Effect of Cortisone on the Intestinal Absorption of Calcium in Rats

Winter, Michael; Morava, E.; Simon, G.

doi:10.1159/000137178

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…For calculating the drug's effective permeability values (Peff), the measured C out /C in ratio was corrected for water transport using Eq. (3) [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

“…DMP is a simulation strategy involving cyclodextrins, nanoparticles, solid dispersions, and permeation enhancers to overcome this problem. However, in recent years, it has been observed that using lipid-based formulations improved the oral bioavailability of this type of drug [ 6 , 7 ]. The most common approach is to incorporate drug molecules into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions, and liposomes.…”

Section: Introductionmentioning

confidence: 99%

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Enhancing Oral Bioavailability of Domperidone Maleate: Formulation, In vitro Permeability Evaluation In-caco-2 Cell Monolayers and In situ Rat Intestinal Permeability Studies

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et al. 2024

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Background: The domperidone maleate, a lipophilic agent classified as a Biopharmaceutical Classification System Class II substance with weak water solubility. Self- Emulsifying Drug Delivery System is a novel approach to improve water solubility and, ultimately bioavailability of drugs. Objective: This study aimed to develop and characterize new domperidone-loaded self-emulsifying drug delivery systems as an alternative formulation and to evaluate the permeability of domperidone-loaded self-emulsifying drug delivery systems by using Caco-2 cells and via single-pass intestinal perfusion method. Method: Three self-emulsifying drug delivery systems were prepared and characterized in terms of pH, viscosity, droplet size, zeta potential, polydispersity index, conductivity, etc. Each formulation underwent 10, 100, 200, and 500 times dilution in intestinal buffer pH 6.8 and stomach buffer pH 1.2, respectively. Female Sprague Dawley rats were employed for in situ single-pass intestinal perfusion investigations. Results: Results of the study revealed that the ideal self-emulsifying drug delivery systems formulation showed narrow droplet size, ideal zeta potential, and no conductivity. Additionally, as compared to the control groups, the optimum formulation had better apparent permeability (12.74 ± 0.02×10-4) from Caco-2 cell monolayer permeability experiments. The study also revealed greater Peff values (2.122 ± 0.892×10-4 cm/s) for the optimal formulation from in situ intestinal perfusion analyses in comparison to control groups (Domperidone; 0.802±0.418×10-4 cm/s). Conclusion: To conclude, prepared formulations can be a promising way of oral administration of Biopharmaceutical Classification System Class II drugs.

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“…For calculating the drug's effective permeability values (Peff), the measured C out /C in ratio was corrected for water transport using Eq. (3) [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancing Oral Bioavailability of Domperidone Maleate: Formulation, In vitro Permeability Evaluation In-caco-2 Cell Monolayers and In situ Rat Intestinal Permeability Studies

Okur

Çağlar

Kaynak

et al. 2024

CDD

View full text Add to dashboard Cite

show abstract

“…vitamin D3 by mouth. Two days later, intestinal calcium absorption was examined by an in-vivo loop method described earlier (Winter, Morava & Simon, 1969). In the anaesthetized rats duodenal and jejunal loops were tied at both ends and a known amount of 45Ca-labelled calcium chloride was injected into the lumen.…”

Section: Methodsmentioning

confidence: 99%