Effect of Corneal Thickness on the Penetration of Topical Vancomycin

Spierer, Oriel; Regenbogen, Michael; Lazar, Moshé; Yatziv, Yossi

doi:10.1097/opx.0000000000000692

Cited by 3 publications

(2 citation statements)

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“…Similar results were reported in a study by Spierer et al that investigated the penetration of multiple administrations of vancomycin eye drops before cataract surgery in 58 patients with CCT between 458 μm and 635 μm [30]. Again, no significant difference of vancomycin concentration in the anterior chamber was found among patients enrolled in the study.…”

Section: Discussionsupporting

confidence: 87%

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

et al. 2019

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PurposeTo evaluate the presence and concentration of citicoline and its metabolites (choline, cytidine and uridine) in the vitreous body in human eyes after topical application of an ophthalmic solution of citicoline 2%, in vivo.MethodsTwenty-one subjects affected by epiretinal membrane with surgical indication for pars-plana vitrectomy underwent treatment with 1 drop 3 times/day of a solution of citicoline 2%, 0.2% high molecular weight hyaluronic acid and 0.01% benzalkonium chloride (OMK1, Omikron Italia s.r.l., Rome, Italy) 14 days before surgery and 2 hours prior to surgery. Five additional patients served as controls and received an OMK1 vehicle solution without citicoline. The vitreous samples were taken at the beginning of the pars-plana vitrectomy and analyzed for qualitative/quantitative determination of vitreous concentration of citicoline and its metabolites by means of high performance liquid chromatography.ResultsThe overall mean concentration of citicoline in patients treated with citicoline 2% solution was 406.72 ± 52.99 μg/mL, while the mean concentration of choline, cytidine and uridine was 180.88 ± 41.49 μg/mL, 44.45 ± 10.19 μg/mL and 330.41 ± 75.8 μg/mL, respectively. The concentration of citicoline in phakic eyes (n = 13, 366.61 ± 129.61 μg/mL) was lower compared to that found in pseudophakic eyes (n = 8, 435.89 ± 131.42 μg/mL) and the difference was not statistically significant. The concentration of citicoline in the control eyes was 45.66 ± 26.36 μg/mL, while the concentration of choline, cytidine and uridine were 17.21 ± 9.93 μg/mL, 6.24 ± 3.6 μg/mL and 172.80 ± 99.76 μg/mL, respectively.ConclusionCiticoline can reach the human vitreous in high concentration when administered in ophthalmic solution. This evidence contributes to the build-up of the pyramid of the evidences required for determining the role of citicoline administered in ophthalmic formulation in retinal and optic nerve neurodegenerative diseases.

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Section: Discussionsupporting

confidence: 87%

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

et al. 2019

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“…Corneal endothelial cell density showed similar results. Several clinical studies have reported no significant correlation between the corneal thickness and drug concentration in the aqueous humor [ 35 , 36 ]. A positive correlation was reported between corneal thickness and timolol concentration in the aqueous humor, but the correlation was weak [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Patient Factors Influencing Intraocular Penetration of Brimonidine-Related Eye Drops in Adults: A Post Hoc Pooled Analysis

Kunikane,

Orii,

Inoue

et al. 2023

Ophthalmol Ther

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Introduction:The factors related to the ocular penetration of drugs after the administration of eye drops in humans have not been examined in detail. Therefore, this study assessed the influence of patient factors on the intraocular penetration of eye drops. Methods: A pooled analysis was performed on the data of 42 participants from three studies to evaluate the ocular pharmacokinetics in humans after the topical application of brimonidine-related eye drops. The patients were scheduled for vitrectomy and received brimonidine-related eye drops (0.1% brimonidine tartrate ophthalmic solution, 0.1% brimonidine tartrate and 0.5% timolol fixed-combination ophthalmic solution, or 0.1% brimonidine tartrate and 1% brinzolamide fixed-combination suspension) twice daily for 1 week. We analyzed the effects of patient factors (sex, the presence or absence of lens, age, corneal thickness,

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PRGF exerts more potent proliferative and anti-inflammatory effects than autologous serum on a cell culture inflammatory model

Anitua

Muruzábal

Fuente

et al. 2016

Experimental Eye Research

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Effect of Corneal Thickness on the Penetration of Topical Vancomycin

Abstract: Corneal thickness does not influence the penetration of topically applied vancomycin into the anterior chamber.

Cited by 3 publications

References 25 publications

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

Patient Factors Influencing Intraocular Penetration of Brimonidine-Related Eye Drops in Adults: A Post Hoc Pooled Analysis

PRGF exerts more potent proliferative and anti-inflammatory effects than autologous serum on a cell culture inflammatory model

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