Reinforced concrete (RC) structures exhibit complex behaviour when subjected to fire. Severe thermal action evokes changes in the material microstructure and thermal-hydral-mechanical properties, depending on the heating rate, moisture, boundary conditions, geometry and size of the heated member, loading type, chemicalphysical interactions, etc. Extensive experimental material research has led to the development of mathematical models and numerical procedures that could, to a certain degree, capture adequately the behaviour of structures under fire conditions. Advanced modelling guidelines have been proposed in standards, such as Eurocode. Based on these recommendations and previous efforts conducted by other researchers, a numerical model is developed in finite element (FE) software ANSYS. The model incorporates temperature dependent physical, thermal and mechanical properties of constituting materials and conducts nonlinear heat transfer and structural analysis, simulating the response of RC frame structure under standard fire action. Explicit modelling of concrete and steel reinforcement allows monitoring of temperature evolution in both concrete and reinforcement elements, deformations, section forces and stresses and strains in reinforcement bars, providing a broad insight into the structural behaviour at both global and local level. Special consideration is given to the influence of fire scenario on RC frame behaviour.