DEDICATIONThis dissertation is dedicated to my parents, Charles and Karen Guzelian, and my sister, Krista Guzelian, whose sacrifices for my education, personal development, and wellbeing have positively shaped my growth as a critical thinker and successful young adult.Their unconditional love and constant support for these endeavors cannot be expressed fully in words.iv ACKNOLWEDGEMNTS I would like to thank my thesis advisor, Dr. Amirali Zandinejad, for his patience, guidance, trust, and encouragement throughout the entire research process. Dr. Zandinejad offers a wealth of knowledge on prosthodontics, clinical dental training, and evidencebased dentistry, and he maintained very high standards in this thesis to produce an exceptional final product. Dr. Zandinejad provided confidence in my abilities that I will succeed in dental school and beyond.In addition, I would like to thank my thesis committee members: Dr. Tamer AbdelAzim, for his step-wise clarity during the impressions process and expertise on CAD/CAM applications in dentistry; Dr. Michael Metz, for his high expectations in my degree to yield significant and publishable results; and Dr. Don Demuth, for his willingness to listen and participate in a field outside his own expertise as another prominent, national voice within oral biology.I would like to thank Dr. Dean Morton for approving a non-specialty graduate student to complete a thesis-based degree within his department, a consideration which included specialty equipment, clinical materials, financial support, and faculty involvement to complete the study.I would like to thank Dr. Claudio Maldonado for allowing me access to his laboratory for imaging, which included a stereomicroscope and capturing software. This in vitro study compared marginal gap size in anterior lithium disilicate veneers produced by conventional and digital impressions. One typodont right central incisor was prepared for an all-ceramic cast. Ten conventional veneers were fabricated using Type IV stone, PVS, and IPS e.max press, while ten digital veneers were fabricated using Lava COS (3M ESPE) and IPS e.max CAD/CAM processing and milling. Samples were divided double-blindly, captured at 45X magnification, evaluated at three images per orientation (B-D-M-P), and measured at three distances (largest, smallest, best fit) per image. Data points were entered into SPSS code for one-way and two-way ANOVA, t-testing, Chi square, and odds ratio. Compared to conventional technique, digital veneers recorded greater mean gap distances at all orientations, fewer "good fit" locations, and average gap size ≥ 120 µm. All analysis techniques were statistically significant. In vivo follow-up is necessary to justify digital impressions in clinical settings.vii