Effect of Crataeva nurvala in experimental urolithiasis

Varalakshmi, P.; Yusuff, Shamila; Latha, E.

doi:10.1016/0378-8741(90)90082-5

Cited by 39 publications

(22 citation statements)

References 15 publications

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“…Many studies[57–929] have failed to detect significant changes in the serum Ca and PO 4 levels with KC therapy, which appears to be in concordance with the mechanism of action of KC. [6711] Various human studies[171930] evaluating the use of PT for nephrolithiasis and many experimental studies[11–16] investigating the possible mechanism of action of PT with lupeol extract of Crataeva nurvala failed to detect any significant effect on the serum levels and intrinsic metabolism of Ca and PO 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Studies on KC[935] failed to detect significant changes in the 24-hour urinary Ca and PO 4 ; however, in a review by Mattle and Hess,[35] the authors concluded that urinary Ca decreased by 8 to 40% in 9 studies, whereas it increased by 15.4% in one study. Experimental studies with PT have shown decreased CaOx and CaPO 4 crystallization;[11–1636–40] however, PT studies in human beings have not shown any significant changes in the urinary Ca and PO 4 levels. [17–193233]…”

Section: Discussionmentioning

confidence: 99%

“…[3–5] The benefit of potassium citrate (KC) in the dissolution of some renal stones is proven,[6–9] though with certain limitations. [610] Scientists have also explored the use of alternative herbal medicines (PT) for nephrolithiasis,[511–13] with both experimental studies[11–16] and some human trials[17–19] showing good results. Plant extracts with renal antilithogenic efficacy include lupeol[12–17] ( Crataeva nurvala ), aspartic acid-saponins ( Tribulus terrestris ) and sterols-alkaloids ( Boerhaavia diffusa and Dolichos biflorus ).…”

Section: Introductionmentioning

confidence: 99%

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Prospective randomized clinical trial comparing phytotherapy with potassium citrate in management of minimal burden (≤8 mm) nephrolithiasis

Bishnoi¹,

Agarwal²,

Bhatt³

2011

Urol Ann

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Aim:To compare efficacy and tolerability of phytotherapy (PT) vs. potassium citrate (KC) in patients with minimal nephrolithiasis. To compare and assess changes in value of certain serum (Ca2+, PO43-, uric acid [UA]) and urinary (24-hr Ca2+, PO43-, UA, citrate, oxalate, and urine pH) parameters in patients being treated with PT or KC.Materials and Methods:After clearance by the local institutional ethics committee, 60 patients of nephrolithiasis who had consented for the study, were enrolled (as per entry criteria) and randomized into citrate therapy (group-I) or PT (group-II). PT was administered as a nutritional supplement, using a lupeol-based extract (Tablet Calcury™, two tablets twice a day). They were monitored for the changes in the serum and urinary biochemical, radiological, and clinical parameters (efficacy and tolerability) as per protocol.Results:Group-I patients demonstrated favorable changes in certain biochemical parameters (decreased serum calcium, urinary UA/oxalate, increased urinary citrate and pH) along with significant symptomatic improvement (decrease in visual analogue pain score with increased stone clearance/reduction in stone size). Four (13.3%) patients of group-I had mild upper gastrointestinal discomfort which was controlled with antacids. Group-II patients had favorable changes in biochemical parameters (decreased serum UA and increased urinary citrate) along with significant symptomatic improvement (reduction/clearance in the stone size), but without any noticeable side effects.Conclusions:Medical therapies with both KC and PT (with lupeol extract using Calcury™) were effective in reducing the stone size and symptoms of nephrolithiasis. It appeared that KC was biochemically efficacious in producing some favorable biochemical changes with some side effects, whereas PT was probably clinically efficacious in hastening stone expulsion (<8 mm) without any observed adverse events. Although both the medical therapies were not effective in all aspects, we believe that PT using lupeol-based extract (Calcury™) may be used as an alternative form of medical therapy in select patients with minimal nephrolithiasis. Long-term randomized placebo-controlled trials are needed to better define the precise role of lupeol-based PT vs. citrate therapy in minimal nephrolithiasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prospective randomized clinical trial comparing phytotherapy with potassium citrate in management of minimal burden (≤8 mm) nephrolithiasis

Bishnoi¹,

Agarwal²,

Bhatt³

2011

Urol Ann

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“…[23] Urinary supersaturation is also considered to be one of the causative factors in calculogenesis. Similarly, phosphate excretion was also increased in stone forming animals that favor the nucleation and precipitation of calcium oxalate.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Hemalatha

2017

IJGP

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Objective: Aganosma dichotoma K. Schum has been traditionally used in the treatment of urological disorder in Ayurvedic system of medicine and also used by tribals of Chittoor district of Andhra Pradesh. Therefore, this study aims to establish its traditional claims and investigate the effect of root extract and fractions of A. dichotoma (Apocynaceae) against ethylene glycol (EG) induced urolithiasis in male albino rats. Materials and Methods: Lithiasis was induced by oral administration of ethylene glycolated water (0.75% v/v) in rats for 28 days and was manifested by the high level of calcium, oxalate, phosphate, creatinine, uric acid, and blood urea nitrogen (BUN) in both urine and serum. Polarized microscopy of urine, as well as histological study of kidney, was also performed in rats. Alcoholic extract, petroleum ether, chloroform, and butanol fractions were evaluated in this study. Result: Supplementation with ethanolic root extract of A. dichotoma (EAD) and their fractions significantly (P ˂ 0.001) reduced the elevated urinary oxalate, calcium, and phosphate level as well as also decreased the level of creatinine, uric acid, and BUN in serum. In urine microscopy and histology of the kidney samples, EAD and petroleum ether fraction (PF) showed maximum inhibition of crystal deposition in a dose-dependent manner as compared to control group. Discussion and Conclusion: The result of this study revealed that EAD and PF are endowed with antiurolithic activity and justifying folk information of the plant. Further investigations are required to illuminate the chemical constituents and mechanism liable for antiurolithic activity.

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“…Pharmacological activities: Analgesic, anti-inflammatory, antioxidant, demulcent, diuretic, lithotriptic [8] , litholytic [66] . Antiurolithiatic spectrum (reported): Bark against whewellite [67] Caryophyllaceae (11) Arenaria serpyllifolia L.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%