Effect of Combining Erythrosine with a High-Power Dental Curing Light Appliance on the Viability of a Planktonic Culture of<i>Streptococcus mutans</i>

Romão, Iasmym Queiroz; Cavalcante, Salma Ivanna Araújo; Leite, Hadda Lyzandra Austríaco; Gonçalves, Letícia Machado; Branco-de-Almeida, Luciana Salles; Paschoal, Marco Aurélio Benini

doi:10.1089/pho.2018.4517

Cited by 15 publications

(10 citation statements)

References 28 publications

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“…Several studies have already demonstrated the susceptibility of cariogenic bacteria to photodynamic therapy [39,52,53], suggesting that this therapy may be useful as a minimally invasive adjuvant therapy for the control of dental caries [54] through cariogenic bacteria inactivation [55].…”

Section: Discussionmentioning

confidence: 99%

Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Oliveira

Ferrisse

Marques

et al. 2019

IJMS

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The aim of this study was to perform a systematic review of the literature followed by a meta-analysis about the efficacy of photodynamic therapy (PDT) on the microorganisms responsible for dental caries. The research question and the keywords were constructed according to the PICO strategy. The article search was done in Embase, Lilacs, Scielo, Medline, Scopus, Cochrane Library, Web of Science, Science Direct, and Pubmed databases. Randomized clinical trials and in vitro studies were selected in the review. The study was conducted according the PRISMA guideline for systematic review. A total of 34 articles were included in the qualitative analysis and four articles were divided into two subgroups to perform the meta-analysis. Few studies have achieved an effective microbial reduction in microorganisms associated with the pathogenesis of dental caries. The results highlight that there is no consensus about the study protocols for PDT against cariogenic microorganisms, although the results showed the PDT could be a good alternative for the treatment of dental caries.

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Section: Discussionmentioning

confidence: 99%

Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Oliveira

Ferrisse

Marques

et al. 2019

IJMS

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“…PDT was performed with the application of erythrosine (200 µM) as FS, sensitized with high-intensity LED with a wavelength between 500 and 550 nm, the highest absorption range for erythrosine ( 21 ). The choice of FS was due to the promising results reported in other studies ( 12 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…In this sense, erythrosine is an FS agent widely used due to its low toxicity and effectiveness in inhibiting the activity of oral gram-positive and gram-negative microorganisms and is approved by the Food and Drug Association for use in food products and in dentistry. In addition, it has an absorption peak very close to the emission of light sources used in dental offices (LED or halogen light sources with wavelengths between 500 and 550 nm), allowing the inclusion of this practice in the dental context ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial action of ozonated water and photodynamic therapy with sonic activation in root canals infected with Enterococcus faecalis

Nunes¹,

Novais²,

Garcia³

et al. 2022

J Clin Exp Dent

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“…To date there have been no thorough short or long-term investigation of PS-loaded dental materials reported in the literature. [25][26][27][28][29] A potential photosensitizer of interest is Ruthenium (Ru), a safe transition metal in group VIII. [30][31][32][33] It has been applied in several biomedical fields, showing in vitro 34,35 and in vivo 36 biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…To date there have been no thorough short or long-term investigation of PS-loaded dental materials reported in the literature. 25–29…”

Section: Introductionmentioning

confidence: 99%

Exploring the use of a Ruthenium complex incorporated into a methacrylate-based dental material for antimicrobial photodynamic therapy

Manso

Leite

Comeau

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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Objectives: To evaluate the effects of a blue light photosensitizer (PS), Ruthenium II complex (Ru), on the chemical, physical, mechanical, and antimicrobial properties of experimental dental resin blends. Methods: The experimental resin (BisEMA, TEEGDMA, HPMA, ethanol, and photoinitiator) was loaded with Ru at 0.00%, 0.07%, 0.14%, 0.28%, 0.56%, 1.12%, 1.2%, 1.5%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, or 10% w/w. Samples were evaluated for the degree of conversion (DC) after 30 and 60 s curing-time ( n = 6). Selected formulations (0.00%, 0.28%, 0.56%, 1.12%) were further tested for shear bond strength (SBS) ( n = 15); flexural strength (FS) ( n = 12); and antimicrobial properties (CFUs), in dark and light conditions. These latter tests were performed on specimens stored for 24-h or 2-month in 37°C water. Water sorption (WS) and solubility (SL) tests were also performed ( n = 12). Data were analyzed either by a one- or two-factor general linear model (α = 0.05). Results: Overall, Ru concentration above 1.2% resulted in reduced DC. In SBS results, only the 1.12%Ru resin blend samples had statistically lower values compared to the 0.00%Ru resin blend at 24-h storage ( p = 0.004). In addition, no differences in SBS were detected among the experimental groups after 2-month storage in water. Meanwhile, FS increased for all experimental groups under similar aging conditions ( p < 0.001). Antimicrobial properties were improved upon inclusion of Ru and application of light ( p < 0.001 for both) at 24-h and 2-month storage. Lastly, no detectable changes in WS or SL were observed for the Ru-added resins compared to the 0.00%Ru resin blend. However, the 0.28% Ru blend presented significantly higher WS compared to the 0.56% Ru blend ( p = 0.007). Conclusions: Stable SBS, improved FS, and sustained antimicrobial properties after aging gives significant credence to our approach of adding the Ruthenium II complex into dental adhesive resin blends intended for an aPDT approach.

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Effect of Combining Erythrosine with a High-Power Dental Curing Light Appliance on the Viability of a Planktonic Culture ofStreptococcus mutans

Cited by 15 publications

References 28 publications

Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Antimicrobial action of ozonated water and photodynamic therapy with sonic activation in root canals infected with Enterococcus faecalis

Exploring the use of a Ruthenium complex incorporated into a methacrylate-based dental material for antimicrobial photodynamic therapy

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