Effect of Concurrent Training and Supplementation with &amp;#946;-Hydroxy- &amp;#946;-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation

Baptista, Danilo Bianchini; Dutra-de-Santana, Luis Felipe; Veras, Allice Santos Cruz; Alves-de-Menezes, Verônica; Santos, Nilton José dos; Papoti, Marcelo; Filho, José Carlos Silva Camargo; Teixeira, Giovana Rampazzo

doi:10.4067/s0717-95022018000100074

Cited by 4 publications

(3 citation statements)

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“…The aim of this study was to assess if repeated physical resistance training alters hormone and growth factor responses, and subsequently alters lipid metabolism pathways and apoptosis in the prostate. It is well established that exercise can change the metabolism and proportion of fatty acids in an organism, as originally shown by Pedersen & Febbraio [22], and resistance exercise can induce apoptosis in the rat prostate as we have previously shown [6,7]. However, the molecular mechanisms underlying these changes have yet to be described.…”

Section: Introductionmentioning

confidence: 78%

“…Previous studies conducted in our laboratory have shown that strength or resistance training affects the prostate by promoting hormonal changes and cell turnover [6][7][8]. Intense concentric and eccentric muscle concentrations during resistance training elevates circulating levels of anabolic/catabolic hormones (i.e., testosterone, testosterone free, growth hormone, insulin-like growth factor-1 (IGF-1), cortisol) and cytokines [9].…”

Section: Introductionmentioning

confidence: 99%

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Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

et al. 2020

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Background: Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Methods: Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Results: Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory elementbinding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. Conclusions: In this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer.

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Section: Introductionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

et al. 2020

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“…Physical exercise has already been shown to regulate the prostate environment. Data from our laboratory demonstrated that physical training in Wistar rats modulates the lipid and hormonal pro le of the ventral prostate 25,26 and improves body composition, expression of steroid hormone receptors, and cellular apoptosis in the prostate 27,28 . In animals fed with a high-fat diet (HFD) and submitted to strength training, reduced cell proliferation was observed as well as an increase in hormone receptors, modifying prostatic homeostasis 29 .…”

Section: Introductionmentioning

confidence: 97%

Physical Exercise Mitigates the Disturbs Caused in Ventral Prostate by High Fat Diet, Clarifying the Role of PPAR-Alpha

Tavares

Veras

Baptista

et al. 2021

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Body fat resulting from the consumption of fatty foods develops inflammation, a precursor to obesity, diabetes mellitus and prostatic diseases, causing tissue changes. On the other hand, aerobic physical exercise in conjunction with PPARα promotes an increase in energy expenditure, modulating cellular metabolism by altering prostate cell metabolism. This study aimed to elucidate the effect of the gene transcription factor PPARα as a prostatic regulator associated with the effects of aerobic physical exercise in mice fed to a high-fat diet. Wild Type and PPARα -/- mice (C57BL/6J) were fed a high-fat diet and submitted to aerobic physical training for 8 weeks. Prostates of male mice were analyzed histologically and metabolically for PIN progression. These findings suggest that the absence of PPARα reduces adiposity and but does not modify the expression AR and GR, up-regulate prostate inflammation, and suppresses Fas (CD95/Apo-1) increase in TNF-α, induced by prostatic lesions. On the other hand, aerobic physical exercise was effective in protecting prostatic damage induced by a high-fat diet, both in wild type and in PPARα-/- animals. The absence PPARα induces an inflammatory process and prostatic changes and associated with a high-fat diet, however, these inflammatory processes induce increased apoptosis and may further inhibit cell growth associated with physical exercise.

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Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice

Tavares

Veras

Thorpe

et al. 2022

Prostaglandins & Other Lipid Mediators

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Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation

Cited by 4 publications

References 13 publications

Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

Physical Exercise Mitigates the Disturbs Caused in Ventral Prostate by High Fat Diet, Clarifying the Role of PPAR-Alpha

Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice

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Effect of Concurrent Training and Supplementation with &#946;-Hydroxy- &#946;-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation

Cited by 4 publications

References 13 publications

Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

Physical Exercise Mitigates the Disturbs Caused in Ventral Prostate by High Fat Diet, Clarifying the Role of&nbsp;PPAR-Alpha

Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice

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Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation

Physical Exercise Mitigates the Disturbs Caused in Ventral Prostate by High Fat Diet, Clarifying the Role of PPAR-Alpha