Effect of copaiba oil on acute pancreatitis in mice

Medeiros, Daniel L.; Luiz, Holanda Filho; Montenegro, Tarciso B. S.; Camara, Paula R. S.

doi:10.5455/jeim.230114.or.095

Cited by 2 publications

(6 citation statements)

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“…Leukocyte migration to the sites of inflammation occurs through specific interactions with the vascular endothelium under conditions of shear stress [73]. Previously our team demonstrated the capacity of copaiba oil treatment to reduce leukocyte migration and edema in caerulein-induced pancreatitis in mice [13].…”

Section: Discussionmentioning

confidence: 98%

“…Mice or rats were pretreated orally with copaiba oil (2 ml/kg) or vehicle (0.9% NaCl) 2 h before induction of acute visceral pain and other anti-nociceptive activity models, and with dipyrone (500 μg/Kg, oral) or morphine (5 mg/kg, intra-peritoneal) 0.5 h before the tests [13,43] To examine acid-evoked pain responses, we used the "AAinduced writhing test." Writhing was induced by intraperitoneal injection (100 μl) of AA 0.6% [44].…”

Section: Drug Pre-treatment and Behavioral Testingmentioning

confidence: 99%

“…Copaifera officinalis was the first species in the genus Copaifera to be described [6][7][8]. Many studies using experimental pharmacological models have established the anti-inflammatory, gastroprotective, wound healing and others activities of copaiba oil [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Study of copaiba oil on behavioral testing in rodent models by inducing neuropathic and inflammatory pain

Medeiros¹,

Araujo²,

Montenegro³

et al. 2014

J Exp Integr Med

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Objective: The Copaiba sp. oil has been known to possess anti-inflammatory, antiulcer, antiviral and others activities. The copaiba oil pharmacological activity was assessed using models of nociception in mice. The involvement of both megakaryocytes and enzyme markers for muscle damage under acute copaiba oil treatment on acetic acid (AA)-induced abdominal constriction was investigated. Materials and Methods: Swiss mice and/or Wistar rats were pretreated orally (2 h) before all experimental procedure with Copaifera officinalis oil or vehicle. The abdominal constriction response was induced by intra-peritoneal injection of AA 0.6% and the number of abdominal constrictions was counted cumulatively over 60 min. Behavioral nociception models, i.e., hot plate and tail-flick test, were also performed. Plasma enzymes (creatine kinase [CK]; aspartate aminotransferases [AST] and alanine aminotransferases; [ALT]) and organs histology were analyzed too. Results: Cop aiba oil administration caused a significant reduction on the AA-induced writhing in the rodents. It also presented significant antinociceptive activity in the behavioral models. Plasma CK levels and megakaryocyte production were significantly augmented in the copaiba oil-pretreated animals when compared with control group. AST and ALT remained unchanged. Conclusion: Our results indicate that copaiba oil may act as an anti-nociceptive agent and induce plasmatic CK increase by a mechanism involving probably the splenic overproduction of megakaryocytes, suggesting this way the participation of immature platelets in the process.

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Section: Discussionmentioning

confidence: 98%

Section: Drug Pre-treatment and Behavioral Testingmentioning

confidence: 99%

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Study of copaiba oil on behavioral testing in rodent models by inducing neuropathic and inflammatory pain

Medeiros¹,

Araujo²,

Montenegro³

et al. 2014

J Exp Integr Med

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“…Apart from leishmaniasis, copaiba oil is also reported to show anti‐fungal like activity. Like other available phytoconstituents, copaiba oil also targets inflammatory signaling in pancreatitis and significantly improved the levels of pancreatic amylase, suppressed neutrophil infiltration and decreased oxidative stress (Medeiros et al , ). Despite its activity in pancreatitis, there is still very stagnant research being undertaken on this plant oil.…”

Section: Herbal Remedies Used For Treating Pancreatitismentioning

confidence: 99%

“…Rigorous animal experiments are still going on to evaluate its therapeutic effects in different areas of research. Diosmetin mainly targets cell cycle to show anti‐proliferative effects (Medeiros et al , ). Diosmetin was reported to act by inhibiting NF‐κB pathway in cerulein‐induced pancreatitis where it showed impressive suppression of cytokine (IL‐1β, IL‐6 and TNF‐α) release along with improvement of amylase and lipase levels.…”

Section: Herbal Remedies Used For Treating Pancreatitismentioning

confidence: 99%

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

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Effect of copaiba oil on acute pancreatitis in mice

Cited by 2 publications

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Study of copaiba oil on behavioral testing in rodent models by inducing neuropathic and inflammatory pain

Study of copaiba oil on behavioral testing in rodent models by inducing neuropathic and inflammatory pain

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

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