EFFECT OF CORTICOSTERONE ON SERUM CONCENTRATIONS OF α2u-GLOBULIN AND ON SPERMATOGENESIS IN OESTROGEN-TREATED RATS

Biswas, N. M.; Ghosh, Pradip; Neuhaus, Otto W.

doi:10.1677/joe.0.0920309

Cited by 10 publications

(6 citation statements)

References 24 publications

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“…Hypophysectomy (Roy -1973) reduces azu-globulin excretion in the male rat and adrenalectomy also has the same effect but replacement therapy with glucocorticoid induces azu-globulin in adrenalectomized rats (Irwin et al -1971). An increased concentration of serum az u-globulin after corticosterone treatment in estrogentreated rats is consistent with previous findings (Biswas et al -1982). Since our recent data show that administration of a2 u-globulin in the male rats stimulates gonadotrophin and testosterone synthesis (Biswas et al -1983), the significant rise of serum levels of FSH, LH and testosterone after corticosterone treatment in estrogen-treated rats indicates that corticosterone, by inducing az u-globulin, stimulates the synthesis of gonadotrophms and concomitant increase in serum testosterone is possibly the effect of increased serum concentration of LH.…”

Section: Discussionsupporting

confidence: 93%

“…Administration of corticosterone in the estrogenized rats reduces this percentage of degeneration from 5 1.26% to 35.67%. The mechanism by which corticosterone stimulates spermatogenesis is not definitely known, although azu-globulin (Roy et al -1976) or corticosterone (Biswas et al -1982) alone can prevent spermatogenic degeneration in estrogen-treated rats.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, estrogen treatment in the rats affects spermatogenesis (Roy et al -1976) and the activities of testicular steroidogenic enzymes (Samuels et d. -1969) with simultaneous decrease in serum levels of gonadotrophins (Verjans et al -1974). Previous observations showed that azu-globulin (Roy et al -1976) or corticosterone (Biswas et al -1982) prevents testicular degeneration in estrogen-treated rats.…”

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confidence: 94%

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Studies on the Effect of Corticosterone Treatment on Testicular Activity, Serum Concentration of Gonadotrophins, Testosterone and α2u-Globulin in Rats Pre-Treated with Estrogen

Ghosh

Biswas

2009

Andrologia

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Adult male rats were treated Hiith estradiol-170 (50 pg/100 g body wt./day) for 7 days. When the animals were killed 14 days later, the levels of serum gonadotrophins, testosterone and azu-Globulin as well as the weight of sex organs were reduced, testicular 170-hydroxysteroid dehydrogenase (1 70-HSD) activity was also suppressed; spermatogenesis was inhibited. Administration of corticosterone (2 mg/day) for 14 days to estrogentreated rats increased the concentration of gonadotrophins, testosterone and az u-globulin in the serum. The weight of accessory sex organs and spermatogenesis appeared to be normal while 170-HSD activity increased in estrogen-treated rats after treatment with corticosterone. It is concluded that corticosterone has an effect on testicular function by inducing a2 .-globulin and gonadotrophins in estrogen treated rats. Untersuchungen uber die Auswirkungen einer Corticosteroidbehandlung auf die Hodenaktivitat, die Gonadotropin-, Testosteron-und az u-Globulin-Konzentration im Serum von ostrogenbehandelten RattenZusammenfassung: Erwachsene mannliche Ratten wurden mit 170-Ostradiol (50pg/ 100 g K.G./Tag) iiber 7 Tage behandelt. Bei Totung der Tiere 14 Tage spater waren die Serumkonzentrationen der Gonadotropine, des Testosterons und des az ,-Globulins ebenso wie das Gewicht der Geschlechtsorgane reduziert wie auch die Aktivitat der testikularen 17&Hydroxy-Steroid-Dehydrogenase (1 7/.?-HSD) unterbunden war, Die Spermatogenese war unterdriickt. Die Gabe von Corticosteroid (2 mg/Tag) iiber 14 Tage steigerte bei den ostrogenbehandelten Ratten die Serumkonzentration der Gonadotropine, des Testosterons und des az .-Globulins. Das Gewicht der Geschlechtsorgane und die Spermatogenese erschienen normal wahrend die 1 70-HSD-Aktivitiit bei den ostrogenbehandelten Ratten nach Behandlung mit Corticosteroid anstieg. Es wird geschlossen, daB Corticosteroid eine Wirkung auf die Hodenfunktion iiber die Bildung des azuGlobulins und der Gonadotropine bei ostrogenbehandelten Ratten hat. Introduction parenchymal cells in the adult male rats (Roy andRoy Alpha-2u-globulin, a sexdependent urinary protein, is synthesized by the hepatic

