Effect of Conclevan on Endurance Capacity in Mice

Ikarashi, Nobutomo; Fukazawa, Yoko; Toda, Takahiro; Ishii, Makoto; Ochiai, Wataru; Usukura, Masatoshi; Sugiyama, Kiyoshi

doi:10.1248/bpb.35.231

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…Forced swimming tests were conducted weekly using the method described by Ikarashi et al [16] for 4 weeks. Tests were conducted in an acrylic pool (90×50×50 cm) filled with water (30±1℃) to a depth of 40 cm.…”

Section: Methodsmentioning

confidence: 99%

Walnut extract exhibits anti-fatigue action via improvement of exercise tolerance in mice

Kim

2013

Lab Anim Res

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This study was conducted to investigate the anti-fatigue effect of walnut extract (WE) on forced swimming capacity in mice. Twenty-eight male ICR mice were randomly divided into four groups, a vehicle control (VC) or one of three WE administered groups (300, 600 and 900 mg/kg/day). WE was orally administered to mice once a day for 4 weeks, during which time a forced swimming test was conducted once a week. The vehicle control group was given a corresponding volume of sterile distilled water. After 4 weeks, the forced swimming capacity and levels of blood lactate, glucose, glutamine, ammonia and triacylglycerol, and liver glycogen were measured. In the WE administration group (600 and 900 mg/kg) the maximum swimming time increased significantly when compared with the vehicle control group. WE (600 and 900 mg/kg) significantly decreased the levels of lactate andammonia and increased the blood glutamine levels and liver glycogen content after forced swimming relative to the vehicle control group. The results of this study demonstrated the anti-fatigue effects of WE in a dose-dependent manner. The effects of WE at 600 and 900 mg/kg were similar. Overall, these results suggest that walnut has anti-fatigue activity and could elevate exercise tolerance.

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Section: Methodsmentioning

confidence: 99%

Walnut extract exhibits anti-fatigue action via improvement of exercise tolerance in mice

Kim

2013

Lab Anim Res

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“…The pressure influenced swimming evaluation were carried out twice per week by employing the previously described methods with some modifications (Ikarashi et al, 2013). In this study, the rats were neither subjected to any form of preliminary swim nor rest.…”

Section: Pressure Induced Swimming Investigationmentioning

confidence: 99%

Tetracarpidium Conophorum Extract Exhibits Anti-Fatigue Activity in Rats via Reduced Protein Catabolism, Increased Antioxidant Status and Delayed Lactate Elevation

Igbokwe¹,

Daniel

Adams³

et al. 2021

FJS

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Thirty rats of both sexes were assigned into 5 categories of six animals apiece. Animals in the unadministered (control) group were placed on distilled water. Group 1M and Group 1F animals were administered 500 mg/kg body weight (b.w) of T. conophorum aqueous nut extract whereas animals in Group 2M and Group 2F were administered 750 mg/kg dosage of the extricate (0.5 ml) orally once daily for 32 days. Phytoconstituents present in the extract include: saponins, flavonoids, tannins, phenols and alkaloids. The extract at 750mg/kg b.w notably (p<0.05) raised extracellular glucose in masculine rats when matched with males that received 500 mg/kg b.w. The 500 mg/kg dose of the extract appreciably (p<0.05) elevated BUN in both sexes, but with reduction in both groups at 750 mg/kg b.w when juxtaposed with their respective untreated animals. The extract at 500 mg/kg b.w increased LDH activity in male group when compared with male rats that received 750 mg/kg dose. The 750-extract dosage did not statistically (p>0.05) alter LDH activity in both sexes. The extract at 500 and 750mg/kg b.w increased the 3rd‒6th swim in male rats. Substantive (p<0.05) rise in swimming endurance time was first noticed at the 2nd swim when matched up with the control and group treated 500 mg/kg b.w, in female rats. Sequel to these research findings, it is hypothesized that the anti-weakness effect of T. conophorum might be adduced to delayed increase in lactate and reduction in protein catabolism

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“…Many existing ammonia-lowering agents including those that act on the hepatic urea cycle can be employed 224 , 225 . These could include salbutamol, conclevan, neomycin, sodium benzoate, ornithinephenyl acetate and L-ornithine aspartate 223 , 226 , 227 . Moreover, since impaired fast-twitch skeletal muscle glycolysis plays a role in ALS, improving muscle glycolysis through various existing drugs such as serotonin agonists and AMPK agonists (e.g.…”

Section: Biomarkers and Therapeuticsmentioning

confidence: 99%

A(a)LS: Ammonia-induced amyotrophic lateral sclerosis

Parekh

2015

F1000Res

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Amyotrophic lateral sclerosis (ALS) is a dreadful, devastating and incurable motor neuron disease. Aetiologically, it is a multigenic, multifactorial and multiorgan disease. Despite intense research, ALS pathology remains unexplained. Following extensive literature review, this paper posits a new integrative explanation. This framework proposes that ammonia neurotoxicity is a main player in ALS pathogenesis. According to this explanation, a combination of impaired ammonia removal— mainly because of impaired hepatic urea cycle dysfunction—and increased ammoniagenesis— mainly because of impaired glycolytic metabolism in fast twitch skeletal muscle—causes chronic hyperammonia in ALS. In the absence of neuroprotective calcium binding proteins (calbindin, calreticulin and parvalbumin), elevated ammonia—a neurotoxin—damages motor neurons. Ammonia-induced motor neuron damage occurs through multiple mechanisms such as macroautophagy-endolysosomal impairment, endoplasmic reticulum (ER) stress, CDK5 activation, oxidative/nitrosative stress, neuronal hyperexcitability and neuroinflammation. Furthermore, the regional pattern of calcium binding proteins’ loss, owing to either ER stress and/or impaired oxidative metabolism, determines clinical variability of ALS. Most importantly, this new framework can be generalised to explain other neurodegenerative disorders such as Huntington’s disease and Parkinsonism.

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Effect of Conclevan on Endurance Capacity in Mice

Cited by 7 publications

References 22 publications

Walnut extract exhibits anti-fatigue action via improvement of exercise tolerance in mice

Walnut extract exhibits anti-fatigue action via improvement of exercise tolerance in mice

Tetracarpidium Conophorum Extract Exhibits Anti-Fatigue Activity in Rats via Reduced Protein Catabolism, Increased Antioxidant Status and Delayed Lactate Elevation

A(a)LS: Ammonia-induced amyotrophic lateral sclerosis

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