Effect of Corticotrophin on Secretion of Aldosterone

Muller, A. F.; Riondel, A. M.; Manning, E. L.

doi:10.1016/s0140-6736(56)90269-0

Cited by 34 publications

(20 citation statements)

References 5 publications

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“…A 1 hr infusion resulted in a tenfold rise in plasma aldosterone which, without altering metabolic clearance, would reflect a comparable change in adrenal secretion. Although earlier work on the role of pituitary ACTH indicated that the pituitary was not necessary for aldosterone secretion in various states, recent publications have reiterated the importance of ACTH (18)(19)(20)(21)(22). Aldosterone hypersecretion and sodium conservation are much more effective when the pituitary is intact and is reduced by hypophysectomy.…”

Section: Resultsmentioning

confidence: 99%

Stimulation and suppression of aldosterone in plasma of normal man and in primary aldosteronism

Horton¹

1969

J. Clin. Invest.

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A B S T R A C T The effect of stimulating and suppressive influences on plasma aldosterone in normal man and in patients with primary aldosteronism were studied using a sensitive double-isotope derivative assay for aldosterone.In normal sitting subjects, values were 9.2 ±0.9 (SE) mug/100 ml and in subjects supine for 1 hr plasma aldosterone was 5.2 ±0.4 (SE) mug/100 ml. Adrenocorticotropic hormone (ACTH), 0.5 U/hr, produced a rise of 46.8 ±22 (SE) mug which was similar to the 1-hr effect of an infusion of a synthetic ACTH (j112, Cortrosyn). Angiotensin II in pressor amounts also increased plasma aldosterone 21.5 ±2.9 (SE) without change in plasma cortisol, whereas a subpressor dose (1) had minimal effect.Fludrocortisone, 1.2 mg/day for 3 days, suppressed plasma aldosterone levels to 1.8 ±0.7 (SE) mug/100 ml in five normal sitting subjects (P < 0.01); however, dexamethasone, 2 mg/day for 1-2 days, did not lower aldosterone concentration in plasma.In six patients with primary aldosteronism, plasma aldosterone on a normal sodium diet was 39.1 ±4.4 (SE) which differed significantly from normal sitting or supine subjects (P < 0.001 ). In contrast to the normal subjects, neither a pressor infusion of angiotensin II for 1 hr., nor fludrocortisone, 1.2 mg/day for 3 days, impressively altered plasma aldosterone levels.This approach appears to be useful for the study of the acute physiology and control mechanisms of aldosterone production in normal and hypertensive man.

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Section: Resultsmentioning

confidence: 99%

Stimulation and suppression of aldosterone in plasma of normal man and in primary aldosteronism

Horton¹

1969

J. Clin. Invest.

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“…The response to different corticotropin preparations (3,7,(8)(9)(10) suggests that ACTH influences aldosterone production. The present data show that the 90 per cent drop in aldosterone and corticosterone secretion which follows hypophysectomy was blocked completely by an ACTH preparation.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, our knowledge is incomplete on the importance of specific anterior pituitary hormones. Several studies (3,7,(8)(9)(10) have demonstrated an increase in aldosterone secretion or urinary aldo-* This investigation was aided in part by Grant A-1944 from the National Institutes of Health, Bethesda, Md.1 The phrases "aldosterone secretion" or "hypersecretion of aldosterone" have been used to refer to actual measurements of the rate of secretion by the adrenal gland into the effluent plasma and are to be distinguished from urinary aldosterone excretion. sterone excretion following administration of various corticotropin preparations, but the data are inadequate to establish the role of ACTH in secondary hyperaldosteronism.2…”

mentioning

confidence: 99%

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confidence: 99%

“…Furthermore, our knowledge is incomplete on the importance of specific anterior pituitary hormones. Several studies (3,7,(8)(9)(10) have demonstrated an increase in aldosterone secretion or urinary aldo-sterone excretion following administration of various corticotropin preparations, but the data are inadequate to establish the role of ACTH in secondary hyperaldosteronism. 2 The question of the role of the anterior pituitary in the control of aldosterone secretion was reopened by the finding of a 76 to 97 per cent fall in adrenal vein aldosterone output following hypophysectomy of dogs with experimental secondary hyperaldosteronism ( 11).…”

