Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Takagi, Satoshi; Miura, Toshihiro; Ishibashi, Chinami; Kawata, Takanori; Ishihara, Eriko; Gu, Yeunhwa; Ishida, Tatsuro

doi:10.3177/jnsv.54.266

Cited by 19 publications

(9 citation statements)

References 10 publications

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“…In this study, a sugar solution was administered 30 min orally after the corosolic acid, and blood samples were drawn at 30, 60, and 120 min [38]. These results agree with the observations of Suzuki et al who showed that an extract of Banaba leaves inhibited sucrase activity and exerted hypoglycemic effects through multiple mechanisms [27].…”

Section: Animal Studiessupporting

confidence: 86%

Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosaL.) and Corosolic Acid

Miura

Takagi

Ishida

2012

Evidence-Based Complementary and Alternative Medicine

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Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This paper summarizes the current literature regarding Banaba and its constituents. The hypoglycemic effects of Banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects, and in vitro systems using water soluble Banaba leaf extracts, corosolic acid, and ellagitannins. Corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic and antioxidant activities. The beneficial effects of Banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis, and the regulation of lipid metabolism. These effects may be mediated by PPAR and other signal transduction factors. Banaba extract, corosolic acid, and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits.

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Section: Animal Studiessupporting

confidence: 86%

Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosaL.) and Corosolic Acid

Miura

Takagi

Ishida

2012

Evidence-Based Complementary and Alternative Medicine

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“…In a study in mice, Takagi et al () demonstrated that an oral dose of 10 mg/kg corosolic acid suspended in water inhibited the intestinal hydrolysis of sucrose but not maltose or lactose, thereby at least in part facilitating the lowering of blood glucose levels since sucrose is a disaccharide composed of glucose plus fructose. In this study, a sugar solution was administered 30 min orally after the corosolic acid, and blood samples were drawn at 30, 60 and 120 min.…”

Section: Animal Studiesmentioning

confidence: 99%

A Review of the Efficacy and Safety of Banaba (Lagerstroemia speciosa L.) and Corosolic Acid

Stohs

Miller²,

Kaats

2011

Phytotherapy Research

111

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Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This review summarizes the current literature regarding banaba and its constituents. The hypoglycemic effects of banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects and in vitro systems using water soluble banaba leaf extracts, corosolic acid-standardized extracts, and purified corosolic acid and ellagitannins. Pure corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral, antineoplastic and osteoblastic activities. The beneficial effects of banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis and the regulation of lipid metabolism. These effects may be mediated by PPAR, MAP K, NF-κB and other signal transduction factors. No adverse effects have been observed or reported in animal studies or controlled human clinical trials. Banaba extract, corosolic acid and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits.

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“…This acid is one of the active constituents of Lagerstroemia speciosa L., banaba leaf. The plant is used traditionally in Philippines to treat diabetes and was studied by Takagi et al [89] who referred the antidiabetic effect to the inhibition of sucrose hydrolysis. However, the effect of corosolic acid on GLUT-4 can not be ruled out, although this requires further verification In another study [90] , the 3T3-L1 adipocytes were used to prove that the methanolic extract of Liriope platyphylla Wang et Tang ( LPWT), Liliaceae, increased insulin-induced glucose uptake in adipocytes, by virtue of its homoisoflavone.…”

Section: Enhancement Of Glucose Uptake and Upregulation Of Glucose Trmentioning

confidence: 99%

Phytotherapy in diabetes: Review on potential mechanistic perspectives

El‐Abhar

Schaalan

2014

WJD

110

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Diabetes mellitus (DM) is a widely spread epidemic disease that results from the absence of insulin, decreased secretion and/or impaired function. Since DM is a multifactorial disease, the available pharmaceuticals, despite their sensible treatment, target mostly one pathway to control hyperglycemia and encounter several side effects. Therefore, new therapeutic paradigms aim to hit several pathways using only one agent. Traditionally, antidiabetic plants and/or their active constituents may fulfill this need. More than 200 species of plants possess antidiabetic properties which were evaluated mostly by screening tests without digging far for the exact mode of action. Searching among the different literature resources and various database and in view of the above aspects, the present article provides a comprehensive review on the available antidiabetic plants that have been approved by pharmacological and clinical evaluations, and which their mechanism(s) of action is assured. These plants are categorized according to their proved mode of action and are classified into those that act by inhibiting glucose absorption from intestine, increasing insulin secretion from the pancreas, inhibiting glucose production from hepatocytes, or enhancing glucose uptake by adipose and muscle tissues. The current review also highlights those that mimic in their action the new peptide analogs, such as exenatide, liraglutide and dipeptidylpeptidase-4 inhibitors that increase glucagon-like peptide-1 serum concentration and slow down the gastric emptying.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypoglycaemic nutraceuticals; Antidiabetic phyto-constituents; Medicinal plants; Phytotherapy; Diabetes mellitus Core tip: Diabetes is a serious metabolic disorder that is currently treated by different types of synthetic oral hypoglycemic agents, in addition to insulin. However, due to the unwanted side effects, the efficacies of these compounds are debatable and there is a demand for new compounds for the treatment of diabetes. Therefore, attention has been directed towards nutraceuticals originating from plants that are rich in antidiabetic phyto-constituents. Although the evidenced-based therapeutic usage of many plants is scarce, the plants cited in this review are those reputed traditionally for their antidiabetic effect and that were verified either experimentally or clinically.El-Abhar HS, Schaalan MF. Phytotherapy in diabetes: Review on potential mechanistic perspectives. World J Diabetes 2014; 5(2): 176-197 Available from:

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Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Cited by 19 publications

References 10 publications

Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosaL.) and Corosolic Acid

Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosaL.) and Corosolic Acid

A Review of the Efficacy and Safety of Banaba (Lagerstroemia speciosa L.) and Corosolic Acid

Phytotherapy in diabetes: Review on potential mechanistic perspectives

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