Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial

Micka, Antje; Siepelmeyer, Anne; Holz, Anja; Theis, Stephan; Schön, Christiane

doi:10.1080/09637486.2016.1212819

Cited by 108 publications

(68 citation statements)

References 27 publications

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“…This is not to say that evidence of beneficial gastrointestinal effects of prebiotics is lacking. For example, the effects of the aforementioned chicory inulin on gut motility and sensation have been studied in man, albeit with variable results (Azpiroz et al, ; Slavin & Feirtag, ), and benefits in constipation described (Micka, Siepelmeyer, Holz, Theis, & Schön, ). Nevertheless, this effect on bowel transit formed the basis for the only health claim approved by the EFSA for a prebiotic.…”

Section: Prebioticsmentioning

confidence: 99%

Nutraceuticals as modulators of gut microbiota: Role in therapy

Quigley

2020

British J Pharmacology

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As our knowledge of the various roles of the gut microbiota in the maintenance of homeostasis grows and as we learn how a disrupted microbiota may contribute to disease, therapeutic strategies that target our microbial fellow‐travellers become ever more attractive. Most appealing are those interventions that seek to modify or supplement our diet through the addition of nutraceuticals. We now know that our diet, whether in the short or long term, is a major modifier of microbiota composition and function. Of the various nutraceuticals, two categories, prebiotics and probiotics, have received the greatest attention in basic research and product development. While our understanding of the impacts of prebiotics and probiotics on the indigenous microbiota and host biology have been described in great detail in vitro and in animal models, the clinical literature leaves much to be desired. While many claims have been made, few are supported by high quality clinical trials. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Prebioticsmentioning

confidence: 99%

Nutraceuticals as modulators of gut microbiota: Role in therapy

Quigley

2020

British J Pharmacology

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“…De acuerdo con los resultados de nuestro estudio, la bibliografía previa en población geriátrica muestra que la fibra es tan efectiva como la prescripción de laxantes para el manejo del estreñimiento 12,18 , se asocia a una reducción de la pauta de laxantes, cuando se combina con el tratamiento farmacológico 11 , y aumenta el confort del paciente 17 .…”

Section: Semana 1 N (%)unclassified

“…Por ello se desaconseja un tratamiento a largo plazo. Por otro lado, la bibliografía, aunque escasa, sugiere que una dieta enriquecida en fibra y con una elevada hidratación, no conlleva efectos adversos relevantes y tiene efectos beneficiosos en la función gastrointestinal en población adulta 12,13 . Hay poca bibliografía sobre la eficacia de las pautas dietéticas para reducir el estreñimiento en personas mayores.…”

Section: Introductionunclassified

Alternativa Eficaz al Tratamiento Farmacológico sobre el Estreñimiento en Ancianos Institucionalizados: Estudio Libera

Monge¹,

González²,

Jiménez³

et al. 2017

Rev Esp Nutr Hum Diet

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Introducción: El objetivo del presente estudio es conocer el impacto de la administración de un postre rico en fibra y sorbitol en la evolución de la pauta de laxantes en ancianos institucionalizados con estreñimiento. Material y Métodos:Estudio unicéntrico, intervencional, prospectivo, en ancianos con diagnósti-co de estreñimiento tratados con laxantes de una residencia geriátrica, en el que cada paciente es su propio comparador. Se administró un postre con alto contenido en fibra y sorbitol (Resource® Puré de Frutas rico en fibra), durante 7 semanas. La variable principal fue la diferencia de días de tratamiento farmacológico con laxantes entre la semana previa al inicio y la última semana del estudio.Resultados: Se estudiaron 40 pacientes. Mediana de edad de 88,5 años (rango: 72-101). Después de 7 semanas requirieron una media semanal de 3,5 días menos de tratamiento con laxantes. El número de pacientes con tratamiento farmacológico se redujo en un 40%. Las deposiciones semanales aumentaron en una media de 2. Disminuyeron las molestias gastrointestinales. La intervención no modificó la ingesta previa. La adherencia a la pauta prescrita fue superior al 94%. La reducción del nº de días con tratamiento laxante se asoció a: tomar 5 o más unidades del postre a la semana, ser mayor de 85 años, tener mala salud bucodental y no tener malnutrición ni trastornos de la dieta.Conclusiones: La administración de un postre rico en fibra y sorbitol puede constituir una alternativa efectiva y segura frente al tratamiento farmacológico con laxantes en población anciana con estreñimiento institucionalizada y podría ayudar a reducir la polimedicación en estos pacientes.

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“…In clinic, prebiotics have also been trialed for their benefits in various diseases [127][128][129][130][131]. Oligofructose (OFS), an inulin-type fructans, were added to diet for patients with NASH in a pilot randomized double-blind study [118].…”

Section: Gut Microbiota-targeted Therapy With Prebioticmentioning

confidence: 99%

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

Ma¹,

Zhou²,

Li³

2017

Preprint

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Gut microbiota play critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance, which highlighted the potential of gut microbiota-targeted therapies on these diseases. There are various ways that can manipulate gut microbiota including probiotics, prebiotics, synbiotics, antibiotics and some active components from herbal medicines. In this review, we first described the main roles of gut microbiota in mediating the development of NAFLD, and the advances in gut microbiota-targeted therapies in NAFLD in both the experimental and clinical studies, as well as the conclusions on the prospect of gut microbiotatargeted therapies in the future.

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Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial

Abstract: This trial was registered at clinicaltrials.gov as NCT02548247.

Cited by 108 publications

References 27 publications

Nutraceuticals as modulators of gut microbiota: Role in therapy

Nutraceuticals as modulators of gut microbiota: Role in therapy

Alternativa Eficaz al Tratamiento Farmacológico sobre el Estreñimiento en Ancianos Institucionalizados: Estudio Libera

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

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