Effect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical Trial

Masoumi, Seyedeh Zahra; Ataollahi, Maryam; Oshvandi, Khodayar

doi:10.15171/jcs.2016.007

Cited by 20 publications

(19 citation statements)

References 15 publications

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“…The other study was performed in 2016 that students in a group received combined vitamin B6 (40 mg) and calcium (500 mg) and in other group only vitamin B6 twice a day. The result showed that although the severity of symptoms decreased in both groups, this reduction was more significant in the combined calcium and vitamin B6 group [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of calcium on premenstrual syndrome: A double-blind randomized clinical trial

et al. 2017

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ObjectivePremenstrual syndrome (PMS) affects millions of women and is known as the most important disorder among them. The very aim of the present study was to evaluate the effects of low dose calcium on severity of PMS.MethodsThis study can be considered as a double-blind randomized clinical trial. Female students of Hamadan University of Medical Sciences diagnosed with PMS in 2014 participated in the present study. Sixty-six female students diagnosed with PMS were involved in the experimental and control groups. The participants were randomly assigned into two groups to receive 500 mg of calcium daily or placebo for two months. Severity of PMS was detected by Daily Record of Severity of Problems, which was used to measure symptoms during one menstrual cycle before and two menstrual cycles after the intervention.ResultsNo signifcant differences were observed in the mean scores of PMS symptoms between calcium and placebo groups before the treatment (P=0.74). However, signifcant differences were noticed between the two intervention groups in the first (P=0.01) and second menstrual cycles (P=0.001) after the intervention. The differences were significant in subgroups of anxiety, depression, emotional changes, water retention, and somatic changes in calcium group compared with placebo group in the menstrual cycle before the intervention and two menstrual cycles after the intervention and among menstrual cycles (0, cycle 1, cycle 2) in calcium group (P=0.01).ConclusionOverall, the results of the present study suggest that treatment with calcium supplements is an effective method for reducing mood disorders during PMS.

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Section: Discussionmentioning

confidence: 99%

“…Some studies have reported significant effect of 1,000 mg of calcium supplement on decrease of PMS [ 4 12 13 ]. The calcium effect on PMS is correlated to the production of serotonin and tryptophan metabolism [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of calcium on premenstrual syndrome: A double-blind randomized clinical trial

et al. 2017

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“…Both physical and psychological symptoms of PMS have significant negative impact on health and quality of life in women 3 . PMS is more common in young women, and according to the WHO, PMS is a public health threat in the modern societies 4 . Around 70–90% of females in their productivity period show at least one of the PMS symptoms.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Supplementation for Premenstrual Syndrome-Related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial

Heidari

Amani

Feizi

et al. 2019

Sci Rep

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Premenstrual syndrome (PMS) is a common disorder in the reproductive age that negatively significant impacts on women’s quality of life. This randomized clinical trial study was undertaken to investigate the effect of vitamin D supplementation on inflammatory and antioxidant markers in 44 vitamin D deficient (25(OH)D < 20 ng/mL) students with PMS. Participants received either 50,000 IU vitamin D3 or a placebo pearl fortnightly for 4 months. At the baseline and in the last 2 months of intervention, participants were asked to complete the PMS Daily Symptoms Rating form along with taking the pearls and their blood samples were collected to assess serum levels of 25(OH)D3, Interleukin10 and 12 (IL-10, IL-12) and total antioxidant capacity (TAC). In vitamin D group, serum levels of IL-10 and IL-12 significantly decreased while TAC significantly increased post-intervention. There were significant differences regarding serum IL-12 and TAC levels between the two groups. Mean score of the total PMS symptoms showed significant improvement in 25(OH)D. Vitamin D supplementation seems to be an effective strategy to improve inflammation and antioxidant markers in vitamin D deficient women with PMS. This clinical trial was registered at Iranian Registry of Clinical Trials on 20/06/2018 (IRCT20180525039822N1).

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“…Thus, it can reduce the incidence rate of postoperative complications in patients with CA ( 8 ). Vitamin B6, as a member of the vitamin B family, can regulate glycogen metabolism, participate in the transformation of unsaturated fatty acids and the synthesis of neural medium, and improve the postoperative mental state of patients ( 9 ). However, there is a lack of related randomized controlled trials in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm

Chen

Lei

2018

Exp Ther Med

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The aim of the present study is to investigate whether glycerol fructose combined with vitamin B6 is beneficial to the postoperative recovery of patients with cerebral aneurysm (CA). A total of 134 patients receiving embolization of CA in the Central Hospital of Wuhan between February, 2013 and June, 2015 and were divided into observation and control groups according to the random number table method, with 67 cases in each group. The control was given vitamin B6 routine treatment, while the observation group received glycerol fructose on the basis of treatment in the control group. The incidence rate of postoperative complications after treatment, Glasgow coma scale (GCS) score, Barthel index score, and neurological fatigue index (NFI) score were compared between the two groups. After treatment, the GCS, Barthel index and NFI scores of patients in the observation were better than those in the control group (p<0.05), and the Barthel index score in the observation group was significantly higher than that in the control group (p<0.01). The mean flow velocity of middle cerebral artery (MCA) in the observation group after treatment was significantly different from that in the control group (p<0.05). As for complications, the incidence rates of postoperative cerebral vasospasm (1.49%), cerebral ischemia (1.49%), hematoma at puncture site (2.98%) and aneurysm rupture and hemorrhage (4.47%) in the observation group were lower than those of cerebral vasospasm (8.95%), cerebral ischemia (7.46%), hematoma at puncture site (8.95%) and aneurysm rupture and hemorrhage (10.44%) in the control group, and the differences were statistically significant (p<0.05). In conclusion, glycerol fructose combined with vitamin B6 can reduce the incidence rate of postoperative complications and improve patients self-care ability and quality of life. Therefore, it is beneficial to postoperative recovery and it is worthy of clinical application.

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Effect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical Trial

Cited by 20 publications

References 15 publications

Effect of calcium on premenstrual syndrome: A double-blind randomized clinical trial

Effect of calcium on premenstrual syndrome: A double-blind randomized clinical trial

Vitamin D Supplementation for Premenstrual Syndrome-Related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial

Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm

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