“…The formulation of toothpastes includes numerous inactive ingredients, with different functions, as thickening agents (xanthan gum, carrageenan), humectants (glycerin), abrasive bases (calcium carbonate, silica, hydrated silica), foaming agents (lauryl glycoside, sodium lauroyl sarcosinate, and sodium lauryl sulphate), preservatives (sodium benzoate), sweeteners, flavors and water as the solvent. The mouthwashes also contain a plethora of inactive ingredients like solvents (water, ethanol, glycerin, propylene glycol, PEG 40), surfactants (PEG-40 hydrogenated castor oil), preservatives, sweeteners and flavors [ 166 , 185 ]. All these compounds in both kinds of toothpastes and mouthwashes can influence the release of actives and impact the quality of the product.…”