Effect of Commercially Available Wound Irrigation Solutions on Uninfected Host Tissue in a Murine Model

Powell, Dexter; Comer, Brendan; Wu, Bin; Dietz, Paula; Bou-Akl, Therese; Ren, Wei-ping; Markel, David C.

doi:10.1016/j.artd.2023.101300

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…However, for those without such contraindications, the solution has been demonstrated to be safe for human tissue. Multiple tests and reports, including NAMSA Toxicology Reports and ISO Intramuscular Implantation Tests with Histopathology, have confirmed its non-irritant nature and its promotion of normal wound healing [ 14 , 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

Impact of a Novel Antiseptic Lavage Solution on Acute Periprosthetic Joint Infection in Hip and Knee Arthroplasty

Andriollo,

Sangaletti,

Velluto

et al. 2024

JCM

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Background: Periprosthetic joint infection (PJI) represents a challenge following hip or knee arthroplasty, demanding immediate intervention to prevent implant failure and systemic issues. Bacterial biofilm development on orthopedic devices worsens PJI severity, resulting in recurrent hospitalizations and significant economic burdens. The objective of this retrospective cohort study is to evaluate the efficacy of this novel antiseptic solution, never previously evaluated in vivo, in managing early post-operative or acute hematogenous PJI following primary hip and knee joint replacements. Methods: The inclusion criteria consist of patients with total hip arthroplasty (THA) or knee arthroplasty diagnosed with acute PJI through preoperative and intraoperative investigations, in accordance with the MSIS ICM 2018 criteria. The minimum required follow-up was 12 months from the cessation of antibiotic therapy. This novel antiseptic lavage solution is composed of ethanol, acetic acid, sodium acetate, benzalkonium chloride and water. Data included demographic characteristics, diagnostic criteria, surgical techniques, post-operative treatment and follow-up outcomes. Results: A total of 39 patients treated with Debridement, Antibiotics Pearls and Retention of the Implant (DAPRI) procedures using this solution between May 2021 and April 2023 were analyzed. At a mean follow-up of 24.6 ± 6.4 months, infection recurrence-free survival rates were 87.2%, with no local allergic reactions or relevant systemic adverse effects detected. Persistent PJI necessitated two-stage revision surgery. Conclusions: This novel antiseptic lavage solution shows promise as an adjunctive tool in the treatment of PJI, demonstrating support in infection control while maintaining a favorable safety profile.

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Section: Methodsmentioning

confidence: 99%