Effect of Continuous Intravenous Calcium Loading on Fibroblast Growth Factor 23 in Normal and Uremic Rats

Shikida, Yasuto; Mizobuchi, Masahide; Inoue, Takashi; Hamada, Toma; Ogata, Hiroaki; Koiwa, Fumihiko; Shibata, Takanori

doi:10.1007/s00223-018-0440-2

Cited by 11 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dietary Ca 2+ stimulates FGF23 production , and a Ca 2+ deficit lowers FGF23 . Ca 2+ ‐dependent regulation of FGF23 seems to be independent of PTH/vitamin D and possibly be due to a direct effect on Fgf23 gene expression via calcium channels . Ca 2+ signalling is a major driver of FGF23 production: store‐operated Ca 2+ entry (SOCE) via calcium release‐activated calcium channel (CRAC) Orai1 enhances gene expression of Fgf23 .…”

Section: Homeostatic Regulation Of Fgf23mentioning

confidence: 99%

Regulation of fibroblast growth factor 23 (FGF23) in health and disease

et al. 2019

View full text Add to dashboard Cite

Fibroblast growth factor 23 (FGF23) is mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor αKlotho. FGF23 can exert several endocrine functions, such as inhibiting renal phosphate reabsorption and 1,25‐dihydroxyvitamin D3 production. Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes. Klotho and Fgf23 deficiencies result in pathologies otherwise encountered in age‐associated diseases, mainly as a result of hyperphosphataemia‐dependent calcification. FGF23 levels are also perturbed in the plasma of patients with several disorders, including kidney or cardiovascular diseases. Here, we review mechanisms controlling FGF23 production and discuss how FGF23 regulation is perturbed in disease.

show abstract

Section: Homeostatic Regulation Of Fgf23mentioning

confidence: 99%

Regulation of fibroblast growth factor 23 (FGF23) in health and disease

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Another potential explanation for the association between serum albumin-corrected calcium level and infection-related death may be calcium-induced increases in circulating FGF23 and calciprotein particles (CPPs). In previous experimental studies, calcium overload and ionized calcium were shown to up-regulate FGF23 synthesis and secretion in bone 26,27 . Notably, leukocyte recruitment, which is crucial in infections including sepsis, was prevented by FGF23 12 .…”

Section: Discussionmentioning

confidence: 91%

Increased Risk of Infection-Related and All-Cause Death in Hypercalcemic Patients Receiving Hemodialysis: The Q-Cohort Study

Yamada

Arase

Tokumoto

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Although hypercalcemia is a risk factor for all-cause mortality in hemodialysis patients, it remains unknown whether hypercalcemia increases the risk of infection-related death. A total of 2869 hemodialysis patients registered in the Q-cohort Study, a multicenter, prospective cohort study of hemodialysis patients, were analyzed. the predictor was albumin-corrected serum calcium level at baseline. the main outcome was infection-related death. Death risk were estimated by multivariableadjusted cox proportional hazard risk models and competing risk models. During the follow-up period of 4 years, 107 patients died of infection and 473 died of any cause. The patients were divided into four groups by the serum calcium level at baseline (G1, 5.7-8.9 mg/dL; G2, 9.0-9.4 mg/dL; G3, 9.5-9.9 mg/L; G4 10.0-16.5 mg/dL). In the multivariable-adjusted model, the incidence of infection-related death was significantly higher in the highest serum calcium group (G4) compared with the lowest serum calcium group (G1): hazard ratio [95% confidence interval], 2.34 [1.35-4.04], P = 0.002. Furthermore, higher serum calcium level was significantly associated with increased risk of all-cause death. In conclusion, our data suggest that a higher serum calcium level may be a risk factor for infection-related and all-cause death in hemodialysis patients.

show abstract

“… 20 , 21 , 22 , 23 , 24 , 25 , 26 Calcium metabolism is an important factor among the variety of potential factors that regulate FGF-23 synthesis and secretion. 27 However, serum FGF-23 levels did not change after dialysate calcium concentration conversion. Log serum FGF-23 level was not correlated with serum calcium levels, but it was associated with predialysis serum phosphate level and intradialytic phosphate elimination.…”

Section: Discussionmentioning

confidence: 92%

Short- and Long-term Effects of Dialysate Calcium Concentrations on Mineral and Bone Metabolism in Hemodialysis Patients: The K4 Study

Sakoh¹,

Taniguchi²,

Yamada³

et al. 2019

Kidney Medicine

View full text Add to dashboard Cite

Rationale & Objective The short- and long-term impact of conversion of dialysate calcium concentration from either 2.5 or 3.0 mEq/L to 2.75 mEq/L on mineral and bone metabolism remains unknown in hemodialysis patients. Study Design Nonrandomized intervention study. Setting & Population 12 hemodialysis patients treated at baseline with a 2.5-mEq/L dialysate calcium concentration and another 12 hemodialysis patients treated with a 3.0-mEq/L dialysate calcium concentration. Intervention Use of 2.75-mEq/L dialysate calcium concentration. Outcomes Changes in intradialytic calcium and phosphate clearance and changes in predialysis and intradialytic serum and ionized mineral and biochemical parameters over the 24 weeks following dialysate calcium conversion. Results Conversion of dialysate calcium concentration from 2.5 to 2.75 mEq/L increased intradialytic calcium loading and serum total and ionized calcium levels, whereas conversion of dialysate calcium from 3.0 to 2.75 mEq/L decreased intradialytic calcium loading and serum total and ionized calcium levels. Dialysate calcium concentration conversion did not affect intradialytic serum parathyroid hormone level, intradialytic phosphate elimination, or predialysis serum calcium, phosphate, parathyroid hormone, and fibroblast growth factor 23 levels. Intradialytic calcium influx was determined by dialysate calcium concentration and predialysis serum calcium levels, whereas intradialytic phosphate elimination was determined by predialysis serum phosphate levels. Limitations Small sample size and no control groups treated with 2.5- and 3.0-mEq/L dialysate calcium concentrations during the 24 weeks of the observation period. Conclusions Conversion of dialysate calcium concentration from either 3.0 or 2.5 to 2.75 mEq/L results in expected changes in calcium loading based on predialysis calcium concentration. The dialysate calcium concentration should be personalized based on clinical factors. Funding None. Trial Registration University Hospital Medical Information Network, www.umin.ac.jp/english/ , R000040105, UMIN000035184.

show abstract

Effect of Continuous Intravenous Calcium Loading on Fibroblast Growth Factor 23 in Normal and Uremic Rats

Cited by 11 publications

References 37 publications

Regulation of fibroblast growth factor 23 (FGF23) in health and disease

Regulation of fibroblast growth factor 23 (FGF23) in health and disease

Increased Risk of Infection-Related and All-Cause Death in Hypercalcemic Patients Receiving Hemodialysis: The Q-Cohort Study

Short- and Long-term Effects of Dialysate Calcium Concentrations on Mineral and Bone Metabolism in Hemodialysis Patients: The K4 Study

Contact Info

Product

Resources

About