Effect of Continuous Positive Airway Pressure (CPAP) on High-Sensitivity C-Reactive Protein levels (hs-CRP) in Patients with Obstructive Sleep Apnea (OSA)

Panjapornpon, Kanlaya; Sangsayunh, Piamlarp; Bangpattanasiri, Kittima; Jun-Kroot, Satreerat; Pumpothong, Watcharaporn; Pungtaway, Sunsanee; Tupwang, Arranee

doi:10.1183/1393003.congress-2017.pa2274

Cited by 1 publication

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“…We did not see a significant change in CRP levels after CPAP therapy during follow up. Our results are in agreement with those of recent larger RCTs that did not observe any modulation of CRP levels after CPAP therapy [36,[38][39][40]. In contrast with these findings, there are studies which demonstrated a beneficial effect of CPAP on inflammatory markers [41][42][43].…”

Section: Cpap and Markers Of Inflamationsupporting

confidence: 93%

“…Previous studies showed that inflammatory processes may be involved in the pathway between OSA and dyslipidemia [35,36]. To explore the influence of inflammatory mediators we chose CRP, which plays important roles in inflammatory processes, being a wellestablished marker of inflammation, shown to be elevated in cardiovascular events [37].…”

Section: Cpap and Markers Of Inflamationmentioning

confidence: 99%

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A Prospective Study of CPAP Therapy in Relation to Cardiovascular Outcome in a Cohort of Romanian Obstructive Sleep Apnea Patients

Chetan

Maierean

Gergely

et al. 2021

JPM

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Background: Despite efforts at treatment, obstructive sleep apnea (OSA) remains a major health problem, especially with increasing evidence showing an association with cardiovascular morbidity and mortality. The treatment of choice for OSA patients is Continuous Positive Airway Pressure (CPAP), which has been proven in randomized controlled trials to be an effective therapy for this condition. The impact of CPAP on the cardiovascular pathology associated with OSA remains, however, unclear. Although the effect of CPAP has been previously studied in relation to cardiovascular outcome, follow-up of the treatment impact on cardiovascular risk factors at one year of therapy is lacking in a Romanian population. Thus, we aimed to evaluate the one-year effect of CPAP therapy on lipid profile, inflammatory state, blood pressure and cardiac function, assessed by echocardiography, on a cohort of Romanian OSA patients. Methods: We enrolled 163 participants and recorded their baseline demographic and clinical characteristics with a follow-up after 12 months. Inflammatory and cardiovascular risk factors were assessed at baseline and follow up. Results: Our results show that CPAP therapy leads to attenuation of cardiovascular risk factors including echocardiographic parameters, while having no effect on inflammatory markers. Conclusion: Treatment of OSA with CPAP proved to have beneficial effects on some of the cardiovascular risk factors while others remained unchanged, raising new questions for research into the treatment and management of OSA patients.

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