Effect of Continuous 6 Months Oral Antioxidant Combination with Universally recommended Dosage in Idiopathic Male Infertility

Chattopadhyay, Ratna; Yasmin, Shanawaz; Chakravarty, B.

doi:10.5005/ijifm-7-1-iv

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…1 ) [ 12 13 14 15 ]. However, the outcomes of clinical trials included in the systematic reviews are not consistent, ranging from clear benefit to no clinical effect of the treatment, or even having significant detrimental effects [ 16 17 18 19 20 ]. The reasons for this inconsistency are multifactorial and include: small numbers of participants in the studies, variable treatment regimens, dosages, treatment duration, and the lack of placebo-controlled studies.…”

Section: Introductionmentioning

confidence: 99%

Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence

Agarwal

Leisegang

Majzoub

et al. 2021

World J Mens Health

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It is widely accepted that oxidative stress plays an important role in the pathophysiology of male infertility and that antioxidants could have a significant role in the treatment of male infertility. The main objectives of this study are: 1) to systematically review the current evidence for the utility of antioxidants in the treatment of male infertility; and 2) propose evidence-based clinical guidelines for the use of antioxidants in the treatment of male infertility. A systematic review of the available clinical evidence was performed, with articles published on Scopus being manually screened. Data extracted included the type of antioxidant used, the clinical conditions under investigation, the evaluation of semen parameters and reproductive outcomes. The adherence to the Cambridge Quality Checklist, Cochrane Risk of Bias for randomized controlled trials (RCTs), CONSORT guidelines and JADAD score were analyzed for each included study. Further, we provided a Strength Weakness Opportunity Threat (SWOT) analysis to analyze the current and future value of antioxidants in male infertility. Of the 1,978 articles identified, 97 articles were included in the study. Of these, 52 (53.6%) were uncontrolled (open label), 12 (12.4%) unblinded RCTs, and 33 (34.0%) blinded RCTs, whereas 44 (45.4%) articles tested individual antioxidants, 31 (32.0%) a combination of several products in variable dosages, and 22 (22.6%) registered antioxidant products. Based on the published evidence, we 1) critically examined the necessity of additional double-blind, randomized, placebo-controlled trials, and 2) proposed updated evidence-based clinical guidelines for antioxidant therapy in male infertility. The current systematic review on antioxidants and male infertility clearly shows that antioxidant supplementation improves semen parameters. In addition, it provides the indications for antioxidant treatment in specific clinical conditions, including varicocele, unexplained and idiopathic male infertility, as well as in cases of altered semen quality.

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Section: Introductionmentioning

confidence: 99%

Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence

Agarwal

Leisegang

Majzoub

et al. 2021

World J Mens Health

View full text Add to dashboard Cite

show abstract

“…These and numerous others are included in various registered AOX formulations [ 12 13 14 ] and food enriched with natural AOX [ 15 16 ]. Multiple studies have shown the benefit of AOX supplementation [ 17 18 19 ], and a recent Cochrane review found that oral AOX therapy may improve semen parameters and the likelihood of pregnancy [ 20 ]. However, the outcomes of clinical trials on the use of AOX in male infertility are not consistent, ranging from clear benefit [ 21 ] to no clinical effect [ 22 ], to even having significant detrimental effects [ 23 24 ].…”

Section: Introductionmentioning

confidence: 99%

A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility

Agarwal

Finelli

Selvam

et al. 2021

World J Mens Health

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Purpose The use of antioxidants is common practice in the management of infertile patients. However, there are no established guidelines by professional societies on antioxidant use for male infertility. Materials and Methods Using an online survey, this study aimed to evaluate the practice pattern of reproductive specialists to determine the clinical utility of oxidative stress (OS) testing and antioxidant prescriptions to treat male infertility. Results Responses from 1,327 participants representing 6 continents, showed the largest participant representation being from Asia (46.8%). The majority of participants were attending physicians (59.6%), with 61.3% having more than 10 years of experience in the field of male infertility. Approximately two-thirds of clinicians (65.7%) participated in this survey did not order any diagnostic tests for OS. Sperm DNA fragmentation was the most common infertility test beyond a semen analysis that was prescribed to study oxidative stress-related dysfunctions (53.4%). OS was mainly tested in the presence of lifestyle risk factors (24.6%) or sperm abnormalities (16.3%). Interestingly, antioxidants were prescribed by 85.6% of clinicians, for a duration of 3 (43.7%) or 3–6 months (38.6%). A large variety of antioxidants and dietary supplements were prescribed, and scientific evidence were mostly considered to be modest to support their clinical use. Results were not influenced by the physician's age, geographic origin, experience or training in male infertility. Conclusions This study is the largest online survey performed to date on this topic and demonstrates 1) a worldwide understanding of the importance of this therapeutic option, and 2) a widely prevalent use of antioxidants to treat male infertility. Finally, the necessity of evidence-based clinical practice guidelines from professional societies is highlighted.

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“…Filipcikova et al in their study included 44 infertile men who were supplemented with lycopene for 3 months and found that seminal plasma's AA/DHA ratio improved in these cases [23]. Another study done by Chattopadhyay et al in 2016 showed an increase in motility and sperm count with a lowering of reactive oxygen species level, which gives a positive effect of Co Q10 on the participating patients [24]. Supplementation of omega-3 reduced DNA fragmentation, improved total antioxidant capacity (TAC) concentrations, and enhanced sperm motility as per studies done by Juan Carlos Martinex Soto et al and Gonzalez Ravina et al respectively [25,26].…”

Section: Discussionmentioning

confidence: 97%

Role of Dietary Antioxidant Supplements in Male Infertility: A Review

Ghewade,

Vagha,

Ghewade

et al. 2024

Cureus

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Infertility, which affects around 70 million couples globally, is the inability to conceive after at least a year of continuous, unprotected sexual activity. Male-related elements are involving half of all infertility cases globally. Male infertility has various characteristics, including oligospermia, asthenozoospermia, and teratozoospermia. The purpose of this study was to assess the impact of antioxidant-rich food supplements on the properties of semen, like concentration of sperm, morphology, motility, fertility rate, and damage of DNA. Terms such as coenzyme Q10, antioxidants, folic acid, vitamin C, vitamin E, male infertility, selenium and others, were used to search for relevant research papers in the PubMed database. The findings of this study demonstrated beneficial improvements in semen parameters among infertile men who consumed dietary supplements, particularly combining antioxidants like coenzyme Q10, vitamin C, and vitamin E.

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Effect of Continuous 6 Months Oral Antioxidant Combination with Universally recommended Dosage in Idiopathic Male Infertility

Cited by 3 publications

References 8 publications

Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence

Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence

A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility

Role of Dietary Antioxidant Supplements in Male Infertility: A Review

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