Effect of controlled laser microporation on drug transport kinetics into and across the skin

Bachhav, Yogeshwar; Summer, Sandra N.; Heinrich, A.; Bragagna, T.; Böhler, Christof

doi:10.1016/j.jconrel.2010.05.025

Cited by 119 publications

(115 citation statements)

References 8 publications

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“…Various strategies including complex physical enhancement methods have been developed for effective transcutaneous delivery of micro-and nanoparticles, including artificial channels produced laser microporation [6][7][8][9]. Creating artificial channels by means of FLMA promotes deeper and better targeted delivery of particles in tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Creating artificial channels by means of FLMA promotes deeper and better targeted delivery of particles in tissue. By changing the parameters of laser beam, one can achieve different depths and shapes of the channels in skin [6][7][8][9][10][11], inducing e.g. pores with depth from 20 to 500 μm and diameters from 150 to 200 μm [6][7][8] or creating horizontal cuts with the depth from 150 to 300 μm [10] and channels with the depth up to 2 mm (to demonstrate the possibilities of the technique) [9].…”

Section: Introductionmentioning

confidence: 99%

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In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Genina

Svenskaya

Yanina

et al. 2016

Biomed. Opt. Express

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Abstract:We have developed a method for delivery of biocompatible CaCO 3 microcontainers (4.0 ± 0.8 µm) containing Fe 3 O 4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 μm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Genina

Svenskaya

Yanina

et al. 2016

Biomed. Opt. Express

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show abstract

“…This increase is not permanently proportional, because the maximal tissue concentration can be limited. 10,11,12 Clinically the density of the spots is closely related to the risk of complication and the optimization for proper amount of delivery is very important.…”

Section: Channel Numbersmentioning

confidence: 99%

Laser Assisted Drug and Cosmeceutical Delivery System of the Skin

Goo¹

2015

Medical Lasers

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Lasers have been used to enhance the delivery of topical agents. In laser assisted delivery, fractional technology is used in maintaining a main stream laser method. Targeting cutaneous lesions requires precise parameters for achievement of both efficacy and safety. Facilitating systemic absorption through the skin requires deeper penetration by lasers and the retention of the agents is also an important factor. Optimization with matching the agents and proper laser channels are another ongoing challenge. Key words

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“…® ) for minimally invasive drug delivery into and across the skin. [69,[87][88][89][90][91][92] The P. L.E.A.S.E. ® device applies short duration energy pulses (a few µs) at 2.94 µm that excite water molecules in the epidermis and result in their evaporation.…”

Section: Laser-assisted Microporation: a New Approach To Minimally Inmentioning

confidence: 99%

“…Experimental studies have been conducted into the delivery of small molecules (e.g. lidocaine, [89] prednisone [91] and diclofenac [93] ), peptides (e.g. exenatide [88] ) and proteins (e.g.…”

Section: Laser-assisted Microporation: a New Approach To Minimally Inmentioning

confidence: 99%

The Pharmaceutical Biochemistry Group: Where Pharmaceutical Chemistry Meets Biology and Drug Delivery

Perozzo¹,

Scapozza²

2012

Chimia

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Successful drug discovery and development of new therapeutics is a long, expensive multidisciplinary process needing innovation and the integration of smart cutting edge science and technology to overcome the challenges in taking a drug from the bench to the bedside. The research activities of the Pharmaceutical Biochemistry group span the drug discovery and development process, providing an interface that brings together pharmaceutical chemistry, biochemistry, structural biology, computational chemistry and biopharmaceutics. Formulation and drug delivery are brought into play at an earlier stage when facing the perennial challenge of transforming a potent molecule in vitro into a therapeutic agent in vivo. Concomitantly, drug delivery results can be understood at a molecular level. This broad range of interdisciplinary research activities and competences enables us to address key challenges in modern drug discovery and development, provides a powerful collaborative platform for other universities and the pharmaceutical industry and an excellent training platform for pharmacists and pharmaceutical scientists who will later be involved in drug discovery and development.

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Effect of controlled laser microporation on drug transport kinetics into and across the skin

Cited by 119 publications

References 8 publications

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Laser Assisted Drug and Cosmeceutical Delivery System of the Skin

The Pharmaceutical Biochemistry Group: Where Pharmaceutical Chemistry Meets Biology and Drug Delivery

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