque in RA patients, implicating the direct or indirect role of bone catabolism on the atherosclerotic burden.

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Effect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus: a propensity score-based analysis

Cited by 8 publications

References 24 publications

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Radial BMD and serum CTX-I can predict the progression of carotid plaque in rheumatoid arthritis: a 3-year prospective cohort study

Radial BMD and serum CTX-I can Predict the Progression of Carotid Plaque in Rheumatoid Arthritis: A 3-year Prospective Cohort Study

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