Effect of copper- and zinc-methionine supplementation on bioavailability, mineral status and tissue concentrations of copper and zinc in ewes

Pal, D. K.; Gowda, N. K. S.; Prasad, C. S.; Amarnath, Rathna P.; Bharadwaj, U.; Babu, G. Suresh; Sampath, K. T.

doi:10.1016/j.jtemb.2009.11.007

Cited by 58 publications

(40 citation statements)

References 21 publications

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“…Our observation of significantly higher copper concentrations in the plasma than those in tissues except liver is consistent with the values reported for the rainbow trout (Apines-Amar et al 2003;Pal et al 2010). This is probably due to copper being associated with the oxygen-carrying protein, haemocyanin, which exists in the haemolymph, and that more vacuolated hepatopancreas has higher Cu concentration (Wang et al 2009).…”

supporting

confidence: 92%

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Effects of dietary inorganic copper on growth performance and immune responses of juvenile beluga,Huso huso

2014

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A 12‐week feeding trial was conducted to evaluate the optimum dietary inorganic copper (copper sulphate) in juvenile beluga, Huso huso. Eight semi‐purified diets containing 1.1 (Cu1.0), 3.5 (Cu4.0), 7.1 (Cu7.0), 9.7 (Cu10), 13.1 (Cu13), 25.1 (Cu25), 49.9 (Cu50) and 195 (Cu195) mg Cu kg−1 diet in the form of CuSO4.5H2O were fed to fish of initial body weight 8.49 ± 0.32 g and length 11.85 ± 0.66 cm (mean ± SD) in triplicate groups in a flow‐through system. Weight gain (WG) of fish fed Cu10 and Cu13 diets was significantly higher than that of fish fed Cu1.0, Cu4.0, Cu25, Cu50 and Cu195 diets (P < 0.05). Whole‐body and muscle crude protein increased with dietary Cu up to the supplementation level of 13.1 mg kg−1 diet and then decreased. Whole‐body lipid content was negatively correlated, while whole‐body ash was positively correlated with dietary copper concentration. Hepatic copper–zinc superoxide dismutase activity of fish fed Cu10 and Cu13 diets was significantly higher than that of fish fed Cu1.0, Cu4.0 and Cu195 diets. Hepatic thiobarbituric acid‐reactive substances of fish fed Cu13 diet was significantly lower than those of fish fed the other diets except for that of fish fed Cu10 diet. Aspartate aminotransferase, alanine aminotransferase and copper accumulation in tissues increased with dietary copper. Broken‐line analysis of WG suggested that the optimum dietary Cu level was 10.3 mg Cu kg−1 diet. Therefore, these results may indicate that the optimum dietary Cu levels could be greater than 10.3 mg Cu kg−1 diet but less than 13.1 mg Cu kg−1 diet in juvenile beluga, when copper sulphate is used as the dietary source of inorganic copper.

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supporting

confidence: 92%

“…; Pal et al . ). This is probably due to copper being associated with the oxygen‐carrying protein, haemocyanin, which exists in the haemolymph, and that more vacuolated hepatopancreas has higher Cu concentration (Wang et al .…”

Section: Discussionmentioning

confidence: 97%

Effects of dietary inorganic copper on growth performance and immune responses of juvenile beluga,Huso huso

2014

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“…Neither study found any differences in tissue deposition between the sources. Similarly, no difference in muscle copper concentrations in ewes was found when copper was given in the form of sulphate or chelated amino acid hydrate (Pal et al, 2010). The overall equivalent bioavailability of copper from both sources in terms of copper deposition is also supported by data from the tibia in chickens for fattening (Bao et al, 2007;Jegede et al, 2011).…”

Section: Copper Deposition In Tissues and Products Of Animal Originmentioning

confidence: 88%

Scientific Opinion on the safety and efficacy of copper compounds (E4) as feed additives for all species: cupric chelate of amino acids hydrate, based on a dossier submitted by Zinpro Animal Nutrition Inc.