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 94%

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Studies on the Effect of Corticosterone Treatment on Testicular Activity, Serum Concentration of Gonadotrophins, Testosterone and α2u-Globulin in Rats Pre-Treated with Estrogen

Ghosh

Biswas

2009

Andrologia

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“…A hypogonadal state can also be induced in male rats by the administration of oestrogen which also causes a reduction in the concentration of serum a2u-globulin (Biswas, Ghosh & Neuhaus, 1982). This effect of oestrogen can be prevented by the concomitant administration of corticosterone which prevents the decrease in a2u-globulin synthesis (Ghosh & Biswas, 1984).…”

Section: Introductionmentioning

confidence: 99%

Effect of dihydrotestosterone on serum concentrations of α2u-globulin and on spermatogenesis in melatonin-treated rats

Mandal

Ghosh²,

Biswas³

1990

Journal of Endocrinology

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Adult male rats were given s.c. injections of melatonin (400 micrograms/100 g body weight per day) for 14 days. On day 15, the weights of the testis and accessory sex organs were less, testicular 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activity was inhibited, spermatogenesis was suppressed and serum levels of gonadotrophins, testosterone and alpha 2u-globulin were decreased compared with control animals injected with vehicle. In a third group of rats given the same dose of melatonin for 14 days, administration of dihydrotestosterone (DHT) at a dose of 25 micrograms/100 g body weight per day on days 8-14 resulted in serum levels of alpha 2u-globulin, FSH, LH and testosterone and testicular 17 beta-HSD activity similar to those seen in vehicle-injected control animals. Weights of the testes and accessory sex organs and spermatogenesis were normal after administration of DHT in melatonin-treated rats. In another group of rats, the depressive effects of melatonin treatment on plasma gonadotrophins were reversed by the administration of alpha 2u-globulin on days 8-14. It was concluded that treatment with DHT prevents the depressive action of melatonin on testicular function by inducing the synthesis of alpha 2u-globulin.

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“…Alpha-2 μ globulin was expressed in a male rat liver, and the expression was changed under oxidative stress, which affected the developmental and multi-hormonal regulation [21][22][23][24] . Trichloroethylene appeared to be the most efficient in decreasing the expression of alpha-2 μ globulin in rat liver, suggesting that trichloroethylene may affect the developmental process in animals ( Figure 1C).…”

Section: Antibody Arraymentioning

confidence: 99%

Biomarker analysis of rat livers exposed to different toxic pollutants (VOCs and PAHs) using an antibody array

Kim

Lee²,

Hwang

et al. 2010

BioChip J

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We have developed an antibody microarray chip for biomarker analysis in rat livers exposed to five different toxic pollutants: volatile organic compounds (VOCs), dichloromethane, ethylbenzene, and trichloroethylene; and polycyclic aromatic hydrocarbons (PAHs), benzoanthracene and phenanthrene. The antibody chip consisted of antibodies against different biomarkers: alpha-2 μ globulin, glutathione S transferase (GST)-α, Hemoglobin β, and Phenylalanine hydroxylase. VOC-and PAH-treated rat livers showed differential expression patterns of the biomarker proteins. These results demonstrate that a protein chipbased antibody array is useful for the analysis of biomarkers induced by environmental toxic pollutants and can be a powerful tool to study the mechanisms of pollutants in biological samples.

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EFFECT OF CORTICOSTERONE ON SERUM CONCENTRATIONS OF α2u-GLOBULIN AND ON SPERMATOGENESIS IN OESTROGEN-TREATED RATS

Cited by 10 publications

References 24 publications

Studies on the Effect of Corticosterone Treatment on Testicular Activity, Serum Concentration of Gonadotrophins, Testosterone and α2u-Globulin in Rats Pre-Treated with Estrogen

Studies on the Effect of Corticosterone Treatment on Testicular Activity, Serum Concentration of Gonadotrophins, Testosterone and α2u-Globulin in Rats Pre-Treated with Estrogen

Effect of dihydrotestosterone on serum concentrations of α2u-globulin and on spermatogenesis in melatonin-treated rats

Biomarker analysis of rat livers exposed to different toxic pollutants (VOCs and PAHs) using an antibody array

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