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The Role of the Anterior Pituitary in the Control of Aldosterone Secretion in Experimental Secondary Hyperaldosteronism*

Davis¹,

Yankopoulos²,

Lieberman³

et al. 1960

J. Clin. Invest.

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Previous reports (1-9) have delegated a secondary role to anterior pituitary hormones in the control of aldosterone secretion.' Although hypophysectomy resulted in decreased aldosterone secretion (3) or reduced urinary aldosterone output (2), hyperaldosteronuria, marked sodium (Na) retention and ascites occurred in the absence of the adenohypophysis in dogs with thoracic inferior vena cava constriction (2). Also, in patients with hypopituitarism, Luetscher and Axelrad (6) and Hernando and associates (7) found that urinary aldosterone output was within normal limits in some patients on an unselected diet or a normal salt intake, and Liddle, Duncan 'and Bartter (8) reported hyperaldosteronuria in one patient with hypopituitarism on a low Na diet.However, no conclusive evidence of hypersecretion 1 of aldosterone in the absence of anterior pituitary hormones has been reported. The critical pertinent data on the rate of aldosterone secretion during stimulation which produces hypersecretion in normal animals have not been reported for hypophysectomized dogs or patients. It is important that studies in man be conducted on hypophysectomized patients since patients with so-called panhypopituitarism may not have loss of all anterior pituitary function. Furthermore, our knowledge is incomplete on the importance of specific anterior pituitary hormones. Several studies (3,7,(8)(9)(10) have demonstrated an increase in aldosterone secretion or urinary aldo-* This investigation was aided in part by Grant A-1944 from the National Institutes of Health, Bethesda, Md.1 The phrases "aldosterone secretion" or "hypersecretion of aldosterone" have been used to refer to actual measurements of the rate of secretion by the adrenal gland into the effluent plasma and are to be distinguished from urinary aldosterone excretion. sterone excretion following administration of various corticotropin preparations, but the data are inadequate to establish the role of ACTH in secondary hyperaldosteronism.2The question of the role of the anterior pituitary in the control of aldosterone secretion was reopened by the finding of a 76 to 97 per cent fall in adrenal vein aldosterone output following hypophysectomy of dogs with experimental secondary hyperaldosteronism ( 11). In the present report, data are presented on the efficacy of ACTH 3 in preventing this fall in aldosterone secretion which follows hypophysectomy. Large doses of cortisone have been administered to inhibit ACTH secretion in dogs with hyperaldosteronism secondary to caval constriction; the resultant effects on aldosterone and corticosterone production were observed. Subsequently, the effects of hypophysectomy and ACTH were studied in these animals. Also, the effects of synthetic a-melanophore-stimulating hormone (MSH) and of highly purified preparations of natural a-and ,B-MSH have been studied. Attempts have been made to stimulate hypersecretion of aldosterone in simple hypophysectomized dogs by 1) a low Na diet and 2) acute constriction of the thoracic inferior vena cava.2 In this pap...

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Role of Trophic Hormones in Regulation of Growth and Function of Responsive Cells

Rao

Long

Gondos³

et al. 1984

Regulation of Target Cell Responsiveness

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Effect of Corticotrophin on Secretion of Aldosterone

Cited by 34 publications

References 5 publications

Stimulation and suppression of aldosterone in plasma of normal man and in primary aldosteronism

Stimulation and suppression of aldosterone in plasma of normal man and in primary aldosteronism

The Role of the Anterior Pituitary in the Control of Aldosterone Secretion in Experimental Secondary Hyperaldosteronism*

Role of Trophic Hormones in Regulation of Growth and Function of Responsive Cells

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