Effect of Consumption of Animal Products on the Gut Microbiome
                    Composition and Gut Health

Lee, J H; Lee, Chaewon; Eor, Ju Young; Kwak, Mi Kyung; Huh, Chul Sung; Kim, Young-Hoon

doi:10.5851/kosfa.2023.e44

Cited by 11 publications

(2 citation statements)

References 113 publications

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“…The implications of this study go beyond just those of food decision making with HE, as SCFA such as butyrate is shown to maintain gut integrity and is protective against HE ( 39 ). Other studies have shown an association of high meat consumption with a decrease in SCFA producing gut bacteria such as Lachnospiraceae and Ruminococcaceae ( 40 ).…”

Section: Discussionmentioning

confidence: 96%

Substitution of One Meat-Based Meal With Vegetarian and Vegan Alternatives Generates Lower Ammonia and Alters Metabolites in Cirrhosis: A Randomized Clinical Trial

Badal,

Fagan,

Tate

et al. 2024

Clin Transl Gastroenterol

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Introduction: Diet can affect ammoniagenesis in cirrhosis and hepatic encephalopathy (HE) but the impact of dietary preferences on metabolomics in cirrhosis is unclear. As most Western populations follow meat-based diets, we aimed to determine the impact of substituting a single meat-based meal with an equal protein-containing vegan/vegetarian alternative on ammonia & metabolomics in outpatients with cirrhosis on a meat-based diet. Methods: Outpatients with cirrhosis with and without prior HE on a stable Western meat-based diet were randomized 1:1:1 into 3 groups. Patients were given a burger with 20g protein of either meat, vegan (V) or vegetarian (VG). Blood for metabolomics via liquid chromatography-mass spectrometry and ammonia was drawn at baseline and hourly for 3 hours post-meal while patients under observation. Stool microbiome characteristics, changes in ammonia, and metabolomics were compared between/within groups. Results: Stool microbiome composition was similar at baseline. Serum ammonia increased from baseline in the meat group but not the VG or V group. Metabolites of branched chain and acyl-carnitines decreased in the meat group compared to non-meat groups. Alterations in lipid profile (higher sphingomyelins and lower lysophospholipids) were noted in the meat group when compared to V and VG groups. Conclusions: Substitution of a single meat-based meal with a non-meat alternatives results in lower ammoniagenesis and altered serum metabolomics centered on branched-chain amino acids, acylcarnitines, lysophospholipids, and sphingomyelins in patients with cirrhosis regardless of HE or stool microbiome. Intermittent meat substitution with vegan or vegetarian alternatives could be helpful in reducing ammonia generation in cirrhosis.

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Section: Discussionmentioning

confidence: 96%

Substitution of One Meat-Based Meal With Vegetarian and Vegan Alternatives Generates Lower Ammonia and Alters Metabolites in Cirrhosis: A Randomized Clinical Trial

Badal,

Fagan,

Tate

et al. 2024

Clin Transl Gastroenterol

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“…The intestinal microbiota has long been recognized for its importance, particularly in the realm of veterinary medicine. These microorganisms colonize various anatomical sites of the animal host other than GI, such as the skin, mucosal surfaces (respiratory tract, urogenital tract), and internal organs, forming complex microbial communities known as microbiomes [2]. Early-life microbial succession in the gut of animals refers to the dynamic process by which diverse microbial communities, primarily bacteria, establish themselves in the gut of a newborn.…”

mentioning

confidence: 99%

The Profound Influence of Gut Microbiome and Extracellular Vesicles on Animal Health and Disease

Barathan,

Ng,

Lokanathan

et al. 2024

IJMS

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The animal gut microbiota, comprising a diverse array of microorganisms, plays a pivotal role in shaping host health and physiology. This review explores the intricate dynamics of the gut microbiome in animals, focusing on its composition, function, and impact on host–microbe interactions. The composition of the intestinal microbiota in animals is influenced by the host ecology, including factors such as temperature, pH, oxygen levels, and nutrient availability, as well as genetic makeup, diet, habitat, stressors, and husbandry practices. Dysbiosis can lead to various gastrointestinal and immune-related issues in animals, impacting overall health and productivity. Extracellular vesicles (EVs), particularly exosomes derived from gut microbiota, play a crucial role in intercellular communication, influencing host health by transporting bioactive molecules across barriers like the intestinal and brain barriers. Dysregulation of the gut–brain axis has implications for various disorders in animals, highlighting the potential role of microbiota-derived EVs in disease progression. Therapeutic approaches to modulate gut microbiota, such as probiotics, prebiotics, microbial transplants, and phage therapy, offer promising strategies for enhancing animal health and performance. Studies investigating the effects of phage therapy on gut microbiota composition have shown promising results, with potential implications for improving animal health and food safety in poultry production systems. Understanding the complex interactions between host ecology, gut microbiota, and EVs provides valuable insights into the mechanisms underlying host–microbe interactions and their impact on animal health and productivity. Further research in this field is essential for developing effective therapeutic interventions and management strategies to promote gut health and overall well-being in animals.

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The Emerging Role of the Microbiome in Carcinogenesis

Gates,

Dietz,

Martell

et al. 2024

Reference Module in Biomedical Sciences

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Effect of Consumption of Animal Products on the Gut Microbiome Composition and Gut Health

Cited by 11 publications

References 113 publications

Substitution of One Meat-Based Meal With Vegetarian and Vegan Alternatives Generates Lower Ammonia and Alters Metabolites in Cirrhosis: A Randomized Clinical Trial

Substitution of One Meat-Based Meal With Vegetarian and Vegan Alternatives Generates Lower Ammonia and Alters Metabolites in Cirrhosis: A Randomized Clinical Trial

The Profound Influence of Gut Microbiome and Extracellular Vesicles on Animal Health and Disease

The Emerging Role of the Microbiome in Carcinogenesis

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