Feed¹

2013

EFS2

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Cupric chelate of amino acids hydrate is safe for all animal species/categories up to the authorised maximum of total copper content in complete feed. Consumption surveys include copper from foodstuffs of animal origin. Since the supplementation of animal feed with copper‐containing compounds has not essentially changed over the last decade, no change in the contribution of foodstuffs originating from supplemented animals to the overall copper intake of consumers is expected. No concerns for consumer safety are expected from the use of cupric chelate of amino acids hydrate in animal nutrition, which would substitute for other copper sources. The additive should be considered as a skin and eye irritant and, owing to its amino acid/peptide component, as a skin/respiratory sensitiser. Potential risks to soil organisms have been identified as a result of the application of piglet manure. Levels of copper in other types of manure are too low to create a potential risk within the timescale considered. There might also be a potential environmental concern related to the contamination of sediment resulting from drainage and the run‐off of copper to surface water. In order to draw a final conclusion, further model validation is needed and some further refinement to the assessment of copper‐based feed additives in livestock needs to be considered, for which additional data would be required. The use of copper‐containing additives in aquaculture up to the authorised maximum of total copper content in complete feeds is not expected to pose an appreciable risk to the environment. The extent to which copper‐resistant bacteria contribute to the overall antibiotic resistance situation cannot be quantified at present. Cupric chelate of amino acids hydrate is recognised as an efficacious source of copper to meet animal requirements.

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“…Several studies have shown the effects of diet Zn and Cu or their deficiencies on antioxidant enzymes, including SOD [21][22][23][24][25] . Pal et al [22] investigated the effect of supplementing Cu-and Zn-methionine sources on plasma and tissue Cu/Zn levels, and SOD. They suggested that Cu/Zn-SOD can be used as a marker for evaluating the status of Cu and Zn.…”

Section: Discussionmentioning

confidence: 99%

“…Rahman et al [24] , showed that 100 mg/buck/ day Zn sulphate could improve semen traits and plasma antioxidant capacity [23] . Al-Bayati et al [23] , evaluated the cardiovascular effects of Cu deficiency on the activity of SOD in 55 patients with diabetes with and without diabetic nephropathy [22] . They revealed that the regulation of Cu concentrations can be considered a target for treatment of diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Reduced Serum Levels of Zinc and Superoxide Dismutase in Obese Individuals

et al. 2016

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The oxidant-stress (OS) has an essential role to play in the pathogenesis and progression of many diseases. OS is the outcome when the level of free-radical-formation is increased or protective-antioxidant-mechanisms are compromised. Its value is expected to increase, although its emerging roles have not been conclusive in different studies. The objective of this study was to explore the level of zinc, copper, and antioxidant in response to obesity-related-stress by measuring superoxide-dismutase (SOD) levels as a key antioxidant-enzyme in 706 individuals with/without obesity. Anthropometric/biochemical parameters including total-cholesterol (TC), fasting-blood-glucose, high-density-lipoprotein (HDL), low-density-lipoprotein, and triglycerides were determined. The activity of SOD was measured followed by the measurement of Cu and Zn levels. Obese subjects had a significantly higher level of body mass index (BMI) and TC, while the level of HDL was lower in the obese group, as compared to the related values in control subjects. The level of Zn was significantly decreased in the obese group, while the level of Cu and Cu/Zn ratio increased. Additionally, we observed that the SOD level was less in obese subjects when compared to that in the non-obese subjects. In addition to the complications of high BMI, low level of Zn and SOD in obesity can be considered a risk factor, resulting in a reduced antioxidant response, supporting the need for identifying a suitable treatment option for this group.

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Effect of copper- and zinc-methionine supplementation on bioavailability, mineral status and tissue concentrations of copper and zinc in ewes

Cited by 58 publications

References 21 publications

Effects of dietary inorganic copper on growth performance and immune responses of juvenile beluga,Huso huso

Effects of dietary inorganic copper on growth performance and immune responses of juvenile beluga,Huso huso

Scientific Opinion on the safety and efficacy of copper compounds (E4) as feed additives for all species: cupric chelate of amino acids hydrate, based on a dossier submitted by Zinpro Animal Nutrition Inc.

Reduced Serum Levels of Zinc and Superoxide Dismutase in Obese Individuals

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