Effect of consumption of red wine, spirits, and beer on serum homocysteine

Gaag, M.S. van der; Ubbink, Johan B.; Sillanaukee, Pekka; Nikkari, Seppo T.; Hendriks, H.

doi:10.1016/s0140-6736(00)02172-3

Cited by 142 publications

(82 citation statements)

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“…relationships between tHcy and smoking, physical activity and alcoholic beverages have been inconsistent (Wright et al, 1998;van der Gaag et al, 2000;Bleich et al, 2001;Stein et al, 2002;Tonstad and Urdal, 2002;Beulens et al, 2005). In contrast to clinical trials, the magnitude of the lifestyle changes observed in the current study was perhaps too small to produce a significant change in tHcy.…”

Section: Discussionmentioning

confidence: 54%

“…However, the effects of some of the lifestyle factors have been confirmed in randomized controlled trials (van der Gaag et al, 2000;Stein et al, 2002;Strandhagen et al, 2003), although not in all (Wright et al, 1998;Bleich et al, 2001;Tonstad and Urdal, 2002;Duncan et al, 2004;Beulens et al, 2005). Especially the results from trials examining the Simple regression models were adjusted for follow-up time, baseline values of homocysteine, and baseline value of the biological marker.…”

Section: Discussionmentioning

confidence: 99%

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Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

et al. 2005

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Background: Reduction in total homocysteine (tHcy) may be clinically relevant in the prevention of cardiovascular disease (CVD) in the general population. Objective: To examine the effects of changes in various lifestyle habits and lifestyle related biological CVD risk markers on changes in tHcy in relation to MTHFR(C677T) genotype. Design: A 1 year follow-up study. Setting: Copenhagen County, Denmark. Subjects: Statistical analyses were based on a population-based sample of 915 men and women aged 30-60 years assessed to be at increased CVD risk at baseline and therefore offered lifestyle intervention and re-examination after one year. Results: None of the studied lifestyle changes -smoking, physical activity, dietary habits, and coffee, tea, and alcohol consumption -was significantly associated with changes in tHcy, either overall, or in any of the MTHFR genotype subgroups. In addition, changes in tHcy did not differ between participants randomized to low-and high-intensity lifestyle intervention. However, the MTHFR TT genotype was associated with a significant decrease in tHcy compared with the CC/CT genotype in which an increase was observed. In addition, changes in tHcy were associated with changes in several of the biological CVD risk markers: weight, total cholesterol, HDL cholesterol, LDL cholesterol and systolic blood pressure. Conclusions: Our results indicate that tHcy may not be reduced by lifestyle changes; additionally, they suggest that tHcy may be related to biological CVD risk markers through a lifestyle independent pathway.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

et al. 2005

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“…The three micronutrients: folate, vitamin B 12 and vitamin B 6 have an important role in homocysteine metabolism (Selhub, 1999). However the effect of red wine on homocysteine concentrations appears to be independent of serum folate and vitamin B 12 concentrations and, as red wine contains neglegible vitamin B6 (van der Gaag et al, 2000), it is unlikely these micronutrients alone explain the effect. There may be other lifestyle or dietary factors (Fung et al, 2001) that differ with the choice of beverage.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it has been shown that long-term ingestion of large quantities of ethanol causes inhibition of methionine synthase activity due to its breakdown product acetaldehyde (Kenyon et al, 1998) and it has been proposed that elevated blood levels of ethanol, rather than nutritional factors are responsible for changes in homocysteine metabolism (Bleich et al, 2000c). With high alcohol intake beer, rich in folate and vitamin B 6 , may reduce the risks of raised homocysteine concentrations (Cravo et al, 1996;van der Gaag et al, 2000). Elevated homocysteine concentrations in chronic alcoholics predict the risk of fitting with alcohol withdrawal (Bleich et al, 2000a) and may be an important factor related to the increased risk of direct neuronal damage (Bleich et al, 2000b) or stroke (Hultberg et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…There is also good epidemiological evidence of the 'French Paradox', a reduction in cardiovascular morbidity and mortality in areas where wine is commonly consumed, despite a diet high in saturated fat (Renaud & Gueguen, 1998;Renaud et al, 1999). It has recently been proposed that the presence of folate and vitamin B 6 in beer may lead to a beverage-specific advantage through lowering of homocysteine concentration (van der Gaag et al, 2000). Current data indicate that very high alcohol consumption is associated with elevated homocysteine concentrations (Bleich et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Reduced plasma homocysteine in obese red wine consumers: a potential contributor to reduced cardiovascular risk status

Dixon

O'Brien

2002

Eur J Clin Nutr

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Background: Moderate alcohol consumption is associated with improved vascular risk profile and decreased mortality in the middle aged. An elevated homocysteine concentration is an independent risk factor for cardiovascular disease. Objective: To examine the relationship between alcohol consumption and homocysteine concentrations in severely obese patients (body mass index (BMI) > 35). Design: A careful alcohol history was obtained from 350 (male : female 1 : 5) consecutive patients as part of preoperative assessment for surgical treatment of obesity. Data were obtained concerning amount, frequency, timing and type of alcohol consumption. Fasting homocysteine, serum folate and vitamin B 12 concentrations were measured. Differences between groups were assessed using Student t-test, and ANOVA. Linear regression was used to assess factors influencing homocysteine concentration.Results: There is a U-shaped relationship between alcohol consumption and homocysteine concentrations, with light to moderate consumption being associated with lower concentrations. Those consuming < 100 g=week (n ¼ 165) of alcohol had geometric mean (95% CI of mean) serum homocysteine concentrations of 8.5 (8.2 -8.9) mmol=l compared with 9.5 (9.1 -9.9) mmol=l for non or rare consumers (n ¼ 153; P ¼ 0.001). The lower concentrations of homocysteine in regular consumers were associated with higher folate concentrations of 9.4 (8.6 -10.2) ng=ml when compared with non-consumers 7.5 (7.1 -7.8) ng=ml (P ¼ 0.001). Red wine consumers (n ¼ 42) had lower fasting concentrations of homocysteine 7.8 (7.5 -8.1) mmol=l compared with 153 non-consumers 9.4 (9.0 -9.8) mmol=l (P < 0.001), 82 beer and spirit consumers 9.0 (8.4 -9.7) mmol=l (P ¼ 0.005) and 73 white wine consumers 8.8 (8.2 -9.4) mmol=l (P ¼ 0.013). Red wine consumption was an independent predictor for lower homocysteine concentrations. Conclusion: Mild to moderate alcohol consumption, especially red wine consumption, in obese subjects is associated with lower fasting homocysteine concentrations. This may reduce cardiovascular risk and help explain the 'French paradox'.

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Extrapolation of Correlation Between 2 Variables in 4 General Medical Journals

Kuo

2002

JAMA

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Effect of consumption of red wine, spirits, and beer on serum homocysteine

Cited by 142 publications

References 5 publications

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

Reduced plasma homocysteine in obese red wine consumers: a potential contributor to reduced cardiovascular risk status

Extrapolation of Correlation Between 2 Variables in 4 General Medical Journals

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