Effect of CPAP Therapy on Symptoms of Nocturnal Gastroesophageal Reflux among Patients with Obstructive Sleep Apnea

Tamanna, Sadeka; Campbell, Douglas L.; Warren, Richard; Ullah, Mohammad

doi:10.5664/jcsm.6126

Cited by 25 publications

(18 citation statements)

References 20 publications

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“…(2) AHI and weak acid re ux were both signi cantly correlated with chronic cough, AHI was also correlated with weak acid re ux. This ndings are consistent with other studies that CPAP treatment can improve GER [10,18] and daytime sleepiness [10] . Previous studies investigated the effect of CPAP on GER and OSA, but there had been no analysis focus on the effect of CPAP on chronic cough in OSA concomitant GER patients.…”

Section: Discussionsupporting

confidence: 93%

“…Previous study have concluded that proton pump inhibitor (PPI) therapy for GER can not improve cough in GER patients [9] . Continuous positive airway pressure (CPAP) has been shown to improve GER events in OSA patients [10] . Unfortunately, as far as OSA and GER-related cough is concerned, the therapeutic management remains largely empirical.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Continuous Positive Airway Pressure on Chronic Cough in Obstructive Sleep Apnea Concomitant Gastroesophageal Reflux Patients: A Retrospective Observational Study

Meng

et al. 2021

Preprint

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Background:Chronic cough is common in obstructive sleep apnea. The aetiology of chronic cough in obstructive sleep apnea patients could be multifactorial. Several studies have reported high incidence rates of gastroesophageal reflux in obstructive sleep apnea patients, and gastroesophageal reflux may be one of causes of chronic cough in OSA patients. This study aimed to investigate the effect of continuous positive airway pressure on chronic cough in obstructive sleep apnea concomitant gastroesophageal reflux patients.Methods: Obstructive sleep apnea concomitant gastroesophageal reflux patients who also suffered chronic cough were enrolled. Patients who accepted continuous positive airway pressure as treatment group, and the patients who accepted general treatment (diet control, moderate exercise, sleeping on your side, limiting alcohol consumption and proton pump inhibitor±mosapride) as control group. Effects of different treatment modalities on chronic cough were assessed, and the correlation between chronic cough, obstructive sleep apnea and gastroesophageal reflux were performed by Pearson correlation analyses. Results: All Patients had poor sleep quality, severe daytime sleepiness, moderate-severe sleep apnea, significant weak acid reflux and moderate coughing events at the baseline. Compared with the baseline, PSQI and ESS score were improved in treatment group after 1 week’s treatment, the improvement became stronger with duration of therapy (P＜0.05). GERD-Q score, VAS score, daytime and night cough symptom score were all significantly improved in these two groups after treatment (P＜0.05), while this improvement was more pronounced in the treatment group ( P＜0.05). There were significant correlation between AHI and VAS score (r=0.612, P＜0.05), weak acid reflux and VAS score (r=0.429, P＜0.05), weak acid reflux and AHI (r=0.366, P＜0.05). Conclusion: The improvement in chronic cough and gastroesophageal reflux was due to the resolution of obstructive sleep apnea. AHI and weak acid reflux may be critical factors affecting the therapeutic effect of chronic cough in obstructive sleep apnea concomitant gastroesophageal reflux patients.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effect of Continuous Positive Airway Pressure on Chronic Cough in Obstructive Sleep Apnea Concomitant Gastroesophageal Reflux Patients: A Retrospective Observational Study

Meng

et al. 2021

Preprint

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“…Different studies [ 50 – 52 ] have shown an improvement in snoring, gastro-esophageal reflux and oxygen saturation with CPAP treatment. In our case, they were found among the characteristics with the highest stability scores for the best pipelines of month-0 and month-1.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of predictive methods for early assessment of compliance with continuous positive airway pressure therapy

Rafael-Palou

Turino

Steblin

et al. 2018

BMC Med Inform Decis Mak

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BackgroundPatients suffering obstructive sleep apnea are mainly treated with continuous positive airway pressure (CPAP). Although it is a highly effective treatment, compliance with this therapy is problematic to achieve with serious consequences for the patients’ health. Unfortunately, there is a clear lack of clinical analytical tools to support the early prediction of compliant patients.MethodsThis work intends to take a further step in this direction by building compliance classifiers with CPAP therapy at three different moments of the patient follow-up, before the therapy starts (baseline) and at months 1 and 3 after the baseline.ResultsResults of the clinical trial shows that month 3 was the time-point with the most accurate classifier reaching an f1-score of 87% and 84% in cross-validation and test. At month 1, performances were almost as high as in month 3 with 82% and 84% of f1-score. At baseline, where no information of patients’ CPAP use was given yet, the best classifier achieved 73% and 76% of f1-score in cross-validation and test set respectively. Subsequent analyzes carried out with the best classifiers of each time point revealed baseline factors (i.e. headaches, psychological symptoms, arterial hypertension and EuroQol visual analog scale) closely related to the prediction of compliance independently of the time-point. In addition, among the variables taken only during the follow-up of the patients, Epworth and the average nighttime hours were the most important to predict compliance with CPAP.ConclusionsBest classifiers reported high performances after one month of treatment, being the third month when significant differences were achieved with respect to the baseline. Four baseline variables were reported relevant for the prediction of compliance with CPAP at each time-point. Two characteristics more were also highlighted for the prediction of compliance at months 1 and 3.Trial registrationClinicalTrials.gov Identifier, NCT03116958. Retrospectively registered on 17 April 2017.Electronic supplementary materialThe online version of this article (10.1186/s12911-018-0657-z) contains supplementary material, which is available to authorized users.

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“…However, in nonpregnant patients, adherence to CPAP therapy may actually decrease GERD symptoms. 107 Some patients on CPAP therapy do experience aerophagia, introduction of air into the esophagus, which results in gastrointestinal discomfort and belching. Aerophagia may be related to decreased lower esophageal sphincter tone, which could be of concern in pregnant patients on CPAP.…”

Section: Peripartum Management Of Osamentioning

confidence: 99%

Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management

Dominguez¹,

Krystal

Habib³

2018

Anesthesia &Amp; Analgesia

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Among obese pregnant women, 15%-20% have obstructive sleep apnea (OSA) and this prevalence increases along with body mass index and in the presence of other comorbidities. Prepregnancy obesity and pregnancy-related weight gain are certainly risk factors for sleep-disordered breathing in pregnancy, but certain physiologic changes of pregnancy may also increase a woman's risk of developing or worsening OSA. While it has been shown that untreated OSA in postmenopausal women is associated with a range of cardiovascular, pulmonary, and metabolic comorbidities, a body of literature is emerging that suggests OSA may also have serious implications for the health of mothers and fetuses during and after pregnancy. In this review, we discuss the following: pregnancy as a vulnerable period for the development or worsening of OSA; the associations between OSA and maternal and fetal outcomes; the current screening modalities for OSA in pregnancy; and current recommendations regarding peripartum management of OSA.

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Effect of CPAP Therapy on Symptoms of Nocturnal Gastroesophageal Reflux among Patients with Obstructive Sleep Apnea

Cited by 25 publications

References 20 publications

Effect of Continuous Positive Airway Pressure on Chronic Cough in Obstructive Sleep Apnea Concomitant Gastroesophageal Reflux Patients: A Retrospective Observational Study

Effect of Continuous Positive Airway Pressure on Chronic Cough in Obstructive Sleep Apnea Concomitant Gastroesophageal Reflux Patients: A Retrospective Observational Study

Comparative analysis of predictive methods for early assessment of compliance with continuous positive airway pressure therapy

Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management

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