Effect of coreactants on electrochemical glucose oxidation

Gough, David; Anderson, Frank L.; Giner, J.; Colton, Clark K.; Soeldner, J S

doi:10.1021/ac50029a029

Cited by 53 publications

(27 citation statements)

References 5 publications

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“…Though abiotic catalysts do not suffer from an inherent loss of activity the way enzymes do, researchers have demonstrated that in particular endogenous amino acids present in body fluids have a strong poisoning effect on platinum electrodes 2. 13–18 This poisoning effect is related to adsorption of the amino acids or their oxidation products at the platinum surface, which inhibits the electrochemical glucose oxidation (see for instance the work of Hibbert et al 15. and references therein for a detailed treatise on the underlying mechanisms).…”

Section: Introductionmentioning

confidence: 99%

Performance Loss of a Pt‐Based Implantable Glucose Fuel Cell in Simulated Tissue and Cerebrospinal Fluids

et al. 2014

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We present an electrode‐resolved analysis of the performance of platinum‐based abiotically catalyzed glucose fuel cells in realistically simulated tissue fluid (STF) and cerebrospinal fluid (SCF). The presence of amino acids and small organic molecules at physiological concentration leads to a drastic breakdown in fuel cell voltage, resulting in a maximum lifetime of 19 h in STF or 37 h in SCF. The performance loss mainly originates from catalyst poisoning at the anode, which causes 92 % or 80 % of the overall fuel cell voltage loss in STF or SCF, respectively. The results underline the necessity to further investigate and improve catalyst poisoning at the anode under realistic body conditions in order to improve the lifetime of platinum‐based implantable glucose fuel cells.

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Section: Introductionmentioning

confidence: 99%

Performance Loss of a Pt‐Based Implantable Glucose Fuel Cell in Simulated Tissue and Cerebrospinal Fluids

et al. 2014

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“…[25][26][27] It was generally found that the presence of amino acids had an inhibitory affect upon glucose oxidation, while the amino acids underwent oxidation themselves above about 650 mV (vs. Ag/AgCl) at a platinum rotating disk electrode (RDE) in Krebs-Ringer solution at pH 7.3. [25][26][27] It was generally found that the presence of amino acids had an inhibitory affect upon glucose oxidation, while the amino acids underwent oxidation themselves above about 650 mV (vs. Ag/AgCl) at a platinum rotating disk electrode (RDE) in Krebs-Ringer solution at pH 7.3.…”

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confidence: 99%

Voltammetry of Platinum in Artificial Perilymph Solution

Hibbert

Weitzner

Carter

2001

J. Electrochem. Soc.

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Mammalian cochlea perilymph contains amino acids and protein which have a major effect on the electrochemistry of an implanted auditory prosthesis. Cyclic voltammetry in an artificial perilymph solution shows that many amino acids adsorb at the platinum electrode diminishing oxidation of the metal, and also blocking hydrogen evolution. At anodic potentials > 900 mV vs. silver/silver chloride they are oxidized leaving adsorbed oxidation products. The sulfur-containing amino acids cysteine and methionine have the greatest effects. Protein (human serum albumen, HSA) has a similar but smaller effect. A solution containing HSA (2 mg mL Ϫ1 ), phenylalanine (175 M), glycine (396 M), and proline (40 M) in phosphate buffered saline is proposed as a suitable artificial perilymph solution having similar electrochemical and adsorption properties to perilymph. ) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of use (see 130.237.29.138 Downloaded on 2015-03-08 to IP ) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of use (see 130.237.29.138 Downloaded on 2015-03-08 to IP ) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of use (see 130.237.29.138 Downloaded on 2015-03-08 to IP ) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of use (see 130.237.29.138 Downloaded on 2015-03-08 to IP

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“…In polarograms with a mercury dropping electrode^ which permit quantitative measurement of oxidation and reduction processes by characteristic alterations of the current (polarographic steps), we detected no such changes, even at very high glucose concentrations. We must therefore conclude that the glucose-dependent increase of the electrode current as shown by Soeldner et al (14)(15)(16)(17)(18)(19) cannot be explained by a simple redox reaction of glucose at the electrodes.…”

Section: Discussionmentioning

confidence: 83%

“…Although NMR has been used satisfactorily for the determination of ATP in vivo in various organs (49), there is a considerable obstacle to its use for the determination of glucose in vivo; the relevant carbon nucleus for the determination of glucose possesses a relatively low signal intensity compared with the natural nuclides Ή, 15 N, 31 P and 13 C. In this respect, it would be much easier to determine the metabolically active glucose 6-phosphate.…”

Section: Discussionmentioning

confidence: 99%

Physicochemical Determinations of Glucose in vivo

Kruse-Jarres¹

1988

Clinical Chemistry and Laboratory Medicine

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Summary:Conventional methods for the determination of blood glucose are not suitable for application in vivo. It is therefore necessary to seek other methods for monitoring blood glucose as a controlled variable of pancreatic hormonal regulation. Physical methods are preferable to conventional chemical methods, because the chosen methods should not consume or chemically modify glucose. There are two main types of physical chemical methods, which can be considered for this purpose: 1) invasive methods, in which measurements are made directly in the blood stream, and 2) non-invasive methods. The first type is represented by electrochemical catalysts and fuel cells, the latter by spectroscopic procedures (mainly NMR-and IR-spectroscopy).

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Effect of coreactants on electrochemical glucose oxidation

Cited by 53 publications

References 5 publications

Performance Loss of a Pt‐Based Implantable Glucose Fuel Cell in Simulated Tissue and Cerebrospinal Fluids

Performance Loss of a Pt‐Based Implantable Glucose Fuel Cell in Simulated Tissue and Cerebrospinal Fluids

Voltammetry of Platinum in Artificial Perilymph Solution

Physicochemical Determinations of Glucose in vivo

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