Effect of conjugated equine estrogen in combination with two different progestogens on the risk factors of coronary heart disease in postmenopausal Chinese women in Taiwan: a randomized one-year study

Chang, Tong‐Bou; Lien, Yih-Ron; Chen, Ming; Cheng, Shao-Pei; Chen, Ruey-Jien; Chow, Song‐Nan

doi:10.1080/j.0001-6349.2004.00217.x

Cited by 7 publications

(3 citation statements)

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“…The changes in lipid/lipoproteins following therapy with CE/MPA in our study population are consistent with those found in Western women 47 and those reported for Chinese women in Taiwan 48 and Hong Kong 49 . These responses include lipid/lipoprotein changes that have traditionally been considered cardioprotective 50 , a conclusion that has been questioned after the publication of the Women's Health Initiative (WHI) study 51 and two secondary prevention studies 52,53 .…”

Section: Discussionsupporting

confidence: 92%

Distinct lipid/lipoprotein profiles and hormonal responsiveness in nine ethnic groups of postmenopausal Asian women: The Pan-Asia Menopause (PAM) study

et al. 2007

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The different lipid/lipoprotein profiles in the nine ethnic groups of postmenopausal Asian women evaluated here suggest a relationship to differences in the prevalence of cardiovascular disease reported for different regions in Asia. However, the reported prevalence data on cardiovascular disease morbidity and mortality in the regions corresponding to the nine ethnic groups are insufficient to allow qualitative comparisons with the lipid profiles shown in our study. The lipid/lipoprotein changes in response to estrogen/progestin therapy observed here are consistent with those reported for Western women.

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Section: Discussionsupporting

confidence: 92%

Distinct lipid/lipoprotein profiles and hormonal responsiveness in nine ethnic groups of postmenopausal Asian women: The Pan-Asia Menopause (PAM) study

et al. 2007

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“…LDL is one of the lipoproteins that promote endothelial damage, as well as reduction of high-density lipoprotein (HDL), a pleiotropic lipoprotein that prevents or alleviates endothelial damage (2). Studies have shown that estrogen replacement therapy and estrogen plus progestin replacement therapy alter these levels by decreasing LDL cholesterol levels and increasing HDL cholesterol levels (3,4). However, HDL cholesterol levels in women vary considerably in response to hormone replacement therapy (HRT) and a significant portion of the variability in HDL cholesterol levels can be attributed to genetic factors (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy

Nogueira-de-Souza¹,

Silva²,

Carvalho³

et al. 2009

Braz J Med Biol Res

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“…Estrogen exerts beneficial effects on blood lipids, lowdensity lipoprotein (LDL)/high-density lipoprotein (HDL) ratio, plasma triacylglycerol, and vascular function. [1][2][3][4] Recently, the cardiovascular benefits of hormone replacement therapy have been questioned, [5][6][7][8] and such therapy is no longer considered a viable option for reducing CVD in postmenopausal women. Therefore, other means of modulating cholesterol and reducing the risk of CVD in the absence of estrogen are desirable.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin E on Lipid Parameters in Ovariectomized Rats

Lucas

Chen

Chai

et al. 2006

Journal of Medicinal Food

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The risk of cardiovascular disease drastically increases at the onset of menopause, in part, because of rise in blood cholesterol and unfavorable changes in lipid profile. This study was designed to investigate the dose-dependent effects of vitamin E supplementation on lipid parameters in ovariectomized (ovx) rats. Sixty 12-month-old female Sprague-Dawley rats were either sham-operated (sham; one group) or ovx (four groups). All rats were maintained on a semipurified caseinbased diet (AIN-93M; 75 IU vitamin E/kg of diet) for a period of 120 days. Thereafter, ovx rats were placed on one of four doses of vitamin E treatment (75, 300, 525, or 750 IU vitamin E/kg of diet), while the sham group was continued on 75 IU vitamin E/kg of diet for 100 days. Ovariectomy tended to increase (by 24%, P = 0.1) serum non?high-density lipoprotein (HDL) cholesterol and decrease (by 14%, P = 0.1) HDL cholesterol. Vitamin E did not have any significant effects on serum lipid parameters. Liver total lipids were notably increased (P < .001) in ovx animals, and supplementation with vitamin E at 525 IU/kg of diet was able to significantly reduce liver total lipids by 13%. Additionally, ovariectomy caused an increase in serum glucose and liver C18:1 fatty acid concentrations along with decreases in C18:0, C20:4, and C22:6 fatty acid concentrations. These alterations on liver fatty acid profiles were unaffected by vitamin E. The findings of this study suggest that vitamin E supplementation moderately improves lipid parameters in ovarian hormone-deficient rats.

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Effect of conjugated equine estrogen in combination with two different progestogens on the risk factors of coronary heart disease in postmenopausal Chinese women in Taiwan: a randomized one-year study

Cited by 7 publications

References 0 publications

Distinct lipid/lipoprotein profiles and hormonal responsiveness in nine ethnic groups of postmenopausal Asian women: The Pan-Asia Menopause (PAM) study

Distinct lipid/lipoprotein profiles and hormonal responsiveness in nine ethnic groups of postmenopausal Asian women: The Pan-Asia Menopause (PAM) study

Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy

Effect of Vitamin E on Lipid Parameters in Ovariectomized Rats

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