Effect of cromakalim on the purinergic and cholinergic transmission in the rat detrusor muscle

Boselli, Cinzia; Bianchi, Linda; Grana, E

doi:10.1016/s0014-2999(97)01148-5

Cited by 18 publications

(20 citation statements)

References 25 publications

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“…In order to compare our resulting ELAIS near‐ to mid‐IR colours to a local sample of galaxies observed with ISO , and to discuss how well the galaxy types can be separated with near‐ and mid‐IR colours, we made use of the data sets of Boselli et al (1998), Dale et al (2000) and Roussel et al (2001a). Naturally, there exists a large body of work performed with IRAS galaxies establishing near‐ and mid‐IR data bases (e.g.…”

Section: Colour–colour Distributionsmentioning

confidence: 99%

“…Boselli et al (1998) give their own near‐IR photometry. We performed a cross‐check of their K ‐band photometry between 2MASS values and found a fairly good consistency: apart from some Sc‐type galaxies, 2MASS isophotal magnitudes were 0.15 mag fainter than the Boselli values, with a scatter of 0.31 mag.…”

Section: Colour–colour Distributionsmentioning

confidence: 99%

“…There is a systematic difference by approximately a factor of 1.4 in fluxes of some galaxies common to the Roussel et al and Dale et al catalogues (see Roussel et al 2001a); however, none of these are included in our subsamples. The mid‐IR fluxes in Boselli et al (1998) are not published apart from SED plots; the values were provided by A. Boselli.…”

Section: Colour–colour Distributionsmentioning

confidence: 99%

“…The ELAIS project (Rowan‐Robinson et al 1999; Oliver et al 2000) stands as a bridge between the very deep galaxy surveys in the IR, mentioned above, and nearby galaxy surveys (e.g. Boselli et al 1998; Dale et al 2000; Roussel et al 2001a). ELAIS was the largest open time ISO project, with the driving ambitious goal to study the unobscured star formation out to redshifts of z ∼ 1.…”

Section: Introductionmentioning

confidence: 99%

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Near- and mid-infrared colours of star-forming galaxies in European Large Area ISO Survey fields

Vaïsänen

Morel

Rowan‐Robinson

et al. 2002

Monthly Notices of the Royal Astronomical Society

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We present J and K-band near-infrared photometry of a sample of mid-infrared sources detected by the Infrared Space Observatory (ISO) as part of the European Large Area ISO-Survey (ELAIS) and study their classification and star-forming properties. We have used the Preliminary ELAIS Catalogue for the 6.7 µm (LW2) and 15 µm (LW3) fluxes. All of the high-reliability LW2 sources and 80 per cent of the LW3 sources are identified in the near-IR survey reaching K ≈ 17.5 mag. The nearto mid-IR flux ratios can effectively be used to separate stars from galaxies in mid-IR surveys. The stars detected in our survey region are used to derive a new accurate calibration for the ELAIS ISOCAM data in both the LW2 and LW3 filters. We show that near to mid-IR colour-colour diagrams can be used to further classify galaxies, as well as study star-formation. The ISOCAM ELAIS survey is found to mostly detect strongly star-forming late-type galaxies, possibly starburst powered galaxies, and it also picks out obscured AGN. The ELAIS galaxies yield an average mid-IR flux ratio LW2/LW3 = 0.67 ± 0.27. We discuss the f ν (6.7µm)/f ν (15µm) ratio as a star formation tracer using ISO and IRAS data of a local comparison sample. We find that the f ν (2.2µm)/f ν (15µm) ratio is also a good indicator of activity level in galaxies and conclude that the drop in the f ν (6.7µm)/f ν (15µm) ratio seen in strongly star-forming galaxies is a result of both an increase of 15µm emission and an apparent depletion of 6.7µm emission. Near-IR data together with the mid-IR give the possibility to estimate the relative amount of interstellar matter in the galaxies.

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Section: Colour–colour Distributionsmentioning

confidence: 99%

Section: Colour–colour Distributionsmentioning

confidence: 99%

Section: Colour–colour Distributionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Near- and mid-infrared colours of star-forming galaxies in European Large Area ISO Survey fields

Vaïsänen

Morel

Rowan‐Robinson

et al. 2002

Monthly Notices of the Royal Astronomical Society

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“…ZM 226600 and pinacidil instilled into the bladder (10 )7 M) or following systemic administration almost completely abolished bladder overactivity and improved residual volume and frequency of micturition. Boselli et al [31] showed an inhibition of the electrically evoked response of rat detrusor muscle by cromakalim. The effect of the PCO YM934 was investigated in isolated pig detrusor muscle [12].…”

Section: Discussionmentioning

confidence: 98%

Inhibitory effects of different ATP‐sensitive potassium channel openers on electrically generated and carbachol‐induced contractions of porcine and human detrusor muscle

Badawi

Ding

Bross

2008

Fundamemntal Clinical Pharma

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The inhibitory effects of different potassium channel openers (PCOs) on electrically generated and carbachol-induced contractions of porcine and human detrusor muscle were examined. PCOs could be an interesting substance class for treatment of detrusor overactivity. Experiments were performed on muscle strips suspended in a tissue bath. Human tissue originated from patients who underwent total cystectomy. The concentration-relaxation curves of the first-generation PCOs cromakalim and pinacidil and the untypical PCO minoxidil were performed using carbachol-precontracted detrusor muscle strips of pigs and humans. Additionally, the inhibitory effects of cromakalim, pinacidil and minoxidil on electrically generated contractions of porcine detrusor muscle were examined. Furthermore, the inhibitory effect of the second-generation, bladder-selective PCO ZM 226600 on electrically generated contractions of the human detrusor muscle was determined. Frequency-response curves were performed before and after incubation with one PCO used in two different concentrations. In humans, cromakalim and pinacidil led to a maximum decrease of 73.5 and 68.4% and showed mean pD2 values of 6.65 and 5.5, respectively. In pigs, cromakalim and pinacidil led to a maximum decrease of 90.6 and 93.6% and showed mean pD2 values of 6.39 and 5.01, respectively. Minoxidil did not significantly decrease the precontraction at the highest used concentration in both species. Cromakalim exhibited the biggest inhibitory effect being significant at 10(-5) and 10(-6) M. Pinacidil showed only a significant inhibitory effect at 10(-5) M which was smaller than that of cromakalim. At 3 x 10(-6) M only a very small effect occurred at 1 Hz. Minoxidil did not inhibit the contractions at both examined concentrations except for a very small effect at 1 Hz. In humans, ZM 226600 exhibited at 10(-6) and 10(-5) M a significant inhibitory effect. At 10(-7) M it was only significant at one frequency.

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Comparative study of the contractile activity evoked by ATP and diadenosine tetraphosphate in isolated rat urinary bladder

Khattab¹,

Al‐Shabanah²,

El‐Kashef³

2002

Pharmacological Research

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Effect of cromakalim on the purinergic and cholinergic transmission in the rat detrusor muscle

Cited by 18 publications

References 25 publications

Near- and mid-infrared colours of star-forming galaxies in European Large Area ISO Survey fields

Near- and mid-infrared colours of star-forming galaxies in European Large Area ISO Survey fields

Inhibitory effects of different ATP‐sensitive potassium channel openers on electrically generated and carbachol‐induced contractions of porcine and human detrusor muscle

Comparative study of the contractile activity evoked by ATP and diadenosine tetraphosphate in isolated rat urinary bladder

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