Effect of crosslinker structure and crosslinker/monomer ratio on network parameters and thermodynamic properties of Poly (N-isopropylacrylamide) hydrogels

Gökçeören, Argun Talat; Şenkal, Bahire Filiz; Erbi̇l, Candan

doi:10.1007/s10965-014-0370-2

Cited by 13 publications

(8 citation statements)

References 45 publications

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“…A decreased SR was expected with increased crosslink density due to greater restriction of NIPAAM polymer chain mobility . The hydrophilicity of PEGDA may result in a reduction of the NIPAAM hydrophobic interactions, which could also contribute to the reduction of SR with PEGDA incorporation . However, greater SR was observed for the more densely crosslinked hydrogel (e.g., 12 µL PEGDA; Figure B).…”

Section: Resultsmentioning

confidence: 96%

“…[63] The hydrophilicity of PEGDA may result in a reduction of the NIPAAM hydrophobic interactions, which could also contribute to the reduction of SR with PEGDA incorporation. [64][65][66] However, greater SR was observed for the more densely crosslinked hydrogel (e.g., 12 µL PEGDA; Figure 1B). The SR of the beva-8 µL PEGDA gel was significantly different to the unloaded gel (p < 0.05) at 25 °C; but not significantly different (p > 0.05) at 37 and 48 °C.…”

Section: Loading and Characterization Of Bevacizumab-nipaam Hydrogelmentioning

confidence: 99%

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Comparative Study of In Situ Loaded Antibody and PEG‐Fab NIPAAM Gels

Awwad

Al-Shohani

Khaw

et al. 2017

Macromolecular Bioscience

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Hydrogels can potentially prolong the release of a therapeutic protein, especially to treat blinding conditions. One challenge is to ensure that the protein and hydrogel are intimately mixed by better protein entanglement within the hydrogel. N-isopropylacrylamide (NIPAAM) gels are optimized with poly(ethylene glycol) diacrylate (PEDGA) crosslinker in the presence of either bevacizumab or PEG conjugated ranibizumab (PEG -Fab ). The release profiles of the hydrogels are evaluated using an outflow model of the eye, which is previously validated for human clearance of proteins. Release kinetics of in situ loaded bevacizumab-NIPAAM gels displays a prolonged bimodal release profile in phosphate buffered saline compared to bevacizumab loaded into a preformed NIPAAM gel. Bevacizumab release in simulated vitreous from in situ loaded gels is similar to bevacizumab control indicating that diffusion through the vitreous rather than from the gel is rate limiting. Ranibizumab is site-specifically PEGylated by disulfide rebridging conjugation. Prolonged and continuous release is observed with the in situ loaded PEG -Fab -NIPAAM gels compared to PEG -Fab injection (control). Compared to an unmodified protein, there is better mixing due to PEG entanglement and compatibility of PEG -Fab within the NIPAAM-PEDGA hydrogel. These encouraging results suggest that the extended release of PEGylated proteins in the vitreous can be achieved using injectable hydrogels.

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Section: Resultsmentioning

confidence: 96%

Section: Loading and Characterization Of Bevacizumab-nipaam Hydrogelmentioning

confidence: 99%

Comparative Study of In Situ Loaded Antibody and PEG‐Fab NIPAAM Gels

Awwad

Al-Shohani

Khaw

et al. 2017

Macromolecular Bioscience

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“…A further increase in monomer concentration, however, results in decreased water absorbency. This may be due to preferential homopolymerization over graft copolymerization, an increase in the viscosity of the medium, which hinders the movement of free radicals and monomer molecules, the enhanced chance of chain transfer to monomer molecules, andnon-hydrolyzed amide groups of grafted and ungrafted MAAm chains [10] [23]. MBAAm] concentration in the networks.…”

Section: Effect Of Monomer Concentration On Swelling With Timementioning

confidence: 99%

Synthesis and Characterization of Crosslinked Hydrogel of Konkoli (<i>Maesopsis eminii</i>) Grafted Polymethylacrylamide for a Preliminary Study as an Insulin Delivery System

Ugwu¹,

Barminas²,

Nkafamiya³

et al. 2016

JBM

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Polysaccharide has lately received a significant attention in the formulation of drug delivery system based on the abundant availability, non-toxicity and the various ways its nature, structure and functionality can be modified. In this preliminary work on Konkoli (Maesopsis eminii) galactomannan (KG), it was modified by grafting with methacrylamide (MAAm) using ammonium persulphate (ASP) as initiator. The grafted galactomannan was then crosslinked using N, N-methylenebisacrylamide (N, N-MBAAm) to produce the hydrogel called konkoli grafted polymethylacrylamide (KG-g-poly (MAAm)). FTIR analyses confirm crosslinking and other changes in the functionality of KG-g-poly (MAAm) compared to KG. Swelling properties which are fundamental to the potential properties of any hydrogel as a drug delivery system were studied for KG-g-poly (MAAm) with varied amount of monomer (MAAm), crosslinker and pH with respect to time and temperature. There was a rapid rise followed by a dramatic fall in the swelling capacity with increase in both monomer and crosslinker concentration. The swelling capacity of KG-g-poly (MAAm) also improves as the pH of the medium was changed from acidic to alkaline. Generally, the swelling capacity of KG-g-poly (MAAm) increases with time and temperature of immersion. This result therefore encourages further studies as it presents KG-g-poly (MAAm) potentials in such application as insulin delivery system.

