“…because of the short half-life, affinity is not high, vomiting is difficult to fully control (Uygun et al, 2013;Wu et al, 2013;Xu et al, 2013;Yan et al, 2013;Yusuf et al, 2013;Wei et al, 2014). Hydrochloride palonosetron is an efficient, second generation of 5-HT3 receptor antagonist, with 5-HT3 receptor binding affinity of about 100 times stronger than ONDANSETRON (Ingersoll et al, 2010). Hydrochloride palonosetron is reported to have a long half-life plasma clearance, about 40 h (Ingersoll et al, DOI:http://dx.doi.org/10.7314/APJCP.2014.15.9…”