Effect of Computer-Assisted Interviewing on Self-Reported Sexual Behavior Data in a Microbicide Clinical Trial

Gorbach, Pamina M.; Mensch, Barbara S.; Husnik, Marla; Coly, Astou; Mâsse, Benoı̂t; Makanani, Bonus; Nkhoma, Chiwawa; Chinula, Lameck; Tembo, Tchangani; Mierzwa, Stan; Reynolds, Kimberly; Hurst, Stacey; Coletti, Anne; Forsyth, Andrew D.

doi:10.1007/s10461-012-0302-2

Cited by 59 publications

(64 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Existing evidence on the inclusion of an audio component in computerized surveying is mixed. Some studies that compared audio-enhanced computer surveys to interviewer-administered surveys found higher prevalence rates of sensitive behaviors in computerized interviews (e.g., Des Jarlais et al, 1999;Gorbach et al, 2013;Kelly, Soler-Hampejsek, Mensch, & Hewett, 2013;Turner et al, 1998;Yeganeh et al, 2013). However, these studies confounded the effects of audio-enhancement with self-administration.…”

Section: Procedural Characteristicsmentioning

confidence: 99%

Disclosure of sensitive behaviors across self-administered survey modes: a meta-analysis

2014

View full text Add to dashboard Cite

In surveys, individuals tend to misreport behaviors that are in contrast to prevalent social norms or regulations. Several design features of the survey procedure have been suggested to counteract this problem; particularly, computerized surveys are supposed to elicit more truthful responding. This assumption was tested in a meta-analysis of survey experiments reporting 460 effect sizes (total N =125,672). Self-reported prevalence rates of several sensitive behaviors for which motivated misreporting has been frequently observed were compared across self-administered paper-andpencil versus computerized surveys. The results revealed that computerized surveys led to significantly more reporting of socially undesirable behaviors than comparable surveys administered on paper. This effect was strongest for highly sensitive behaviors and surveys administered individually to respondents. Moderator analyses did not identify interviewer effects or benefits of audio-enhanced computer surveys. The meta-analysis highlighted the advantages of computerized survey modes for the assessment of sensitive topics.

show abstract

Section: Procedural Characteristicsmentioning

confidence: 99%

Disclosure of sensitive behaviors across self-administered survey modes: a meta-analysis

2014

View full text Add to dashboard Cite

show abstract

“…However, after the failure of several large vaginal microbicide trials to demonstrate efficacy (i.e., the Carraguard trial 15 , HPTN 035 16 , and VOICE 17 ), the concern was raised that rectally acquired HIV may contribute significantly to HIV incidence among women and that method failure in these trials may have partially been due to the focus on a single orifice, the vagina, for prevention. Because women have multiple orifices available for sexual activity, including the mouth, vagina, or rectum, and recent reports have noted higher practice of AI with more confidential modes of reporting, 18 prevention methods for women will to need to be safe and acceptable for use in multiple orifices 19 .…”

Section: Introductionmentioning

confidence: 99%

Order of Orifices

Gorbach

Pines

Javanbakht

et al. 2014

JAIDS Journal of Acquired Immune Deficiency Syndromes

Self Cite

View full text Add to dashboard Cite

Background For women the order of penile insertion, condom use, and ejaculation by orifice during sexual events affects the probability of HIV transmission and design of HIV prevention methods. Methods From October 2006-June 2009, 431 women in Los Angeles and Baltimore in a rectal health study reported the sequence of penile insertion, condom use, and ejaculation by orifice location by computer assisted self-interview. Multinomial logistic regression identified predictors of condom use by orifice among women who reported vaginal intercourse (VI) during their last anal intercourse (AI) event. Results Of the 192 reporting on a last AI event, 96.3% (180/187) reported VI. Of these, 83.1% had VI before AI; 66.1% reported ejaculation during VI and 45.2% during AI. Only one third used a condom for both VI and AI, less than 10% for VI only or AI only; and half used no condoms. After adjusting for race, partner type, and substance use, compared to women who used condoms for both VI and AI at last AI, being older (units=5 years) (adjusted odds ratio [AOR]=0.76, 95% confidence interval [CI]: 0.60, 0.96), with serodiscordant partners (AOR=0.22, 95% CI: 0.08, 0.61) and HIV-positive with seroconcordant partners (AOR = 0.15; 95% CI: 0.04, 0.54) were inversely associated with non-condom use. Conclusions For most of the women in our study VI accompanied AI, with AI usually occurring after VI. This evidence for use of multiple orifices during the same sexual encounter and low use of condoms across orifices supports the need for a multi-compartment HIV prevention strategy.

show abstract

“…ACASI did not improve the accuracy of self-reported product use compared with FTFI in VOICE, despite previous research indicating that ACASI is liked by participants and may increase reports of sensitive behaviours. However, in many earlier studies assessing ACASI, there was no biomarker to objectively determine the behaviour of interest; when there was, ACASI did not fare much better than FTFI [32–34]. In the iPrEx trial, CASI and FTFI provided similarly inflated estimates of pill adherence, and were poor predictors of drug detection, with important variations by geographical areas [24].…”

Section: Discussionmentioning

confidence: 99%

Divergent adherence estimates with pharmacokinetic and behavioural measures in the MTN‐003 (VOICE) study

Straten

Brown

Marrazzo

et al. 2016

Journal of the International AIDS Society

View full text Add to dashboard Cite

IntroductionIn the Microbicide Trial Network MTN-003 (VOICE) study, a Phase IIB pre-exposure prophylaxis trial of daily oral or vaginal tenofovir (TFV), product adherence was poor based on pharmacokinetic (PK) drug detection in a random subsample. Here, we sought to compare behavioural and PK measures of adherence and examined correlates of adherence misreporting.MethodsWe included participants with PK and behavioural data from VOICE random subsample. Behavioural assessments included face-to-face interviews (FTFI), audio computer-assisted self-interviewing (ACASI) and pharmacy-returned product counts (PC). TFV concentrations <0.31 ng/mL in plasma (oral group) and <8.5 ng/swab in vaginal group were defined as “PK non-adherent.” Logistic regression models were fit to calculate the combined predictive ability of the behavioural measures as summarized by area under the curve (AUC). Baseline characteristics associated with over-reporting daily product use relative to PK measures was assessed using a Generalized Linear Mixed Model.ResultsIn this random adherence cohort of VOICE participants assigned to active products, (N=472), PK non-adherence was 69% in the oral group (N=314) and 65% in the vaginal group (N=158). Behaviourally, ≤10% of the cohort reported low/none use with any behavioural measure and accuracy was low (≤43%). None of the regression models had an AUC >0.65 for any single or combined behavioural measures. Significant (p<0.05) correlates of over-reporting included being very worried about getting HIV and being unmarried for the oral group; whereas for the vaginal group, being somewhat worried about HIV was associated with lower risk of over-reporting.ConclusionsPK measures indicated similarly low adherence for the oral and vaginal groups. No behavioural measure accurately predicted PK non-adherence. Accurate real-time measures to monitor product adherence are urgently needed.Trial registration: ClinicalTrials.gov identifier: NCT00705679

show abstract

Effect of Computer-Assisted Interviewing on Self-Reported Sexual Behavior Data in a Microbicide Clinical Trial

Cited by 59 publications

References 34 publications

Disclosure of sensitive behaviors across self-administered survey modes: a meta-analysis

Disclosure of sensitive behaviors across self-administered survey modes: a meta-analysis

Order of Orifices

Divergent adherence estimates with pharmacokinetic and behavioural measures in the MTN‐003 (VOICE) study

Contact Info

Product

Resources

About