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“…Our experiments aimed to use N-isopropylacrylamide (NIPAM) as a matrix to prepare a temperature sensitive intelligent hydrogel. During gel preparation, polymerization parameters such as polymerization temperature, the ratio of crosslinker to monomer, and the type of polymer composition could contribute to the desirable properties of thermo-sensitive hydrogels [24]. Even though the polymers of NIPAM, CMC, and acrylic acid (AA) in Na-montmorillonite (MMT) have been fabricated [25], the principal element of preparation of thermo-sensitive hydrogel and the influence mechanism are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Optimization of the Thermo-Sensitive Hydrogel Carboxymethyl Cellulose/Poly(N-isopropylacrylamide-co-acrylic acid) for U(VI) Removal from Aqueous Solution

et al. 2020

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In this work, the thermo-sensitive materials N-isopropylacrylamide (NIPAM) and acrylic acid (AA) were crosslinked with carboxymethyl cellulose (CMC) (CMC/P (NIPAM-co-AA)) via a free radical polymerization method for the removal of U(VI) from aqueous solution. The L16 (45) orthogonal experiments were designed for the optimization of the synthesis condition. The chemical structures of the crosslinking hydrogel were confirmed by FTIR spectroscopy. The microstructural analyses were conducted though scanning electron microscopy (SEM) to show the pore structure of the hydrogel. The adsorption performance of the CMC/P (NIPAM-co-AA) hydrogel for the uptake of U(VI) from simulated wastewater was also investigated. The adsorption reached equilibrium within 1 h. Under the reaction of pH = 6 and a temperature of 298 K, an initial concentration of U(VI) of 5 mg·L−1, and 10 mg of the CMC/P(NIPAM-co-AA) hydrogel, the maximum adsorption capacity was 14.69 mg g−1. The kinetics fitted perfectly with the pseudo-second-order model, and the isotherms for the composite hydrogel adsorption of U(VI) was in accordance with the Langmuir model. The chemical modification confirmed that the acylamino group played an important role in uranium adsorption. The desorption and reusability study revealed that the resolution rate was still available at approximately 77.74% after five alternate heating cycles at 20 and 50 °C of adsorption-desorption.

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Effect of crosslinker structure and crosslinker/monomer ratio on network parameters and thermodynamic properties of Poly (N-isopropylacrylamide) hydrogels

Cited by 13 publications

References 45 publications

Comparative Study of In Situ Loaded Antibody and PEG‐Fab NIPAAM Gels

Comparative Study of In Situ Loaded Antibody and PEG‐Fab NIPAAM Gels

Synthesis and Characterization of Crosslinked Hydrogel of Konkoli (<i>Maesopsis eminii</i>) Grafted Polymethylacrylamide for a Preliminary Study as an Insulin Delivery System

Fabrication and Optimization of the Thermo-Sensitive Hydrogel Carboxymethyl Cellulose/Poly(N-isopropylacrylamide-co-acrylic acid) for U(VI) Removal from Aqueous Solution

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Effect of crosslinker structure and crosslinker/monomer ratio on network parameters and thermodynamic properties of Poly (N-isopropylacrylamide) hydrogels

Cited by 13 publications

References 45 publications

Comparative Study of In Situ Loaded Antibody and PEG‐Fab NIPAAM Gels

Comparative Study of In Situ Loaded Antibody and PEG‐Fab NIPAAM Gels

Synthesis and Characterization of Crosslinked Hydrogel of Konkoli (&lt;i&gt;Maesopsis eminii&lt;/i&gt;) Grafted Polymethylacrylamide for a Preliminary Study as an Insulin Delivery System

Fabrication and Optimization of the Thermo-Sensitive Hydrogel Carboxymethyl Cellulose/Poly(N-isopropylacrylamide-co-acrylic acid) for U(VI) Removal from Aqueous Solution

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Synthesis and Characterization of Crosslinked Hydrogel of Konkoli (<i>Maesopsis eminii</i>) Grafted Polymethylacrylamide for a Preliminary Study as an Insulin Delivery System