Effect of correction of endothelial dysfunction on clinical and immunological parameters in patients with bronchial asthma

Abstract

Aim:The aim of the study was to study the effect of correction of endothelial dysfunction on the clinical and immunological parameters of patients with bronchial asthma with a long history of the disease. Materials and methods:We examined 86 patients with mild and moderate-onset persistent asthma at the age of 18-55 years (38.5±4.2 years), with a duration of disease more than 12 years (on average 16+4.5years). Two groups were formed by random sampling. Patients of the main group (n=44), in addition to the standard basic therapy (GINA, 2007) received a nitric oxide donor -L-arginine. The comparison group (n=42) received only basic therapy. As a control, 15 practically healthy persons were examined. The condition of the endothelial system was assessed before and after the ten-day course, and also after 1 month of treatment according to the following indices. In the dynamics of treatment, the immunological parameters in the blood and in the condensate of exhaled air were also evaluated. Conclusion:In patients with a long course of persistent asthma of moderate severity with the use of L-arginine in addition to basic therapy, which contributes to an earlier and reliable improvement of the immunological parameters studied. Citation: Alyavi AL, Bazarov SA, Sadykova GA, et al. Effect of correction of endothelial dysfunction on clinical and immunological parameters in patients with bronchial asthma. Int J Radiol Radiat Ther. 2018;5(2):76-78.