Effect of Competitive Marathon Cycling on Plasma N-Terminal Pro-Brain Natriuretic Peptide and Cardiac Troponin T in Healthy Recreational Cyclists

Neumayr, Günther; Pfister, Rudolf; Mitterbauer, G.; Eibl, Guenther; Hoertnagl, H.

doi:10.1016/j.amjcard.2005.04.054

Cited by 95 publications

(62 citation statements)

References 20 publications

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“…Our results are thus in line with the biomarker levels observed in various studies focusing on the effects of strenuous exercise [14]. Our multi-marker, the greatest originality of this study, approach allows us, however, to seek links between marker variations in individual athletes.…”

Section: Discussionsupporting

confidence: 86%

“…Renal impairment is commonly observed after strenuous exercise. For example, in a study of 16 well-trained recreational cyclists participating in a 525 km extreme ultramarathon cycling (cumulative altitude: 12,600 m), Neumayr et al [14] observed an average 20% rise in serum creatinine (as compared to 29% in our study at T1) and 40% rise in uric acid (34% in our study at T1). In a study of 70 marathon runners, Mingels et al [48] observed a 41% increase in serum creatinine and a 21% increase in cystatin C (vs. 26% for our cyclists).…”

Section: Discussionsupporting

confidence: 48%

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Release of Cardiac Biomarkers during a Cycling Race

Goff¹,

Kaux²,

D’Otreppe³

et al. 2016

WJCD

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Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aimed to see if the relatively cardiospecific biomarkers could show the damage on cardiac muscle cells. Methods: Fourteen cyclists were recruited for an international race (177 km). We studied different cardiac biomarkers, renal function markers and blood cytology. The subjects were submitted to three blood test: one before (T0), one just after (T1) and the last one 3 hours after the race (T3). Results: Blood cytology markers, namely erythrocytes, hemoglobin, hematocrit, and average hemoglobin concentration, were found to evolve in a similar way. Renal function markers, such as creatinin, cystatin C and uric acid, showed a post effort increase that might be related to renal blood flow depletion during exercise. Cardiac and muscular markers were all increased at T1. Conclusions: Physiological stress induced by an international cycling race certainly has consequences on cardiac muscle cells. Fortunately, those blood concentration variations are more representative of a transitional state, due to an imbalance created by an intense aerobic effort maintained during several hours, rather than an irreversible injury.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 48%

Release of Cardiac Biomarkers during a Cycling Race

Goff¹,

Kaux²,

D’Otreppe³

et al. 2016

WJCD

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show abstract

“…[19][20][21][22] Less well-documented, to our awareness, are the potential effects on levels of these peptides of ethnicity (discussed below) and exercise. Although exercise may stimulate a rise in plasma natriuretic peptide levels, 23,24 our study was an observational one and confounding by unmeasured variables cannot be ruled out. One should seek confirmation of our findings in experimental studies of hypertensive and normotensive subjects before accepting that regular exercise reduces plasma natriuretic peptide levels in the long term.…”

Section: Discussionmentioning

confidence: 94%

Plasma N terminal pro-brain natriuretic peptide levels and its determinants in a multi-ethnic population

et al. 2007

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This study documents the determinants and plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) among hypertensive and normotensive subjects in a multi-ethnic population in the United Arab Emirates (UAE). We obtained demographic, anthropometric and clinical data, together with fasting NT-proBNP and biochemical indices from 128 hypertensive patients and 138 normotensive subjects matched for age, gender and ethnicity. Plasma NT-proBNP levels were significantly (Po0.001), and several-fold higher among hypertensives (median 5.92, inter quartile range (IQR): 1.79-18.48 pmol/l) than normotensives (median 1.78, IQR: 0.59-4.32 pmol/l) in the total study population, and the same was true for the ethnic groups separately. Similarly, plasma levels of glucose, blood urea nitrogen (BUN) and creatinine, but not insulin, were significantly (Po0.05) higher among hypertensives than normotensives. For all subjects combined, log NT-proBNP correlated positively and significantly with age (Po0.01), log glucose (Po0.05), systolic blood pressure (SBP, Po0.001), log BUN (Po0.001) and log creatinine (Po0.001). Multivariate regression analysis showed that NT-proBNP levels were independently and positively correlated with SBP, age, gender, log BUN, Emirati and South East Asian ethnic groups and inversely associated with current exercise. In conclusion, we found circulating levels of NT-proBNP to be significantly increased in hypertensive versus normotensive subjects in the UAE and independently related to SBP, age, gender, indices of renal function and possibly exercise. Our results further suggest a possible modulating effect of ethnicity on NT-proBNP levels.

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“…The exercise-induced increase in troponin could be due to release of cytoplasmic cTnT and cTnI, because exercise may increase membrane permeability of cardiomyocytes (19,20 ). This reversible membrane leakage might be due to increased mechanical stress on the cardiomyocytes, overload with free radicals, increased body temperature, or prolonged acidosis (19,21 ).…”

Section: Biomarker Changes After Strenuous Exercisementioning

confidence: 99%

Biomarker Changes after Strenuous Exercise Can Mimic Pulmonary Embolism and Cardiac Injury—A Metaanalysis of 45 Studies

et al. 2015

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BACKGROUND: Biomarkers are well established for diagnosis of myocardial infarction [cardiac troponins, highsensitivity cardiac troponins (hs-cTn)], exclusion of acute and chronic heart failure [B-type natriuretic peptide (BNP), N-terminal proBNP (NT-proBNP)] and venous thromboembolism (D-dimers). Several studies have demonstrated acute increases in cardiac biomarkers and altered cardiac function after strenuous sports that can pretend a cardiovascular emergency and interfere with state-of-the-art clinical assessment.

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Effect of Competitive Marathon Cycling on Plasma N-Terminal Pro-Brain Natriuretic Peptide and Cardiac Troponin T in Healthy Recreational Cyclists

Cited by 95 publications

References 20 publications

Release of Cardiac Biomarkers during a Cycling Race

Release of Cardiac Biomarkers during a Cycling Race

Plasma N terminal pro-brain natriuretic peptide levels and its determinants in a multi-ethnic population

Biomarker Changes after Strenuous Exercise Can Mimic Pulmonary Embolism and Cardiac Injury—A Metaanalysis of 45 Studies

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