Effect of Consumption Kemunings Leaf (Murraya Paniculata (L.) Jack) Infuse to Reduce Body Mass Index, Waist Circumference and Pelvis Circumference on Obese Patients

Sukohar, Asep; Busman, Hendri; Kurniawaty, Evi; Catur, M Marliando Satria Pangestu

doi:10.7897/2277-4343.08268

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…The moderate grade is the underweight category (17 %) and the lowest is the overweight category (5 %). The body mass index (BMI) is measured by assessing weight in kilograms and height in meters squared and then compare both of them (Sukohar et al, 2017).…”

Section: ) Menarche Distribution Of Respondentsmentioning

confidence: 99%

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Correlation Between Body Mass Index with Menstrual Cycle on Female Adolescent

Kumalasari

2018

ICOSHPRO

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Menstruation is the primary sexual sign that marks the period of puberty for women. Menstrual cycle disorders often occur in adolescents and are caused by several factors including psychological, hormonal, genetic disorders, organics abnormalities, and nutritional status. The nutritional situation is measured using a body mass index. The purpose of this study is to determine the correlation of body mass index and the menstrual cycle on the female adolescent. This research is an observational analytic study and uses a cross-sectional approach. The population of the study is all female students in Sunan Ampel State Islamic University. Accidental sampling technique is used in this study to obtain 36 respondent. Data collection from respondents was carried out by administering questionnaires and measurement of body weight and height. Data analysis uses the chi-square test. The result of the study is that most of body mass index (BMI) of respondents is standard (77,8%) and had regular menstrual cycles (75%). Chi-square test shows that there is a correlation between body mass index (BMI) and the length of the menstrual cycle (p=0,030).

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Section: ) Menarche Distribution Of Respondentsmentioning

confidence: 99%

“…Nutritional status can be assessed from the body mass index (BMI), which refers to a measure to predict percentage body fat through comparing the ratio of actual body weight and height (Sukohar et al, 2017). The hormone estrogen as a dominant factor of menstrual disturbances can be affected by body fat.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Body Mass Index with Menstrual Cycle on Female Adolescent

Kumalasari

2018

ICOSHPRO

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“…(Gautam et al, 2012). This plant is often used as an ornamental plant but actually has many properties such as anti-thyroid, skin smoothing, medicinal, antioxidant, antibacterial and antirheumatic (Sukohar et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Characterisation of Sheet Masks with the Addition of Kemuning Leaf Extract (Murraya paniculata L.)

Rahmadi,

Nasution,

Siregar

et al. 2023

edumaspuljr

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Research has been conducted on the use of kemuning leaves (murraya paniculate L.) in making sheet masks with formulations of kemuning leaf extract, chitosan, tapioca flour, and glycerin as facial smoothers. The results of the tensile strength test of sheet masks with preparations show that the tensile strength results of mask preparations without kemuning leaves are greater than the tensile strength using kemuning leaf extract and the results of the FTR test there is an absorption of wavenumber 3272.6 cm-1 -OH or –NH group, absorption at wavenumber 1640 cm-1 shows the presence of a C=O group meaning that in the process of making leaf sheet masks there is no chemical reaction, but only physical interaction. The results of the texture organoleptic test on the F5 sample are more dominantly preferred, the F0 sample is preferred in terms of color, and the F0 sample is preferred in terms of aroma, while in terms of general preference F0 is preferred by panelists. The pH test results on the six samples obtained pH results ranging from 6.12-6.29 categories are still safe to use marked by the pH value of cosmetic products allowed according to SNI ranging between 4.5-8.0. The antibacterial test results in the very strong category. The results of the antioxidant test are very strong and the results of measuring specific gravity show that the addition of kemuning leaf extract does not greatly affect the specific weight of a mask product. So that the use of kemuning leaves as a facial smoother is safe to use and has significant benefits.

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Unveiling the anti-obesity potential of Kemuning (Murraya paniculata): A network pharmacology approach

Fatriani,

Pratiwi,

Annisa

et al. 2024

PLoS ONE

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Obesity has become a global issue that affects the emergence of various chronic diseases such as diabetes mellitus, dysplasia, heart disorders, and cancer. In this study, an integration method was developed between the metabolite profile of the active compound of Murraya paniculata and the exploration of the targeting mechanism of adipose tissue using network pharmacology, molecular docking, molecular dynamics simulation, and in vitro tests. Network pharmacology results obtained with the skyline query technique using a block-nested loop (BNL) showed that histone acetyltransferase p300 (EP300), peroxisome proliferator-activated receptor gamma (PPARG), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) are potential targets for treating obesity. Enrichment analysis of these three proteins revealed their association with obesity, thermogenesis, energy metabolism, adipocytokines, fat cell differentiation, and glucose homeostasis. Metabolite profiling of M. paniculata leaves revealed sixteen active compounds, ten of which were selected for molecular docking based on drug-likeness and ADME results. Molecular docking results between PPARG and EP300 with the ten active compounds showed a binding affinity value of ≤ -5.0 kcal/mol in all dockings, indicating strong binding. The stability of the protein-ligand complex resulting from docking was examined using molecular dynamics simulations, and we observed the best average root mean square deviation (RMSD) of 0.99 Å for PPARG with trans-3-indoleacrylic acid, which was lower than with the native ligand BRL (2.02 Å). Furthermore, the RMSD was 2.70 Å for EP300 and the native ligand 99E, and the lowest RMSD with the ligand (1R,9S)-5-[(E)-2-(4-Chlorophenyl)vinyl]-11-(5-pyrimidinylcarbonyl)-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one was 3.33 Å. The in vitro tests to validate the potential of M. paniculata in treating obesity showed that there was a significant decrease in PPARG and EP300 gene expressions in 3T3-L1 mature adipocytes treated with M. paniculata ethanolic extract starting at concentrations 62.5 μg/ml and 15.625 μg/ml, respectively. These results indicate that M. paniculata can potentially treat obesity by disrupting adipocyte maturation and influencing intracellular lipid metabolism.

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Effect of Consumption Kemunings Leaf (Murraya Paniculata (L.) Jack) Infuse to Reduce Body Mass Index, Waist Circumference and Pelvis Circumference on Obese Patients

Cited by 5 publications

References 7 publications

Correlation Between Body Mass Index with Menstrual Cycle on Female Adolescent

Correlation Between Body Mass Index with Menstrual Cycle on Female Adolescent

Characterisation of Sheet Masks with the Addition of Kemuning Leaf Extract (Murraya paniculata L.)

Unveiling the anti-obesity potential of Kemuning (Murraya paniculata): A network pharmacology approach

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