Effect of Corneal Collagen Cross-Linking on Quality of Life in Patients with Bullous Keratopathy

Kaya, Emine; Eğrilmez, Sait; Palamar, Melis

doi:10.5336/ophthal.2014-42271

Cited by 3 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 34 ] Kaya et al , based on their prospective, comparative, nonrandomized study, concluded that CXL may be useful in the treatment of BK when waiting for keratoplasty, particularly in patients with intense pain, by temporarily improving the quality of life. [ 39 ]…”

Section: Discussionmentioning

confidence: 99%

Role of corneal collagen cross-linking in bullous keratopathy

Singh

Sinha

Mishra

et al. 2023

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

Corneal cross-linking (CXL), a corneal strengthening procedure, is known to alter anterior stroma swelling behavior and is one of the treatment modalities of bullous keratopathy (BK). There are multiple studies published on the role of CXL in the treatment of BK. These articles had heterogeneous study population, different protocols used, and variable conclusions. This systematic review aimed to determine the role of CXL in the treatment of BK. The primary outcomes considered were changes in central corneal thickness (CCT) after 1, 3, and 6 months of CXL. The secondary outcome measures were changes in visual acuity, corneal clarity, subjective symptoms, and complications after CXL. We included randomized control trials (RCTs), observational and interventional studies, and case series with reports of more than 10 cases in this review. In RCTs, the mean pre-CXL CCT (794.0 ± 178.5 μm) in the intervention group ( n = 37), decreased at 1 month (750.9 ± 154.3 μm) followed by a subsequent increase, but this difference was not significant during the 6-month follow-up ( P- value 0.28, 0.82, and 0.82 at 1, 3, and 6 months, respectively). In noncomparative clinical studies ( n = 188), the mean pre-CXL CCT (794.0 ± 178.5 μm) decreased at 1 month (710.9 ± 127.2 μm, P < 0.0001). Seven of the 11 articles included in the review reported no significant improvement in vision with CXL. The initial improvement in corneal clarity and clinical symptoms was not sustained. Current evidence suggests that CXL has short-term efficacy in the treatment of BK. More RCTs with high-quality evidence are needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of corneal collagen cross-linking in bullous keratopathy

Singh

Sinha

Mishra

et al. 2023

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“… 4 , 5 Palliative treatment methods are important for eyes without visual potential, especially in the management of pain. These methods include noninterventional approaches such as bandage contact lens use, 6 as well as surgical options such as phototherapeutic keratectomy, 7 cross-linking, 8 stromal micropunctures, 9 and conjunctival flaps. 9 …”

Section: Introductionmentioning

confidence: 99%

Palliative Efficacy of Intrastromal Amniotic Membrane Procedure in Symptomatic Bullous Keratopathy Patients

Furundaoturan

Palamar

Selver

2022

tjo

Self Cite

View full text Add to dashboard Cite

Objectives: To evaluate the palliative efficacy of the intrastromal human amniotic membrane (hAM) surgery technique in patients with symptomatic bullous keratopathy and limited visual potential. Materials and Methods: The study was carried out retrospectively by reviewing the medical data of 10 patients with poor visual prognosis who underwent intrastromal hAM surgery due to bullous keratopathy-related severe pain. Visual acuity, surgical indication, epithelization time, preoperative and postoperative pain scores, as well as anterior segment optical coherence tomography images and anterior segment photographs were obtained from the medical records. Results: Ten patients (6 females/4 males) were included in the study. Nine patients underwent surgery for pseudophakic bullous keratopathy and glaucoma, and 1 patient due to graft failure and glaucoma. The mean time for corneal epithelization was 27.10±13.05 days (range, 10-50), while the mean follow-up time was 37.5±1.6 months (range, 36-39.2). Subjective pain score improved in all patients after surgery. Suture-induced keratitis occurred during follow-up in one patient and was controlled with medical treatment. Conclusion: Intrastromal amniotic membrane surgery may be an alternative to keratoplasty for pain palliation in patients with limited visual prognosis after corneal transplantation when donor tissue is scarce. With this method, hAM remains on the ocular surface longer, and superficial stromal excision is believed to provide a more regular ocular surface and extend the asymptomatic period.

show abstract