Effect of COVID-19 on asthma exacerbation

Salciccioli, Justin D.; She, Lilin; Tulchinsky, Abigail; Rockhold, Frank; Cardet, Juan Carlos; Israel, Elliot

doi:10.1016/j.jaip.2021.04.038

Cited by 41 publications

(34 citation statements)

References 9 publications

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“…155 A significant reduction in asthma exacerbation was detected during COVID‐19 compared with previous years despite they were more expected to avoid or delay medical visits due to fear of referring to medical facilities. 156 , 157 , 158 …”

Section: Methodsmentioning

confidence: 99%

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

Sabetkish

Rahmani

2021

Health Science Reports

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Background and Aims The Coronavirus disease 2019 (COVID‐19) pandemic globally changed the priorities of medical and surgical procedures. It has caused many healthcare systems to stop performing their routine screenings. Altering medical clinics to COVID‐19 referral centers, lockdowns, and the public fear to refer to medical centers caused a significant reduction in the referral rate; especially in the elderly. This short review article highlights the transform in clinical practice during the post‐COVID era and the need for future medical revolutions. Methods A comprehensive literature search was separately performed by both authors. The articles published between 2019 and August 2021 were included in this study and selected according to a quality appraisal method. Results We have summarized the possible corresponding changes in the diagnosis and treatment of all fields of medical care including internal medicine, surgical, and minor subcategories after the COVID‐19 pandemic. We have also discussed the potential impacts of the pandemic on all these different categories and subcategories of medicine, including the outpatient setting and clinical work. We do believe that the lack of routine check‐ups has led to an increase in the stage of disease in patients with a previously diagnosed problem. On the other hand, the dramatic change in the lifestyle of the population including restricted mobility and increased consumption of unhealthy food has caused metabolic syndrome and other new diseases that have not been diagnosed and properly managed. Conclusion Our findings revealed the urgent need for public health awareness. It indicated the need to carry out both psychological and screening approaches in the post‐COVID era to not miss patients with a chronic disease and new cases who were undiagnosed during the COVID pandemic.

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Section: Methodsmentioning

confidence: 99%

The overall impact of COVID‐19 on healthcare during the pandemic: A multidisciplinary point of view

Sabetkish

Rahmani

2021

Health Science Reports

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“…Controversially, patients who suffer from non-TH2-predominant asthma often have comorbidities such as obesity or cardiovascular diseases and might have a higher risk for severe illness ( 79 ). According to the latest literature, asthmatic exacerbation rates during the pandemic were reduced compared to numbers of 2019 ( 80 ). This effect might be due to the reduction of social contacts, the use of facial masks and the keeping of distance to other people.…”

Section: Impact Of Type III Interferon Secretion On the Respiratory Tractmentioning

confidence: 99%

Regulation and Function of Interferon-Lambda (IFNλ) and Its Receptor in Asthma

et al. 2021

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Asthma is a chronic respiratory disease affecting people of all ages, especially children, worldwide. Origins of asthma are suggested to be placed in early life with heterogeneous clinical presentation, severity and pathophysiology. Exacerbations of asthma disease can be triggered by many factors, including viral respiratory tract infections. Rhinovirus (RV) induced respiratory infections are the predominant cause of the common cold and also play a crucial role in asthma development and exacerbations. Rhinovirus mainly replicates in epithelial cells lining the upper and lower respiratory tract. Type III interferons, also known as interferon-lambda (IFNλ), are potent immune mediators of resolution of infectious diseases but they are known to be involved in autoimmune diseases as well. The protective role of type III IFNs in antiviral, antibacterial, antifungal and antiprotozoal functions is of major importance for our innate immune system. The IFNλ receptor (IFNλR) is expressed in selected types of cells like epithelial cells, thus orchestrating a specific immune response at the site of viruses and bacteria entry into the body. In asthma, IFNλ restricts the development of TH2 cells, which are induced in the airways of asthmatic patients. Several studies described type III IFNs as the predominant type of interferon increased after infection caused by respiratory viruses. It efficiently reduces viral replication, viral spread into the lungs and viral transmission from infected to naive individuals. Several reports showed that bronchial epithelial cells from asthmatic subjects have a deficient response of type III interferon after RV infection ex vivo. Toll like Receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents, and induce the development of antiviral and antibacterial immunity. We recently discovered that activation of TLR7/8 resulted in enhanced IFNλ receptor mRNA expression in PBMCs of healthy and asthmatic children, opening new therapeutic frontiers for rhinovirus-induced asthma. This article reviews the recent advances of the literature on the regulated expression of type III Interferons and their receptor in association with rhinovirus infection in asthmatic subjects.

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“… 5 , 8 , 9 , 10 Substantial reductions in asthma exacerbations during the COVID-19 pandemic have also been seen among individuals who are non-atopic. 2 In general, we suggest greater caution in tapering an atopic child with asthma during the pandemic, even if their asthma is well controlled. The second factor is baseline risk for poor asthma outcomes, as outlined in the GINA strategy, which includes low pulmonary function, smoke exposure, and previous severe exacerbations.…”

mentioning

confidence: 88%

“…A substantial reduction in asthma exacerbations in both children and adults has been seen in many countries worldwide during the COVID-19 pandemic. 1 , 2 The cause of this reduction is likely to be multifactorial, but at least partly due to population-level public health measures, such as physical distancing, masking, and hand washing, which reduce broad viral transmission. 2 This improvement in asthma control poses an interesting clinical dilemma: should clinicians consider tapering asthma medications in children during the pandemic in the face of good asthma control?…”

mentioning

confidence: 99%

“… 1 , 2 The cause of this reduction is likely to be multifactorial, but at least partly due to population-level public health measures, such as physical distancing, masking, and hand washing, which reduce broad viral transmission. 2 This improvement in asthma control poses an interesting clinical dilemma: should clinicians consider tapering asthma medications in children during the pandemic in the face of good asthma control? Furthermore, if medicines are reduced during the COVID-19 pandemic, should clinicians return to the pre-COVID-19 schedule as respiratory precautions are gradually relaxed?…”

mentioning

confidence: 99%

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