Effect of Continuous Infusion of a Subhypnotic Dose of Propofol on Nausea and Vomiting after Carboprost Administration at Cesarean Delivery: A Randomized, Double-blind, Placebo-controlled Trial

Abstract

(Int J Gynecol Obstet. 2022;157:283–288) Postpartum hemorrhage (PPH) is one of the leading causes of maternal mortality. Carboprost is a 15-methyl F2a prostaglandin that induces uterine contractions and is recommended for PPH treatment. Carboprost has adverse side effects, the most prominent being nausea and vomiting. Propofol, when used at its subhypnotic dose, is known for reducing nausea and vomiting after chemotherapy treatment. This study aimed to show whether a steady administration of a subhypnotic dose of propofol prevents nausea and vomiting after carboprost is administered during cesarean delivery (CD).