Effect of Copper Sulphate and Cadmium Chloride on Non-Human Primate Sperm Function In Vitro

Hardneck, Farren; Villiers, Charon de; Maree, Liana

doi:10.3390/ijerph18126200

Cited by 5 publications

(3 citation statements)

References 83 publications

(91 reference statements)

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“…Even despite lower concentrations of Cu in SP, all authors mention the adverse effect on spermatozoa cells including decreased motility and viability and higher incidence of disrupted acrosomes. The disturbing effect of Cu was also proven in in vitro conditions [ 43 , 44 , 45 ]. Concerning redox homeostasis of sperm cells, we analyzed nonenzymatic parameters as well as enzymatic parameters including GPx and SOD.…”

Section: Discussionmentioning

confidence: 99%

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

et al. 2022

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This study monitored the chemical and biochemical composition of bovine seminal plasma (SP). Freshly ejaculated semen (n = 20) was aliquoted into two parts. The first aliquot was immediately assessed to determine the sperm motion parameters. Another motility measurement was performed following an hour-long co-incubation of spermatozoa with SP at 6 °C. The other aliquot was processed to obtain the SP. Seminal plasma underwent the analyses of chemical composition and quantification of selected proteins, lipids and RedOx markers. Determined concentrations of observed parameters served as input data to correlation analyses where associations between micro and macro elements and RedOx markers were observed. Significant correlations of total oxidant status were found with the content of Cu and Mg. Further significant correlations of glutathione peroxidase were detected in relation to Fe and Hg. Furthermore, associations of chemical elements and RedOx markers and spermatozoa quality parameters were monitored. The most notable correlations indicate beneficial effects of seminal Fe on motility and Mg on velocity and viability of spermatozoa. On the contrary, negative correlations were registered between Zn and sperm velocity and seminal cholesterol content and motility. Our findings imply that seminal plasma has a prospective to be developed as the potential biomarker of bull reproductive health.

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Section: Discussionmentioning

confidence: 99%

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

et al. 2022

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“…Results showed a decrease in testes and epididymis weight and a significant increase in sperm abnormalities. Long-term, high-dose Cu 2+ exposure was found to be negatively correlated with sperm motility, viability and vitality, acrosome intactness, and hyperactivation in a study performed on the vervet monkey ( Chlorocebus aethiops ), the chacma baboon ( Papio ursinus ), and the rhesus monkey ( Macaca mulatta ) used as models for reproductive studies [ 137 ].…”

Section: Male Reproductive Toxicity Of Micronutrient Metalsmentioning

confidence: 99%

An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility

Maciejewski

Radzikowska-Büchner²,

Flieger

et al. 2022

IJERPH

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Numerous factors affect reproduction, including stress, diet, obesity, the use of stimulants, or exposure to toxins, along with heavy elements (lead, silver, cadmium, uranium, vanadium, mercury, arsenic). Metals, like other xenotoxins, can cause infertility through, e.g., impairment of endocrine function and gametogenesis or excess production of reactive oxygen species (ROS). The advancement of nanotechnology has created another hazard to human safety through exposure to metals in the form of nanomaterials (NMs). Nanoparticles (NPs) exhibit a specific ability to penetrate cell membranes and biological barriers in the human body. These ultra-fine particles (<100 nm) can enter the human body through the respiratory tract, food, skin, injection, or implantation. Once absorbed, NPs are transported to various organs through the blood or lymph. Absorbed NPs, thanks to ultrahigh reactivity compared to bulk materials in microscale size, disrupt the homeostasis of the body as a result of interaction with biological molecules such as DNA, lipids, and proteins; interfering with the functioning of cells, organs, and physiological systems; and leading to severe pathological dysfunctions. Over the past decades, much research has been performed on the reproductive effects of essential trace elements. The research hypothesis that disturbances in the metabolism of trace elements are one of the many causes of infertility has been unquestionably confirmed. This review examines the complex reproductive risks for men regarding the exposure to potentially harmless xenobiotics based on a series of 298 articles over the past 30 years. The research was conducted using PubMed, Web of Science, and Scopus databases searching for papers devoted to in vivo and in vitro studies related to the influence of essential elements (iron, selenium, manganese, cobalt, zinc, copper, and molybdenum) and widely used metallic NPs on male reproduction potential.

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“…Cadmium and copper are two heavy metals that may adversely affect the reproductive health of humans, especially male fecundity, after exposure [16]. It was shown that Cu 2+ immobilization in metakaolin-based geopolymer consists of chemical incorporation into the geopolymer matrix and was pH dependent as a large amount of Cu 2+ was precipitated in the form of gerhardtite (low pH) or tenorite and spertiniite (high pH) [17].…”

Section: Introductionmentioning

confidence: 99%

Effective Stabilization of Cadmium and Copper in Iron-Rich Laterite-Based Geopolymers and Influence on Physical Properties

Nkwaju,

Nouping,

Bachirou

et al. 2023

Materials

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This study aimed to investigate the efficiency of a geopolymer binder of the type of Na-poly(ferro–silico–aluminate) as a matrix for the stabilization of heavy metals along with their effect on the development of structural performances. The artificial contamination of soil with ions was carried out and used to prepare an alkali-activated iron-rich lateritic soil binder. Further, various microstructural analyses were carried out to explain the stabilization mechanism. The stabilization efficiency was assessed by leaching tests in de-ionized water and hydrochloric acid (0.1 M, HCl). Then, the physical properties were determined to evaluate the impact of heavy metals on the structural performance of the binder. Results demonstrated that the prepared geopolymer binder has the lowest stabilization capacity in an acidic medium (low pH) than in water with high pH. However, the stabilization of Cu ions was effective at 99%, while the Cd ion is barely retained in the matrix. Firstly, the mechanism consists of chemical bonds through ion exchange with sodium of the Na-poly(ferro–silico–aluminate) network. Secondly, through physical interaction with the pore network of the matrix, the heavy metals induced structural deterioration in the geopolymer matrix with a decrease in the compressive strength and bulk density and an increase of both apparent porosity and water absorption.

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Effect of Copper Sulphate and Cadmium Chloride on Non-Human Primate Sperm Function In Vitro

Cited by 5 publications

References 83 publications

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility

Effective Stabilization of Cadmium and Copper in Iron-Rich Laterite-Based Geopolymers and Influence on Physical Properties

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