Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study

Umigai, Naofumi; Takeda, Ryuji; Mori, Atsuko

doi:10.1016/j.ctim.2018.09.003

Cited by 37 publications

(59 citation statements)

References 30 publications

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“…CRO is an aglycone of crocin found in the fruit of gardenia and the stigma of saffron, 37 which in its free-acid form is insoluble in water and most organic solvents. 38 CRO has been reported to have antioxidant and anti-inflammatory actions.…”

Section: Discussionmentioning

confidence: 99%

<p>Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats</p>

Liu

Liang

Zheng

et al. 2020

DDDT

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Arsenic trioxide (ATO) has been shown to induce hepatic injury. Crocetin is a primary constituent of saffron, which has been verified to have antioxidant and antiinflammatory effects. In the current experiment, we evaluated the efficacy of crocetin against ATO-induced hepatic injury and explored the potential molecular mechanisms in rats. Methods: Rats were pretreated with 25 or 50 mg/kg crocetin 6 h prior to treating with 5 mg/ kg ATO to induce hepatic injury daily for 7 days. Results: Treatment with crocetin attenuated ATO-induced body weight loss, decreases in food and water consumption, and improved ATO-induced hepatic pathological damage. Crocetin significantly inhibited ATO-induced alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) increases. Crocetin prevented ATO-induced liver malondialdehyde (MDA) and reactive oxygen species (ROS) levels. Crocetin abrogated the ATO-induced decrease of catalase (CAT) and superoxide dismutase (SOD) activity. Crocetin was found to significantly restore the protein levels of interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor-alpha (TNF-α). Furthermore, crocetin promoted the expression of nuclear factor erythroid 2 related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NADP(H): quinone oxidoreductase 1 (NQO1). Conclusion: These findings suggest that crocetin ameliorates ATO-induced hepatic injury in rats. In addition, the effect of crocetin might be related to its role in antioxidant stress, as an anti-inflammatory agent, and in regulating the Nrf2 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

<p>Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats</p>

Liu

Liang

Zheng

et al. 2020

DDDT

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“…On the other hand, participants reported feeling refreshed, and had less sleepiness upon waking, following crocetin administration, compared with placebo administration, with no differences in waking found in the PSG recordings [42]. However, taking crocetin was associated with a higher delta power (which is negatively linked with wake episodes during REM latency) [42].…”

Section: Crocetinmentioning

confidence: 99%

“…The methods employed to measure sleep outcomes varied across studies. Seven studies used subjective measures (i.e., diaries/logbooks and sleep questionnaires) [31][32][33][34][35][36][37], while one study used PSG/EEG [38,39], and five studies used a combination of PSG/EEG or actigraphy, and subjective measures [39][40][41][42][43].…”

Section: Dietary Supplementsmentioning

confidence: 99%

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Effects of Diet on Sleep: A Narrative Review

et al. 2020

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Many processes are involved in sleep regulation, including the ingestion of nutrients, suggesting a link between diet and sleep. Aside from studies investigating the effects of tryptophan, previous research on sleep and diet has primarily focused on the effects of sleep deprivation or sleep restriction on diet. Furthermore, previous reviews have included subjects with clinically diagnosed sleep-related disorders. The current narrative review aimed to clarify findings on sleep-promoting foods and outline the effects of diet on sleep in otherwise healthy adults. A search was undertaken in August 2019 from the Cochrane, MEDLINE (PubMed), and CINAHL databases using the population, intervention, control, outcome (PICO) method. Eligible studies were classified based on emerging themes and reviewed using narrative synthesis. Four themes emerged: tryptophan consumption and tryptophan depletion, dietary supplements, food items, and macronutrients. High carbohydrate diets, and foods containing tryptophan, melatonin, and phytonutrients (e.g., cherries), were linked to improved sleep outcomes. The authors posit that these effects may be due in part to dietary influences on serotonin and melatonin activity.

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“…However, human clinical trial studies have been conducted on the effects of the saffron extract on other diseases such as allergic asthma (Zilaee et al, 2019), resolution of inflammation in the metabolic syndrome (Kermani et al, 2017;Boskabady et al, 2020), mild/ moderate age-related macular degeneration (Broadhead et al, 2019), diabetic maculopathy (Sepahi et al, 2018), improving sleep quality (Umigai et al, 2018), and depression (Jam et al, 2017;Kashani et al, 2018;Lopresti et al, 2018;Moazen-Zadeh et al, 2018).…”

Section: Research Research Type Treatment Route Of Administrationmentioning

confidence: 99%

Toxicity of Saffron Extracts on Cancer and Normal Cells: A Review Article

Shakeri

Tayer

Shakeri

et al. 2020

Asian Pac J Cancer Prev

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Background and Aim: Medicinal plants have played an important role in human health since the Stone Age. According to WHO, 80% of Asian and African people rely on traditional medicine and medicinal plants to conserve their health. Saffron has received much attention among the herbal compounds related to cancer treatment. Methods: This review aims to provide an overview of in-vitro and in-vivo evaluation molecule mechanism for anti-tumor activity, cancer preventing and protective effects of saffron extract. The review is based on the available data accessible in PubMed, Science Direct, Google Scholar, Magiran.ir, and SID.ir databases. Results: Saffron has selective toxic and preventive effects on cancerous cells and without adverse effects on normal cells and prevents tumor formation. Saffron appears to reduce the toxic effects of anticancer drugs. Saffron has toxicity effects when used in high amounts, which are far greater than those are used in human food culture. Conclusions: Considering the observed effects of saffron on the removal of cancer cells, saffron extract can be used in the treatment and prevention of cancer after confirmation in human clinical trials. According to the high IC 50 of saffron extracts in normal cells, its toxicity against non-cancerous cells is low and its use is safe. Besides, the studies suggested the cytotoxic effects of saffron on some of the more cancers, including nervous system cancer and common cancers. Further studies are required to determine the effective dose and influence of mechanism of saffron in various animal type of cancers.

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Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study

Cited by 37 publications

References 30 publications

<p>Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats</p>

<p>Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats</p>

Effects of Diet on Sleep: A Narrative Review

Toxicity of Saffron Extracts on Cancer and Normal Cells: A Review Article

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