Effect of Copper, Zinc, and Selenium on the Formation of Bovine Neutrophil Extracellular Traps

Zhou, Xiechen; Wang, Hai; Lian, Shuai; Wang, Jianfa; Wu, Rui

doi:10.1007/s12011-020-02477-1

Cited by 10 publications

(4 citation statements)

References 31 publications

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“…Studies have shown that zinc finger protein 36 (Tristetraprolin, TTP) plays an important role in regulating the inflammatory response, and when Cu concentration increases, some of the Cu is induced to bind to TTP, which prevents TTP from inhibiting the inflammatory response, resulting in increased inflammation levels [ 46 ]. Animal experiments have shown that the addition of metals such as Cu to the diet enhances the immunity of dairy cows in the pre-and post-partum period and increases the percentage of neutrophils by promoting neutrophil–endothelial interactions, which reduces the mobility of polymorphonuclear neutrophils and causes them to adhere to the endothelium [ 47 , 48 ]. The above studies have also demonstrated that changes in copper levels in vivo can significantly affect changes in the levels of single inflammatory cells.…”

Section: Discussionmentioning

confidence: 99%

Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population

Zhao,

Wei,

Liu

et al. 2024

BMC Public Health

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Background Exposure to heavy metals alone or in combination can promote systemic inflammation. The aim of this study was to investigate potential associations between multiple plasma heavy metals and markers of systemic immune inflammation. Methods Using a cross-sectional study, routine blood tests were performed on 3355 participants in Guangxi, China. Eight heavy metal elements in plasma were determined by inductively coupled plasma mass spectrometry. Immunoinflammatory markers were calculated based on peripheral blood WBC and its subtype counts. A generalised linear regression model was used to analyse the association of each metal with the immunoinflammatory markers, and the association of the metal mixtures with the immunoinflammatory markers was further assessed using weighted quantile sum (WQS) regression. Results In the single-metal model, plasma metal Fe (log10) was significantly negatively correlated with the levels of immune-inflammatory markers SII, NLR and PLR, and plasma metal Cu (log10) was significantly positively correlated with the levels of immune-inflammatory markers SII and PLR. In addition, plasma metal Mn (log10 conversion) was positively correlated with the levels of immune inflammatory markers NLR and PLR. The above associations remained after multiple corrections. In the mixed-metal model, after WQS regression analysis, plasma metal Cu was found to have the greatest weight in the positive effects of metal mixtures on SII and PLR, while plasma metals Mn and Fe had the greatest weight in the positive effects of metal mixtures on NLR and LMR, respectively. In addition, blood Fe had the greatest weight in the negative effects of the metal mixtures for SII, PLR and NLR. Conclusion Plasma metals Cu and Mn were positively correlated with immunoinflammatory markers SII, NLR and PLR. While plasma metal Fe was negatively correlated with immunoinflammatory markers SII, NLR, and PLR.

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Section: Discussionmentioning

confidence: 99%

Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population

Zhao,

Wei,

Liu

et al. 2024

BMC Public Health

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“…In this study, low Se concentration (0.01 mg/L) promoted NET formation, while other Se concentrations (0.08 mg/L and 2.0 mg/L) did not affect NET formation compared to PBS. The authors suggested that cow immunity can be improved by adding various micronutrients during cow insemination [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…There have only been a few research papers on the specific role of selenoproteins in the functioning of neutrophils. These studies have an episodic character and are usually associated with the investigation of additional consumption of Se in animal farming in order to enhance animal resistance to diseases [ 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Modulation of the Functional State of Mouse Neutrophils by Selenium Nanoparticles In Vivo

Mal’tseva

Gudkov

Turovsky

2022

IJMS

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This study aimed to discover the immunomodulatory effect of selenium nanoparticles (SeNPs) on the functional state of neutrophils in vivo. Intraperitoneal injections of SeNPs (size 100 nm) 2.5 mg/kg/daily to BALB/c mice for a duration of 7–28 days led to the development of an inflammatory reaction, which was registered by a significant increase in the number of neutrophils released from the peritoneal cavity, as well as their activated state, without additional effects. At the same time, subcutaneous injections of the same SeNPs preparations at concentrations of 0.1, 0.5, and 2.5 mg/kg, on the contrary, modulated the functional state of neutrophils depending on the concentration and duration of SeNPs administration. With the use of fluorescence spectroscopy, chemiluminescence, biochemical methods, and PCR analysis, it was found that subcutaneous administration of SeNPs (0.1, 0.5, and 2.5 mg/kg) to mice for a short period of time (7–14 days) leads to modification of important neutrophil functions (adhesion, the number of migrating cells into the peritoneal cell cavity, ROS production, and NET formation). The obtained results indicated the immunostimulatory and antioxidant effects of SeNPs in vivo during short-term administration, while the most pronounced immunomodulatory effects of SeNPs were observed with the introduction of a low concentration of SeNPs (0.1 mg/kg). Increase in the administration time of SeNPs (0.1 mg/kg or 2.5 mg/kg) up to 28 days led to a decrease in the adhesive abilities of neutrophils and suppression of the expression of mRNA of adhesive molecules, as well as proteins involved in the generation of ROS, with the exception of NOX2; there was a tendency to suppress gene expression pro-inflammatory factors, which indicates the possible manifestation of immunosuppressive and anti-inflammatory effects of SeNPs during their long-term administration. Changes in the expression of selenoproteins also had features depending on the concentration and duration of the administered SeNPs. Selenoprotein P, selenoprotein M, selenoprotein S, selenoprotein K, and selenoprotein T were the most sensitive to the introduction of SeNPs into the mouse organism, which indicates their participation in maintaining the functional status of neutrophils, and possibly mediated the immunomodulatory effect of SeNPs.

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“…NETs are part of the defense process of the immune system where neutrophils create physical barriers to capturing and preventing the spread of pathogens (viruses, bacteria, and other microorganisms) in the extracellular medium [150] , [151] , [152] . Regarding the inflammatory process, it appears that Se-deficiency (possibly associated with the reduction of SELENOS) plays a role in the ROS-mediated NETs formation in an avian model of arteritis [153] , [154] .…”

Section: Se Involvement In the Immune And Inflammatory Responsesmentioning

confidence: 99%

Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review

Golin

Tinkov

Aschner

et al. 2023

Journal of Trace Elements in Medicine and Biology

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Effect of Copper, Zinc, and Selenium on the Formation of Bovine Neutrophil Extracellular Traps

Cited by 10 publications

References 31 publications

Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population

Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population

Modulation of the Functional State of Mouse Neutrophils by Selenium Nanoparticles In Vivo

Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review

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